Heterogeneity of primary and metastatic CAFs: From differential treatment outcomes to treatment opportunities (Review)

Garcia-Vicién G, Mezheyeuski A, Bañuls M, Ruiz-Roig N and Molleví DG: The Tumor microenvironment in liver metastases from colorectal carcinoma in the context of the histologic growth patterns. Int J Mol Sci. 22:15442021. View Article : Google Scholar : PubMed/NCBI

Luo F, Li J, Wu S, Wu X, Chen M, Zhong X and Liu K: Comparative profiling between primary colorectal carcinomas and metastases identifies heterogeneity on drug resistance. Oncotarget. 7:63937–63949. 2016. View Article : Google Scholar : PubMed/NCBI

Hu Z, Li Z, Ma Z and Curtis C: Multi-cancer analysis of clonality and the timing of systemic spread in paired primary tumors and metastases. Nat Genet. 52:701–708. 2020. View Article : Google Scholar : PubMed/NCBI

Korentzelos D, Clark AM and Wells A: A perspective on therapeutic pan-resistance in metastatic cancer. Int J Mol Sci. 21:73042020. View Article : Google Scholar : PubMed/NCBI

Hirata E and Sahai E: Tumor microenvironment and differential responses to therapy. Cold Spring Harb Perspect Med. 7:a0267812017. View Article : Google Scholar : PubMed/NCBI

Jiménez-Sánchez A, Memon D, Pourpe S, Veeraraghavan H, Li Y, Vargas HA, Gill MB, Park KJ, Zivanovic O, Konner J, et al: Heterogeneous tumor-immune microenvironments among differentially growing metastases in an ovarian cancer patient. Cell. 170:927–938.e20. 2017. View Article : Google Scholar : PubMed/NCBI

Mao X, Xu J, Wang W, Liang C, Hua J, Liu J, Zhang B, Meng Q, Yu X and Shi S: Crosstalk between cancer-associated fibroblasts and immune cells in the tumor microenvironment: New findings and future perspectives. Mol Cancer. 20:1312021. View Article : Google Scholar : PubMed/NCBI

Gui Y, Aguilar-Mahecha A, Krzemien U, Hosein A, Buchanan M, Lafleur J, Pollak M, Ferrario C and Basik M: Metastatic breast carcinoma-associated fibroblasts have enhanced protumorigenic properties related to increased IGF2 expression. Clin Cancer Res. 25:7229–7242. 2019. View Article : Google Scholar : PubMed/NCBI

Kalluri R: The biology and function of fibroblasts in cancer. Nat Rev Cancer. 16:582–598. 2016. View Article : Google Scholar : PubMed/NCBI

Chen X and Song E: Turning foes to friends: Targeting cancer-associated fibroblasts. Nat Rev Drug Discov. 18:99–115. 2019. View Article : Google Scholar

Park D, Sahai E and Rullan A: SnapShot: Cancer-associated fibroblasts. Cell. 181:486–486.e1. 2020. View Article : Google Scholar : PubMed/NCBI

Shen Y, Wang X, Lu J, Salfenmoser M, Wirsik NM, Schleussner N, Imle A, Freire Valls A, Radhakrishnan P, Liang J, et al: Reduction of liver metastasis stiffness improves response to bevacizumab in metastatic colorectal cancer. Cancer Cell. 37:800–817.e7. 2020. View Article : Google Scholar : PubMed/NCBI

Ziemys A, Simic V, Milosevic M, Kojic M, Liu YT and Yokoi K: Attenuated microcirculation in small metastatic tumors in murine liver. Pharmaceutics. 13:7032021. View Article : Google Scholar : PubMed/NCBI

Cox TR: The matrix in cancer. Nat Rev Cancer. 21:217–238. 2021. View Article : Google Scholar : PubMed/NCBI

Gertych A, Walts AE, Cheng K, Liu M, John J, Lester J, Karlan BY and Orsulic S: Dynamic changes in the extracellular matrix in primary, metastatic, and recurrent ovarian cancers. Cells. 11:73692022. View Article : Google Scholar

Fujimori D, Kinoshita J, Yamaguchi T, Nakamura Y, Gunjigake K, Ohama T, Sato K, Yamamoto M, Tsukamoto T, Nomura S, et al: Established fibrous peritoneal metastasis in an immunocompetent mouse model similar to clinical immune microenvironment of gastric cancer. BMC Cancer. 20:10142020. View Article : Google Scholar : PubMed/NCBI

Wang Z, Liu J, Huang H, Ye M, Li X, Wu R, Liu H and Song Y: Metastasis-associated fibroblasts: an emerging target for metastatic cancer. Biomark Res. 9:472021. View Article : Google Scholar : PubMed/NCBI

Biffi G and Tuveson DA: Diversity and biology of cancer-associated fibroblasts. Physiol Rev. 101:147–176. 2021. View Article : Google Scholar :

