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Article

Characterization of KIF20B as a novel prognostic biomarker and therapeutic target for breast cancer

  • Authors:
    • Regina Wachuka Mbugua
    • Atsushi Takano
    • Bayarbat Tsevegjav
    • Tomoyuki Yokose
    • Toshinari Yamashita
    • Yohei Miyagi
    • Yataro Daigo
  • View Affiliations / Copyright

    Affiliations: Department of Medical Oncology and Cancer Center, Shiga University of Medical Science, Otsu, Shiga 520‑2192, Japan, Department of Pathology, Kanagawa Cancer Center, Yokohama, Kanagawa 241‑8515, Japan, Department of Breast and Endocrine Surgery, Kanagawa Cancer Center, Yokohama, Kanagawa 241‑8515, Japan, Molecular Pathology and Genetics Division, Kanagawa Cancer Center, Research Institute, Yokohama, Kanagawa 241‑8515, Japan
  • Article Number: 43
    |
    Published online on: February 29, 2024
       https://doi.org/10.3892/ijo.2024.5631
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Abstract

Despite advances in treatment and early detection, breast cancer remains one of the most common types of cancer and is the second leading cause of cancer death after lung cancer in women. Therefore, there is an urgent need to develop new biomarkers and therapeutic targets for the treatment of breast cancer. Based on gene expression profiles and subsequent screening performed in a preliminary study, kinesin family member 20B (KIF20B) was selected as a candidate target molecule, because it was highly and frequently expressed in all subtypes of breast cancer and barely detected in normal tissues. Reverse transcription‑quantitative PCR and western blotting revealed that KIF20B mRNA and protein expression levels were upregulated in most breast cancer cell lines but were scarcely expressed in normal mammary epithelial cells. Immunohistochemical staining of a tissue microarray showed that KIF20B was detected in 145 out of 251 (57.8%) breast cancer tissues. Strong KIF20B expression was significantly related to advanced pathological N stage. Moreover, patients with breast cancer and strong KIF20B expression exhibited a significantly worse prognosis than those with weak or negative KIF20B expression (P<0.0001, log‑rank test). In multivariate analysis, strong expression was an independent prognostic factor for patients with breast cancer. Furthermore, knockdown of KIF20B expression by small interfering RNA inhibited breast cancer cell proliferation and induced apoptosis. In addition, Matrigel cell invasion assays revealed that the invasiveness of breast cancer cells was significantly decreased by KIF20B silencing. Since KIF20B is an oncoprotein that is strongly expressed in highly malignant clinical breast cancer and serves a pivotal role in breast cancer cell proliferation, survival and invasion, KIF20B could be considered a candidate biomarker for prognostic prediction and a potential molecular target for developing new therapeutics, such as small molecule inhibitors, for a wide variety of breast cancers.
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1 

Giaquinto AN, Sung H, Miller KD, Kramer JL, Newman LA, Minihan A, Jemal A and Siegel RL: Breast cancer statistics, 2022. CA Cancer J Clin. 72:524–541. 2022. View Article : Google Scholar : PubMed/NCBI

2 

Arnold M, Morgan E, Rumgay H, Mafra A, Singh D, Laversanne M, Vignat J, Gralow JR, Cardoso F, Siesling S and Soerjomataram I: Current and future burden of breast cancer: Global statistics for 2020 and 2040. Breast. 66:15–23. 2022. View Article : Google Scholar : PubMed/NCBI

3 

Voduc KD, Cheang MCU, Tyldesley S, Gelmon K, Nielsen TO and Kennecke H: Breast cancer subtypes and the risk of local and regional relapse. J Clin Oncol. 28:1684–1691. 2010. View Article : Google Scholar : PubMed/NCBI

4 

Tong CWS, Wu M, Cho WCS and To KKW: Recent advances in the treatment of breast cancer. Front Oncol. 8:2272018. View Article : Google Scholar : PubMed/NCBI