Miyashita N and Saito A: Organ specificity and heterogeneity of cancer-associated fibroblasts in colorectal cancer. Int J Mol Sci. 22:109732021. View Article : Google Scholar : PubMed/NCBI

Sahai E, Astsaturov I, Cukierman E, DeNardo DG, Egeblad M, Evans RM, Fearon D, Greten FR, Hingorani SR, Hunter T, et al: A framework for advancing our understanding of cancer-associated fibroblasts. Nat Rev Cancer. 20:174–186. 2020. View Article : Google Scholar : PubMed/NCBI

Ganguly D, Chandra R, Karalis J, Teke M, Aguilera T, Maddipati R, Wachsmann MB, Ghersi D, Siravegna G, Zeh HJ III, et al: Cancer-associated fibroblasts: versatile players in the tumor microenvironment. Cancers (Basel). 12:26522020. View Article : Google Scholar : PubMed/NCBI

Bu L, Baba H, Yoshida N, Miyake K, Yasuda T, Uchihara T, Tan P and Ishimoto T: Biological heterogeneity and versatility of cancer-associated fibroblasts in the tumor microenvironment. Oncogene. 38:4887–4901. 2019. View Article : Google Scholar : PubMed/NCBI

Bartoschek M, Oskolkov N, Bocci M, Lövrot J, Larsson C, Sommarin M, Madsen CD, Lindgren D, Pekar G, Karlsson G, et al: Spatially and functionally distinct subclasses of breast cancer-associated fibroblasts revealed by single cell RNA sequencing. Nat Commun. 9:51502018. View Article : Google Scholar : PubMed/NCBI

Potenta S, Zeisberg E and Kalluri R: The role of endothelial-to-mesenchymal transition in cancer progression. Br J Cancer. 99:1375–1379. 2008. View Article : Google Scholar : PubMed/NCBI

Quante M, Tu SP, Tomita H, Gonda T, Wang SS, Takashi S, Baik GH, Shibata W, Diprete B, Betz KS, et al: Bone marrow-derived myofibroblasts contribute to the mesenchymal stem cell niche and promote tumor growth. Cancer Cell. 19:257–272. 2011. View Article : Google Scholar : PubMed/NCBI

Rhim AD, Mirek ET, Aiello NM, Maitra A, Bailey JM, McAllister F, Reichert M, Beatty GL, Rustgi AK, Vonderheide RH, et al: EMT and dissemination precede pancreatic tumor formation. Cell. 148:349–361. 2012. View Article : Google Scholar : PubMed/NCBI

Dulauroy S, Di Carlo SE, Langa F, Eberl G and Peduto L: Lineage tracing and genetic ablation of ADAM12(+) perivascular cells identify a major source of profibrotic cells during acute tissue injury. Nat Med. 18:1262–1270. 2012. View Article : Google Scholar : PubMed/NCBI

Rinkevich Y, Mori T, Sahoo D, Xu PX, Bermingham JR Jr and Weissman IL: Identification and prospective isolation of a mesothelial precursor lineage giving rise to smooth muscle cells and fibroblasts for mammalian internal organs, and their vasculature. Nat Cell Biol. 14:1251–1260. 2012. View Article : Google Scholar : PubMed/NCBI

Liu T, Han C, Wang S, Fang P, Ma Z, Xu L and Yin R: Cancer-associated fibroblasts: An emerging target of anti-cancer immunotherapy. J Hematol Oncol. 12:862019. View Article : Google Scholar : PubMed/NCBI

Bielczyk-Maczynska E: White adipocyte plasticity in physiology and disease. Cells. 8:15072019. View Article : Google Scholar : PubMed/NCBI

Huang X, He C, Hua X, Kan A, Mao Y, Sun S, Duan F, Wang J, Huang P and Li S: Oxidative stress induces monocyte-to-myofibroblast transdifferentiation through p38 in pancreatic ductal adenocarcinoma. Clin Transl Med. 10:e412020. View Article : Google Scholar : PubMed/NCBI

Yamamoto G, Taura K, Iwaisako K, Asagiri M, Ito S, Koyama Y, Tanabe K, Iguchi K, Satoh M, Nishio T, et al: Pancreatic stellate cells have distinct characteristics from hepatic stellate cells and are not the unique origin of collagen-producing cells in the pancreas. Pancreas. 46:1141–1151. 2017. View Article : Google Scholar : PubMed/NCBI

Bachem MG, Schünemann M, Ramadani M, Siech M, Beger H, Buck A, Zhou S, Schmid-Kotsas A and Adler G: Pancreatic carcinoma cells induce fibrosis by stimulating proliferation and matrix synthesis of stellate cells. Gastroenterology. 128:907–921. 2005. View Article : Google Scholar : PubMed/NCBI

Erez N: Fibroblasts form a hospitable metastatic niche in the liver. Nat Cell Biol. 18:465–466. 2016. View Article : Google Scholar : PubMed/NCBI

Bhattacharjee S, Hamberger F, Ravichandra A, Miller M, Nair A, Affo S, Filliol A, Chin L, Savage TM, Yin D, et al: Tumor restriction by type I collagen opposes tumor-promoting effects of cancer-associated fibroblasts. J Clin Invest. 131:e1469872021. View Article : Google Scholar : PubMed/NCBI

Omary MB, Lugea A, Lowe AW and Pandol SJ: The pancreatic stellate cell: A star on the rise in pancreatic diseases. J Clin Invest. 117:50–59. 2007. View Article : Google Scholar : PubMed/NCBI

Kisseleva T: The origin of fibrogenic myofibroblasts in fibrotic liver. Hepatology. 65:1039–1043. 2017. View Article : Google Scholar

Klopp AH, Spaeth EL, Dembinski JL, Woodward WA, Munshi A, Meyn RE, Cox JD, Andreeff M and Marini FC: Tumor irradiation increases the recruitment of circulating mesenchymal stem cells into the tumor microenvironment. Cancer Res. 67:11687–11695. 2007. View Article : Google Scholar : PubMed/NCBI

Spaeth EL, Dembinski JL, Sasser AK, Watson K, Klopp A, Hall B, Andreeff M and Marini F: Mesenchymal stem cell transition to tumor-associated fibroblasts contributes to fibrovascular network expansion and tumor progression. PLoS One. 4:e49922009. View Article : Google Scholar : PubMed/NCBI

Mi Z, Bhattacharya SD, Kim VM, Guo H, Talbot LJ and Kuo PC: Osteopontin promotes CCL5-mesenchymal stromal cell-mediated breast cancer metastasis. Carcinogenesis. 32:477–487. 2011. View Article : Google Scholar : PubMed/NCBI

Raz Y, Cohen N, Shani O, Bell RE, Novitskiy SV, Abramovitz L, Levy C, Milyavsky M, Leider-Trejo L, Moses HL, et al: Bone marrow-derived fibroblasts are a functionally distinct stromal cell population in breast cancer. J Exp Med. 215:3075–3093. 2018. View Article : Google Scholar : PubMed/NCBI

Liu Z, Wang H, He J, Yuan X and Sun W: Rictor ablation in BMSCs inhibits bone metastasis of TM40D cells by attenuating osteolytic destruction and CAF formation. Int J Biol Sci. 15:2448–2460. 2019. View Article : Google Scholar : PubMed/NCBI

Jiang Z, Zhou J, Li L, Liao S, He J, Zhou S and Zhou Y: Pericytes in the tumor microenvironment. Cancer Lett. 556:2160742023. View Article : Google Scholar : PubMed/NCBI

Hosaka K, Yang Y, Seki T, Fischer C, Dubey O, Fredlund E, Hartman J, Religa P, Morikawa H, Ishii Y, et al: Pericyte-fibroblast transition promotes tumor growth and metastasis. Proc Natl Acad Sci USA. 113:E5618–E5627. 2016. View Article : Google Scholar : PubMed/NCBI

Bakir B, Chiarella AM, Pitarresi JR and Rustgi AK: EMT, MET, plasticity, and tumor metastasis. Trends Cell Biol. 30:764–776. 2020. View Article : Google Scholar : PubMed/NCBI

Erez N, Truitt M, Olson P, Arron ST and Hanahan D: Cancer-associated fibroblasts are activated in incipient neoplasia to orchestrate tumor-promoting inflammation in an NF-kappaB-dependent manner. Cancer Cell. 17:135–147. 2010. View Article : Google Scholar : PubMed/NCBI

Sharon Y, Raz Y, Cohen N, Ben-Shmuel A, Schwartz H, Geiger T and Erez N: Tumor-derived osteopontin reprograms normal mammary fibroblasts to promote inflammation and tumor growth in breast cancer. Cancer Res. 75:963–973. 2015. View Article : Google Scholar : PubMed/NCBI

Vu LT, Peng B, Zhang DX, Ma V, Mathey-Andrews CA, Lam CK, Kiomourtzis T, Jin J, McReynolds L, Huang L, et al: Tumor-secreted extracellular vesicles promote the activation of cancer-associated fibroblasts via the transfer of microRNA-125b. J Extracell Vesicles. 8:15996802019. View Article : Google Scholar : PubMed/NCBI

Gong Z, Li Q, Shi J, Wei J, Li P, Chang CH, Shultz LD and Ren G: Lung fibroblasts facilitate pre-metastatic niche formation by remodeling the local immune microenvironment. Immunity. 55:1483–1500.e9. 2022. View Article : Google Scholar : PubMed/NCBI

D'Arcangelo E, Wu NC, Cadavid JL and McGuigan AP: The life cycle of cancer-associated fibroblasts within the tumour stroma and its importance in disease outcome. Br J Cancer. 122:931–942. 2020. View Article : Google Scholar : PubMed/NCBI