5 

Jamdade VS, Sethi N, Mundhe NA, Kumar P, Lahkar M and Sinha N: Therapeutic targets of triple negative breast cancer: A review. Br J Pharmacol. 172:4228–4237. 2015. View Article : Google Scholar : PubMed/NCBI

6 

Raphael A, Salmon-Divon M, Epstein J, Zahavi T, Sonnenblick A and Shachar SS: Alpelisib efficacy in hormone receptor-positive HER2-negative PIK3CA-mutant advanced breast cancer post-everolimus treatment. Genes (Basel). 29:17632022. View Article : Google Scholar

7 

Hudis CA and Gianni L: Triple-negative breast cancer: An unmet medical need. Oncologist. 16 (Suppl 1):S1–S11. 2011. View Article : Google Scholar

8 

Robson M, Im SA, Senkus E, Xu B, Domchek SM, Masuda N, Delaloge S, Li W, Tung N, Armstrong A, et al: Olaparib for metastatic breast cancer in patients with a germline BRCA mutation. N Engl J Med. 377:523–533. 2017. View Article : Google Scholar : PubMed/NCBI

9 

Hou Y, Peng Y and Li Z: Update on prognostic and predictive biomarkers of breast cancer. Semin Diagn Pathol. 39:322–332. 2022. View Article : Google Scholar : PubMed/NCBI

10 

Chung C, Yeung VTY and Wong KCW: Prognostic and predictive biomarkers with therapeutic targets in breast cancer: A 2022 update on current developments, evidence, and recommendations. J Oncol Pharm Pract. 15:1343–1360. 2023. View Article : Google Scholar

11 

Ovcaricek T, Takac I and Matos E: Multigene expression signatures in early hormone receptor positive HER 2 negative breast cancer. Radiol Oncol. 53:285–292. 2019. View Article : Google Scholar : PubMed/NCBI

12 

Daigo Y and Nakamura Y: From cancer genomics to thoracic oncology: Discovery of new biomarkers and therapeutic targets for lung and esophageal carcinoma. Gen Thorac Cardiovasc Surg. 56:43–53. 2008. View Article : Google Scholar : PubMed/NCBI

13 

Daigo Y, Takano A, Teramoto K, Chung S and Nakamura Y: A systematic approach to the development of novel therapeutics for lung cancer using genomic analyses. Clin Pharmacol Ther. 94:218–223. 2013. View Article : Google Scholar : PubMed/NCBI

14 

Ishikawa N, Daigo Y, Takano A, Taniwaki M, Kato T, Hayama S, Murakami H, Takeshima Y, Inai K, Nishimura H, et al: Increases of amphiregulin and transforming growth factor-alpha in serum as predictors of poor response to gefitinib among patients with advanced non-small cell lung cancers. Cancer Res. 65:9176–9184. 2005. View Article : Google Scholar : PubMed/NCBI

15 

Ishikawa N, Daigo Y, Yasui W, Inai K, Nishimura H, Tsuchiya E, Kohno N and Nakamura Y: ADAM8 as a novel serological and histochemical marker for lung cancer. Clin Cancer Res. 10:8363–8370. 2004. View Article : Google Scholar : PubMed/NCBI

16 

Kakiuchi S, Daigo Y, Ishikawa N, Furukawa C, Tsunoda T, Yano S, Nakagawa K, Tsuruo T, Kohno N, Fukuoka M, et al: Prediction of sensitivity of advanced non-small cell lung cancers to gefitinib (Iressa, ZD1839). Hum Mol Genet. 13:3029–3043. 2004. View Article : Google Scholar : PubMed/NCBI

17 

Kato T, Daigo Y, Hayama S, Ishikawa N, Yamabuki T, Ito T, Miyamoto M, Kondo S and Nakamura Y: A novel human tRNA-dihydrouridine synthase involved in pulmonary carcinogenesis. Cancer Res. 65:5638–5646. 2005. View Article : Google Scholar : PubMed/NCBI