Koliaraki V, Pallangyo CK, Greten FR and Kollias G: Mesenchymal cells in colon cancer. Gastroenterology. 152:964–979. 2017. View Article : Google Scholar : PubMed/NCBI

Hawinkels LJAC, Paauwe M, Verspaget HW, Wiercinska E, van der Zon JM, van der Ploeg K, Koelink PJ, Lindeman JHN, Mesker W, ten Dijke P and Sier CFM: Interaction with colon cancer cells hyperactivates TGF-β signaling in cancer-associated fibroblasts. Oncogene. 33:97–107. 2014. View Article : Google Scholar

Kobayashi H, Gieniec KA, Lannagan TRM, Wang T, Asai N, Mizutani Y, Iida T, Ando R, Thomas EM, Sakai A, et al: The origin and contribution of cancer-associated fibroblasts in colorectal carcinogenesis. Gastroenterology. 162:890–906. 2022. View Article : Google Scholar

Shinagawa K, Kitadai Y, Tanaka M, Sumida T, Kodama M, Higashi Y, Tanaka S, Yasui W and Chayama K: Mesenchymal stem cells enhance growth and metastasis of colon cancer. Int J Cancer. 127:2323–2333. 2010. View Article : Google Scholar : PubMed/NCBI

Flier SN, Tanjore H, Kokkotou EG, Sugimoto H, Zeisberg M and Kalluri R: Identification of epithelial to mesenchymal transition as a novel source of fibroblasts in intestinal fibrosis. J Biol Chem. 285:20202–20212. 2010. View Article : Google Scholar : PubMed/NCBI

Apte MV, Park S, Phillips PA, Santucci N, Goldstein D, Kumar RK, Ramm GA, Buchler M, Friess H, McCarroll JA, et al: Desmoplastic reaction in pancreatic cancer: Role of pancreatic stellate cells. Pancreas. 29:179–187. 2004. View Article : Google Scholar : PubMed/NCBI

Houg DS and Bijlsma MF: The hepatic pre-metastatic niche in pancreatic ductal adenocarcinoma. Mol Cancer. 17:952018. View Article : Google Scholar : PubMed/NCBI

Öhlund D, Handly-Santana A, Biffi G, Elyada E, Almeida AS, Ponz-Sarvise M, Corbo V, Oni TE, Hearn SA, Lee EJ, et al: Distinct populations of inflammatory fibroblasts and myofibroblasts in pancreatic cancer. J Exp Med. 214:579–596. 2017. View Article : Google Scholar : PubMed/NCBI

Elyada E, Bolisetty M, Laise P, Flynn WF, Courtois ET, Burkhart RA, Teinor JA, Belleau P, Biffi G, Lucito MS, et al: Cross-species single-cell analysis of pancreatic ductal adenocarcinoma reveals antigen-presenting cancer-associated fibroblasts. Cancer Discov. 9:1102–1123. 2019. View Article : Google Scholar : PubMed/NCBI

Tsoumakidou M: The advent of immune stimulating CAFs in cancer. Nat Rev Cancer. 23:258–269. 2023. View Article : Google Scholar : PubMed/NCBI

Dominguez CX, Müller S, Keerthivasan S, Koeppen H, Hung J, Gierke S, Breart B, Foreman O, Bainbridge TW, Castiglioni A, et al: Single-cell RNA sequencing reveals stromal evolution into LRRC15⁺ myofibroblasts as a determinant of patient response to cancer immunotherapy. Cancer Discov. 10:232–253. 2020. View Article : Google Scholar

Huang H, Wang Z, Zhang Y, Pradhan RN, Ganguly D, Chandra R, Murimwa G, Wright S, Gu X, Maddipati R, et al: Mesothelial cell-derived antigen-presenting cancer-associated fibroblasts induce expansion of regulatory T cells in pancreatic cancer. Cancer Cell. 40:656–673.e7. 2022. View Article : Google Scholar :

Iwaisako K, Jiang C, Zhang M, Cong M, Moore-Morris TJ, Park TJ, Liu X, Xu J, Wang P, Paik YH, et al: Origin of myofibroblasts in the fibrotic liver in mice. Proc Natl Acad Sci USA. 111:E3297–E3305. 2014. View Article : Google Scholar : PubMed/NCBI

Lua I, Li Y, Zagory JA, Wang KS, French SW, Sévigny J and Asahina K: Characterization of hepatic stellate cells, portal fibroblasts, and mesothelial cells in normal and fibrotic livers. J Hepatol. 64:1137–1146. 2016. View Article : Google Scholar : PubMed/NCBI

Tsuchida T and Friedman SL: Mechanisms of hepatic stellate cell activation. Nat Rev Gastroenterol Hepatol. 14:397–411. 2017. View Article : Google Scholar : PubMed/NCBI

O'Hara SP and LaRusso NF: Portal fibroblasts: A renewable source of liver myofibroblasts. Hepatology. 76:1240–1242. 2022. View Article : Google Scholar : PubMed/NCBI

Xie Z, Gao Y, Ho C, Li L, Jin C, Wang X, Zou C, Mao Y, Wang X, Li Q, et al: Exosome-delivered CD44v6/C1QBP complex drives pancreatic cancer liver metastasis by promoting fibrotic liver microenvironment. Gut. 71:568–579. 2022. View Article : Google Scholar

Giguelay A, Turtoi E, Khelaf L, Tosato G, Dadi I, Chastel T, Poul MA, Pratlong M, Nicolescu S, Severac D, et al: The landscape of cancer-associated fibroblasts in colorectal cancer liver metastases. Theranostics. 12:7624–7639. 2022. View Article : Google Scholar : PubMed/NCBI

Tan HX, Gong WZ, Zhou K, Xiao ZG, Hou FT, Huang T, Zhang L, Dong HY, Zhang WL, Liu Y and Huang ZC: CXCR4/TGF-β1 mediated hepatic stellate cells differentiation into carcinoma-associated fibroblasts and promoted liver metastasis of colon cancer. Cancer Biol Ther. 21:258–268. 2020. View Article : Google Scholar

Mukaida N, Zhang D and Sasaki SI: Emergence of cancer-associated fibroblasts as an indispensable cellular player in bone metastasis process. Cancers (Basel). 12:28962020. View Article : Google Scholar : PubMed/NCBI

Houthuijzen JM and de Visser KE: The lung fibroblast as 'soil fertilizer' in breast cancer metastasis. Immunity. 55:1336–1339. 2022. View Article : Google Scholar : PubMed/NCBI

Chang HY, Chi JT, Dudoit S, Bondre C, van de Rijn M, Botstein D and Brown PO: Diversity, topographic differentiation, and positional memory in human fibroblasts. Proc Natl Acad Sci USA. 99:12877–12882. 2002. View Article : Google Scholar : PubMed/NCBI

Apte MV, Wilson JS, Lugea A and Pandol SJ: A starring role for stellate cells in the pancreatic cancer microenvironment. Gastroenterology. 144:1210–1219. 2013. View Article : Google Scholar : PubMed/NCBI

Hessmann E, Patzak MS, Klein L, Chen N, Kari V, Ramu I, Bapiro TE, Frese KK, Gopinathan A, Richards FM, et al: Fibroblast drug scavenging increases intratumoural gemcitabine accumulation in murine pancreas cancer. Gut. 67:497–507. 2018. View Article : Google Scholar

Helms EJ, Berry MW, Chaw RC, DuFort CC, Sun D, Onate MK, Oon C, Bhattacharyya S, Sanford-Crane H, Horton W, et al: Mesenchymal lineage heterogeneity underlies nonredundant functions of pancreatic cancer-associated fibroblasts. Cancer Discov. 12:484–501. 2022. View Article : Google Scholar

Garcia PE, Adoumie M, Kim EC, Zhang Y, Scales MK, El-Tawil YS, Shaikh AZ, Wen HJ, Bednar F, Allen BL, et al: Differential contribution of pancreatic fibroblast subsets to the pancreatic cancer stroma. Cell Mol Gastroenterol Hepatol. 10:581–599. 2020. View Article : Google Scholar : PubMed/NCBI

Zhang Y, Bian Y, Wang Y, Wang Y, Duan X, Han Y, Zhang L, Wang F, Gu Z and Qin Z: HIF-1α is necessary for activation and tumour-promotion effect of cancer-associated fibroblasts in lung cancer. J Cell Mol Med. 25:5457–5469. 2021. View Article : Google Scholar : PubMed/NCBI

Shintani Y, Fujiwara A, Kimura T, Kawamura T, Funaki S, Minami M and Okumura M: IL-6 secreted from cancer-associated fibroblasts mediates chemoresistance in NSCLC by increasing epithelial-mesenchymal transition signaling. J Thorac Oncol. 11:1482–1492. 2016. View Article : Google Scholar : PubMed/NCBI

Gottschling S, Granzow M, Kuner R, Jauch A, Herpel E, Xu EC, Muley T, Schnabel PA, Herth FJ and Meister M: Mesenchymal stem cells in non-small cell lung cancer-different from others? Insights from comparative molecular and functional analyses. Lung Cancer. 80:19–29. 2013. View Article : Google Scholar : PubMed/NCBI

Wang H, Shui L, Chen R and Chen Y, Guo J and Chen Y: Occurrence and prognosis of lung cancer metastasis to major organs: A population-based study. Eur J Cancer Prev. 32:246–253. 2023. View Article : Google Scholar : PubMed/NCBI

Kong J, Tian H, Zhang F, Zhang Z, Li J, Liu X, Li X, Liu J, Li X, Jin D, et al: Extracellular vesicles of carcinoma-associated fibroblasts creates a pre-metastatic niche in the lung through activating fibroblasts. Mol Cancer. 18:1752019. View Article : Google Scholar : PubMed/NCBI