18 

Kikuchi T, Daigo Y, Katagiri T, Tsunoda T, Okada K, Kakiuchi S, Zembutsu H, Furukawa Y, Kawamura M, Kobayashi K, et al: Expression profiles of non-small cell lung cancers on cDNA microarrays: identification of genes for prediction of lymph-node metastasis and sensitivity to anticancer drugs. Oncogene. 22:2192–2205. 2003. View Article : Google Scholar : PubMed/NCBI

19 

Suzuki C, Daigo Y, Ishikawa N, Kato T, Hayama S, Ito T, Tsuchiya E and Nakamura Y: ANLN plays a critical role in human lung carcinogenesis through the activation of RHOA and by involvement in the phosphoinositide 3-kinase/AKT pathway. Cancer Res. 65:11314–11325. 2005. View Article : Google Scholar : PubMed/NCBI

20 

Kakiuchi S, Daigo Y, Tsunoda T, Yano S, Sone S and Nakamura Y: Genome-wide analysis of organ-preferential metastasis of human small cell lung cancer in mice. Mol Cancer Res. 1:485–499. 2003.PubMed/NCBI

21 

Taniwaki M, Daigo Y, Ishikawa N, Takano A, Tsunoda T, Yasui W, Inai K, Kohno N and Nakamura Y: Gene expression profiles of small-cell lung cancers: Molecular signatures of lung cancer. Int J Oncol. 29:567–575. 2006.PubMed/NCBI

22 

Oshita H, Nishino R, Takano A, Fujitomo T, Aragaki M, Kato T, Akiyama H, Tsuchiya E, Kohno N, Nakamura Y and Daigo Y: RASEF is a novel diagnostic biomarker and a therapeutic target for lung cancer. Mol Cancer Res. 11:937–951. 2013. View Article : Google Scholar : PubMed/NCBI

23 

Hayama S, Daigo Y, Yamabuki T, Hirata D, Kato T, Miyamoto M, Ito T, Tsuchiya E, Kondo S and Nakamura Y: Phosphorylation and activation of cell division cycle associated 8 by aurora kinase B plays a significant role in human lung carcinogenesis. Cancer Res. 67:4113–4122. 2007. View Article : Google Scholar : PubMed/NCBI

24 

Ishikawa N, Daigo Y, Takano A, Taniwaki M, Kato T, Tanaka S, Yasui W, Takeshima Y, Inai K, Nishimura H, et al: Characterization of SEZ6L2 cell-surface protein as a novel prognostic marker for lung cancer. Cancer Sci. 97:737–745. 2006. View Article : Google Scholar : PubMed/NCBI

25 

Kato T, Sato N, Hayama S, Yamabuki T, Ito T, Miyamoto M, Kondo S, Nakamura Y and Daigo Y: Activation of Holliday junction recognizing protein involved in the chromosomal stability and immortality of cancer cells. Cancer Res. 67:8544–8553. 2007. View Article : Google Scholar : PubMed/NCBI

26 

Takano A, Ishikawa N, Nishino R, Masuda K, Yasui W, Inai K, Nishimura H, Ito H, Nakayama H, Miyagi Y, et al: Identification of nectin-4 oncoprotein as a diagnostic and therapeutic target for lung cancer. Cancer Res. 69:6694–6703. 2009. View Article : Google Scholar : PubMed/NCBI

27 

Kobayashi Y, Takano A, Miyagi Y, Tsuchiya E, Sonoda H, Shimizu T, Okabe H, Tani T, Fujiyama Y and Daigo Y: Cell division cycle-associated protein 1 overexpression is essential for the malignant potential of colorectal cancers. Int J Oncol. 44:69–77. 2014. View Article : Google Scholar : PubMed/NCBI

28 

Thang PM, Takano A, Yoshitake Y, Shinohara M, Murakami Y and Daigo Y: Cell division cycle associated 1 as a novel prognostic biomarker and therapeutic target for oral cancer. Int J Oncol. 49:1385–1393. 2016. View Article : Google Scholar : PubMed/NCBI