Duda DG, Duyverman AM, Kohno M, Snuderl M, Steller EJ, Fukumura D and Jain RK: Malignant cells facilitate lung metastasis by bringing their own soil. Proc Natl Acad Sci USA. 107:21677–21682. 2010. View Article : Google Scholar : PubMed/NCBI

Buchsbaum RJ and Oh SY: Breast cancer-associated fibroblasts: Where We Are And Where We Need To Go. Cancers (Basel). 8:192016. View Article : Google Scholar : PubMed/NCBI

Hu D, Li Z, Zheng B, Lin X, Pan Y, Gong P, Zhuo W, Hu Y, Chen C, Chen L, et al: Cancer-associated fibroblasts in breast cancer: Challenges and opportunities. Cancer Commun (Lond). 42:401–434. 2022. View Article : Google Scholar : PubMed/NCBI

Friedman G, Levi-Galibov O, David E, Bornstein C, Giladi A, Dadiani M, Mayo A, Halperin C, Pevsner-Fischer M, Lavon H, et al: Cancer-associated fibroblast compositions change with breast cancer progression linking the ratio of S100A4⁺ and PDPN⁺ CAFs to clinical outcome. Nat Cancer. 1:692–708. 2020. View Article : Google Scholar : PubMed/NCBI

Zhang XHF, Jin X, Malladi S, Zou Y, Wen YH, Brogi E, Smid M, Foekens JA and Massagué J: Selection of bone metastasis seeds by mesenchymal signals in the primary tumor stroma. Cell. 154:1060–1073. 2013. View Article : Google Scholar : PubMed/NCBI

Kuo MC, Kothari AN, Kuo PC and Mi Z: Cancer stemness in bone marrow micrometastases of human breast cancer. Surgery. 163:330–335. 2018. View Article : Google Scholar

Ban J, Fock V, Aryee DNT and Kovar H: Mechanisms, diagnosis and treatment of bone metastases. Cells. 10:29442021. View Article : Google Scholar : PubMed/NCBI

Haider MT, Smit DJ and Taipaleenmäki H: The endosteal niche in breast cancer bone metastasis. Front Oncol. 10:3352020. View Article : Google Scholar : PubMed/NCBI

Croucher PI, McDonald MM and Martin TJ: Bone metastasis: The importance of the neighbourhood. Nat Rev Cancer. 16:373–386. 2016. View Article : Google Scholar : PubMed/NCBI

Cassell K, Thomas-Lopez D, Kjelsø C and Uldum S: Provincial trends in Legionnaires' disease are not explained by population structure in Denmark, 2015 to 2018. Euro Surveill. 26:20000362021. View Article : Google Scholar : PubMed/NCBI

Mundim FGL, Pasini FS, Nonogaki S, Rocha RM, Soares FA, Brentani MM and Logullo AF: Breast carcinoma-associated fibroblasts share similar biomarker profiles in matched lymph node metastasis. Appl Immunohistochem Mol Morphol. 24:712–720. 2016. View Article : Google Scholar : PubMed/NCBI

Del Valle PR, Milani C, Brentani MM, Katayama ML, de Lyra EC, Carraro DM, Brentani H, Puga R, Lima LA, Rozenchan PB, et al: Transcriptional profile of fibroblasts obtained from the primary site, lymph node and bone marrow of breast cancer patients. Genet Mol Biol. 37:480–489. 2014. View Article : Google Scholar : PubMed/NCBI

Puram SV, Tirosh I, Parikh AS, Patel AP, Yizhak K, Gillespie S, Rodman C, Luo CL, Mroz EA, Emerick KS, et al: Single-cell transcriptomic analysis of primary and metastatic tumor ecosystems in head and neck cancer. Cell. 171:1611–1624.e24. 2017. View Article : Google Scholar : PubMed/NCBI

Han L, Wu Y, Fang K, Sweeney S, Roesner UK, Parrish M, Patel K, Walter T, Piermattei J, Trimboli A, et al: The splanchnic mesenchyme is the tissue of origin for pancreatic fibroblasts during homeostasis and tumorigenesis. Nat Commun. 14:12023. View Article : Google Scholar : PubMed/NCBI

Nielsen SR, Quaranta V, Linford A, Emeagi P, Rainer C, Santos A, Ireland L, Sakai T, Sakai K, Kim YS, et al: Macrophage-secreted granulin supports pancreatic cancer metastasis by inducing liver fibrosis. Nat Cell Biol. 18:549–560. 2016. View Article : Google Scholar : PubMed/NCBI

Zhang C, Wang XY, Zhang P, He TC, Han JH, Zhang R, Lin J, Fan J, Lu L, Zhu WW, et al: Cancer-derived exosomal HSPC111 promotes colorectal cancer liver metastasis by reprogramming lipid metabolism in cancer-associated fibroblasts. Cell Death Dis. 13:572022. View Article : Google Scholar : PubMed/NCBI

Calon A, Espinet E, Palomo-Ponce S, Tauriello DV, Iglesias M, Céspedes MV, Sevillano M, Nadal C, Jung P, Zhang XH, et al: Dependency of colorectal cancer on a TGF-β-driven program in stromal cells for metastasis initiation. Cancer Cell. 22:571–584. 2012. View Article : Google Scholar : PubMed/NCBI

Shi M, Zhu J, Wang R, Chen X, Mi L, Walz T and Springer TA: Latent TGF-β structure and activation. Nature. 474:343–349. 2011. View Article : Google Scholar : PubMed/NCBI

Massagué J: TGFbeta signalling in context. Nat Rev Mol Cell Biol. 13:616–630. 2012. View Article : Google Scholar

Su J, Morgani SM, David CJ, Wang Q, Er EE, Huang YH, Basnet H, Zou Y, Shu W, Soni RK, et al: TGF-β orchestrates fibrogenic and developmental EMTs via the RAS effector RREB1. Nature. 577:566–571. 2020. View Article : Google Scholar : PubMed/NCBI

Kojima Y, Acar A, Eaton EN, Mellody KT, Scheel C, Ben-Porath I, Onder TT, Wang ZC, Richardson AL, Weinberg RA and Orimo A: Autocrine TGF-beta and stromal cell-derived factor-1 (SDF-1) signaling drives the evolution of tumor-promoting mammary stromal myofibroblasts. Proc Natl Acad Sci USA. 107:20009–20014. 2010. View Article : Google Scholar : PubMed/NCBI

Chen IX, Chauhan VP, Posada J, Ng MR, Wu MW, Adstamongkonkul P, Huang P, Lindeman N, Langer R and Jain RK: Blocking CXCR4 alleviates desmoplasia, increases T-lymphocyte infiltration, and improves immunotherapy in metastatic breast cancer. Proc Natl Acad Sci USA. 116:4558–4566. 2019. View Article : Google Scholar : PubMed/NCBI

Eckert MA, Coscia F, Chryplewicz A, Chang JW, Hernandez KM, Pan S, Tienda SM, Nahotko DA, Li G, Blaženović I, et al: Proteomics reveals NNMT as a master metabolic regulator of cancer-associated fibroblasts. Nature. 569:723–728. 2019. View Article : Google Scholar : PubMed/NCBI

Biffi G, Oni TE, Spielman B, Hao Y, Elyada E, Park Y, Preall J and Tuveson DA: IL1-induced JAK/STAT signaling is antagonized by TGFβ to shape CAF heterogeneity in pancreatic ductal adenocarcinoma. Cancer Discov. 9:282–301. 2019. View Article : Google Scholar

Chen Y, McAndrews KM and Kalluri R: Clinical and therapeutic relevance of cancer-associated fibroblasts. Nat Rev Clin Oncol. 18:792–804. 2021. View Article : Google Scholar : PubMed/NCBI

Maehira H, Miyake T, Iida H, Tokuda A, Mori H, Yasukawa D, Mukaisho KI, Shimizu T and Tani M: Vimentin expression in tumor microenvironment predicts survival in pancreatic ductal adenocarcinoma: Heterogeneity in fibroblast population. Ann Surg Oncol. 26:4791–4804. 2019. View Article : Google Scholar : PubMed/NCBI

Paulsson J and Micke P: Prognostic relevance of cancer-associated fibroblasts in human cancer. Semin Cancer Biol. 25:61–68. 2014. View Article : Google Scholar : PubMed/NCBI

Kim HM, Jung WH and Koo JS: Expression of cancer-associated fibroblast related proteins in metastatic breast cancer: An immunohistochemical analysis. J Transl Med. 13:2222015. View Article : Google Scholar : PubMed/NCBI

Koerber SA, Staudinger F, Kratochwil C, Adeberg S, Haefner MF, Ungerechts G, Rathke H, Winter E, Lindner T, Syed M, et al: The role of ⁶⁸Ga-FAPI PET/CT for patients with malignancies of the lower gastrointestinal tract: First clinical experience. J Nucl Med. 61:1331–1336. 2020. View Article : Google Scholar : PubMed/NCBI

Altmann A, Haberkorn U and Siveke J: The latest developments in imaging of fibroblast activation protein. J Nucl Med. 62:160–167. 2021. View Article : Google Scholar

Imlimthan S, Moon ES, Rathke H, Afshar-Oromieh A, Rösch F, Rominger A and Gourni E: New frontiers in cancer imaging and therapy based on radiolabeled fibroblast activation protein inhibitors: A rational review and current progress. Pharmaceuticals (Basel). 14:10232021. View Article : Google Scholar : PubMed/NCBI

Zhao L, Chen J, Pang Y, Fu K, Shang Q, Wu H, Sun L, Lin Q and Chen H: Fibroblast activation protein-based theranostics in cancer research: A state-of-the-art review. Theranostics. 12:1557–1569. 2022. View Article : Google Scholar : PubMed/NCBI