29 

Daigo K, Takano A, Thang PM, Yoshitake Y, Shinohara M, Tohnai I, Murakami Y, Maegawa J and Daigo Y: Characterization of KIF11 as a novel prognostic biomarker and therapeutic target for oral cancer. Int J Oncol. 52:155–165. 2018.PubMed/NCBI

30 

Nakamura M, Takano A, Thang PM, Tsevegjav B, Zhu M, Yokose T, Yamashita T, Miyagi Y and Daigo Y: Characterization of KIF20A as a prognostic biomarker and therapeutic target for different subtypes of breast cancer. Int J Oncol. 57:277–288. 2020. View Article : Google Scholar : PubMed/NCBI

31 

Tsevegjav B, Takano A, Zhu M, Yoshitake Y, Shinohara M and Daigo Y: Holliday junction recognition protein as a prognostic biomarker and therapeutic target for oral cancer. Int J Oncol. 60:262022. View Article : Google Scholar : PubMed/NCBI

32 

Zhu M, Takano A, Tsevegjav B, Yoshitake Y, Shinohara M and Daigo Y: Characterization of Opa interacting protein 5 as a new biomarker and therapeutic target for oral cancer. Int J Oncol. 60:272022. View Article : Google Scholar : PubMed/NCBI

33 

Hirokawa N, Noda Y and Okada Y: Kinesin and dynein superfamily proteins in organelle transport and cell division. Curr Opin Cell Biol. 10:60–73. 1998. View Article : Google Scholar : PubMed/NCBI

34 

Kanehira M, Katagiri T, Shimo A, Takata R, Shuin T, Miki T, Fujioka T and Nakamura Y: Oncogenic role of MPHOSPH1, a cancer-testis antigen specific to human bladder cancer. Cancer Res. 67:3276–3285. 2007. View Article : Google Scholar : PubMed/NCBI

35 

Lin WF, Lin XL, Fu SW, Yang L, Tang CT, Gao YJ, Chen HY and Ge ZZ: Pseudopod-associated protein KIF20B promotes Gli1-induced epithelial-mesenchymal transition modulated by pseudopodial actin dynamic in human colorectal cancer. Mol Carcinog. 57:911–925. 2018. View Article : Google Scholar : PubMed/NCBI

36 

Liu X, Zhou Y, Liu X, Peng A, Gong H, Huang L, Ji K, Petersen RB, Zheng L and Huang K: MPHOSPH1: A potential therapeutic target for hepatocellular carcinoma. Cancer Res. 74:6623–6634. 2014. View Article : Google Scholar : PubMed/NCBI

37 

Chen J, Zhao CC, Chen FR, Feng GW, Luo F and Jiang T: KIF20B promotes cell proliferation and may be a potential therapeutic target in pancreatic cancer. J Oncol. 2021:55724022021.PubMed/NCBI

38 

Li ZY, Wang ZX and Li CC: Kinesin family member 20B regulates tongue cancer progression by promoting cell proliferation. Mol Med Rep. 19:2202–2210. 2019.PubMed/NCBI

39 

Sobin LH, Gospodarowicz MK and Wittekind C: TNM classification of malignant tumours. 7th edition. John Wiley & Sons; 2011

40 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(−Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

41 

Cao L and Niu Y: Triple negative breast cancer: Special histological types and emerging therapeutic methods. Cancer Biol Med. 17:293–306. 2020. View Article : Google Scholar : PubMed/NCBI

42 

Pearson GW: Control of invasion by epithelial-to-mesenchymal transition programs during metastasis. J Clin Med. 8:6462019. View Article : Google Scholar : PubMed/NCBI

43 

Matsumoto-Taniura N, Pirollet F, Monroe R, Gerace L and Westendorf JM: Identification of novel M phase phosphoproteins by expression cloning. Mol Biol Cell. 7:1455–1469. 1996. View Article : Google Scholar : PubMed/NCBI

44 

Abaza A, Soleilhac JM, Westendorf J, Piel M, Crevel I, Roux A and Pirollet F: M phase phosphoprotein 1 is a human plus-end-directed kinesin-related protein required for cytokinesis. J Biol Chem. 278:27844–27852. 2003. View Article : Google Scholar : PubMed/NCBI

45 

Kamimoto T, Zama T, Aoki R, Muro Y and Hagiwara M: Identification of a novel kinesin-related protein, KRMP1, as a target for mitotic peptidyl-prolyl isomerase Pin1. J Biol Chem. 276:37520–37528. 2001. View Article : Google Scholar : PubMed/NCBI

46 

Cheng CW and Tse E: PIN1 in cell cycle control and cancer. Front Pharmacol. 9:13672018. View Article : Google Scholar : PubMed/NCBI

47 

Liou YC, Zhou XZ and Lu KP: Prolyl isomerase Pin1 as a molecular switch to determine the fate of phosphoproteins. Trends Biochem Sci. 36:501–514. 2011. View Article : Google Scholar : PubMed/NCBI

48 

Wulf GM, Ryo A, Wulf GG, Lee SW, Niu T, Petkova V and Lu KP: Pin1 is overexpressed in breast cancer and cooperates with Ras signaling in increasing the transcriptional activity of c-Jun towards cyclin D1. EMBO J. 20:3459–3472. 2001. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Mbugua RW, Takano A, Tsevegjav B, Yokose T, Yamashita T, Miyagi Y and Daigo Y: Characterization of KIF20B as a novel prognostic biomarker and therapeutic target for breast cancer. Int J Oncol 64: 43, 2024.
APA
Mbugua, R.W., Takano, A., Tsevegjav, B., Yokose, T., Yamashita, T., Miyagi, Y., & Daigo, Y. (2024). Characterization of KIF20B as a novel prognostic biomarker and therapeutic target for breast cancer. International Journal of Oncology, 64, 43. https://doi.org/10.3892/ijo.2024.5631
MLA
Mbugua, R. W., Takano, A., Tsevegjav, B., Yokose, T., Yamashita, T., Miyagi, Y., Daigo, Y."Characterization of KIF20B as a novel prognostic biomarker and therapeutic target for breast cancer". International Journal of Oncology 64.4 (2024): 43.
Chicago
Mbugua, R. W., Takano, A., Tsevegjav, B., Yokose, T., Yamashita, T., Miyagi, Y., Daigo, Y."Characterization of KIF20B as a novel prognostic biomarker and therapeutic target for breast cancer". International Journal of Oncology 64, no. 4 (2024): 43. https://doi.org/10.3892/ijo.2024.5631
Copy and paste a formatted citation
x
Spandidos Publications style
Mbugua RW, Takano A, Tsevegjav B, Yokose T, Yamashita T, Miyagi Y and Daigo Y: Characterization of KIF20B as a novel prognostic biomarker and therapeutic target for breast cancer. Int J Oncol 64: 43, 2024.
APA
Mbugua, R.W., Takano, A., Tsevegjav, B., Yokose, T., Yamashita, T., Miyagi, Y., & Daigo, Y. (2024). Characterization of KIF20B as a novel prognostic biomarker and therapeutic target for breast cancer. International Journal of Oncology, 64, 43. https://doi.org/10.3892/ijo.2024.5631
MLA
Mbugua, R. W., Takano, A., Tsevegjav, B., Yokose, T., Yamashita, T., Miyagi, Y., Daigo, Y."Characterization of KIF20B as a novel prognostic biomarker and therapeutic target for breast cancer". International Journal of Oncology 64.4 (2024): 43.
Chicago
Mbugua, R. W., Takano, A., Tsevegjav, B., Yokose, T., Yamashita, T., Miyagi, Y., Daigo, Y."Characterization of KIF20B as a novel prognostic biomarker and therapeutic target for breast cancer". International Journal of Oncology 64, no. 4 (2024): 43. https://doi.org/10.3892/ijo.2024.5631
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