Zubaľ M, Výmolová B, Matrasová I, Výmola P, Vepřková J, Syrůček M, Tomáš R, Vaníčková Z, Křepela E, Konečná D, et al: Fibroblast activation protein as a potential theranostic target in brain metastases of diverse solid tumours. Pathology. 55:806–817. 2023. View Article : Google Scholar

Peltier A, Seban RD, Buvat I, Bidard FC and Mechta-Grigoriou F: Fibroblast heterogeneity in solid tumors: From single cell analysis to whole-body imaging. Semin Cancer Biol. 86:262–272. 2022. View Article : Google Scholar : PubMed/NCBI

Taralli S, Lorusso M, Perrone E, Perotti G, Zagaria L and Calcagni ML: PET/CT with fibroblast activation protein inhibitors in breast cancer: Diagnostic and theranostic application-A literature review. Cancers (Basel). 15:9082023. View Article : Google Scholar : PubMed/NCBI

Dong Y, Zhou H, Alhaskawi A, Wang Z, Lai J, Yao C, Liu Z, Hasan Abdullah Ezzi S, Goutham Kota V, Hasan Abdulla Hasan Abdulla M and Lu H: The superiority of fibroblast activation protein inhibitor (FAPI) PET/CT versus FDG PET/CT in the diagnosis of various malignancies. Cancers (Basel). 15:11932023. View Article : Google Scholar : PubMed/NCBI

Serfling S, Zhi Y, Schirbel A, Lindner T, Meyer T, Gerhard-Hartmann E, Lapa C, Hagen R, Hackenberg S, Buck AK and Scherzad A: Improved cancer detection in Waldeyer's tonsillar ring by ⁶⁸Ga-FAPI PET/CT imaging. Eur J Nucl Med Mol Imaging. 48:1178–1187. 2021. View Article : Google Scholar

Mona CE, Benz MR, Hikmat F, Grogan TR, Lueckerath K, Razmaria A, Riahi R, Slavik R, Girgis MD, Carlucci G, et al: Correlation of ⁶⁸Ga-FAPi-46 PET biodistribution with FAP expression by immunohistochemistry in patients with solid cancers: Interim analysis of a prospective translational exploratory study. J Nucl Med. 63:1021–1026. 2022. View Article : Google Scholar :

Sollini M, Kirienko M, Gelardi F, Fiz F, Gozzi N and Chiti A: State-of-the-art of FAPI-PET imaging: A systematic review and meta-analysis. Eur J Nucl Med Mol Imaging. 48:4396–4414. 2021. View Article : Google Scholar : PubMed/NCBI

Yazdani S, Bansal R and Prakash J: Drug targeting to myofibroblasts: Implications for fibrosis and cancer. Adv Drug Deliv Rev. 121:101–116. 2017. View Article : Google Scholar : PubMed/NCBI

Becker LM, O'Connell JT, Vo AP, Cain MP, Tampe D, Bizarro L, Sugimoto H, McGow AK, Asara JM, Lovisa S, et al: Epigenetic reprogramming of cancer-associated fibroblasts deregulates glucose metabolism and facilitates progression of breast cancer. Cell Rep. 31:1077012020. View Article : Google Scholar : PubMed/NCBI

Muchlińska A, Nagel A, Popęda M, Szade J, Niemira M, Zieliński J, Skokowski J, Bednarz-Knoll N and Żaczek AJ: Alpha-smooth muscle actin-positive cancer-associated fibroblasts secreting osteopontin promote growth of luminal breast cancer. Cell Mol Biol Lett. 27:452022. View Article : Google Scholar

Kwak Y, Lee HE, Kim WH, Kim DW, Kang SB and Lee HS: The clinical implication of cancer-associated microvasculature and fibroblast in advanced colorectal cancer patients with synchronous or metachronous metastases. PLoS One. 9:e918112014. View Article : Google Scholar : PubMed/NCBI

Itou RA, Uyama N, Hirota S, Kawada N, Wu S, Miyashita S, Nakamura I, Suzumura K, Sueoka H, Okada T, et al: Immunohistochemical characterization of cancer-associated fibroblasts at the primary sites and in the metastatic lymph nodes of human intrahepatic cholangiocarcinoma. Hum Pathol. 83:77–89. 2019. View Article : Google Scholar

Borriello L, Nakata R, Sheard MA, Fernandez GE, Sposto R, Malvar J, Blavier L, Shimada H, Asgharzadeh S, Seeger RC and DeClerck YA: Cancer-associated fibroblasts share characteristics and protumorigenic activity with mesenchymal stromal cells. Cancer Res. 77:5142–5157. 2017. View Article : Google Scholar : PubMed/NCBI

Zhang J, Chen L, Liu X, Kammertoens T, Blankenstein T and Qin Z: Fibroblast-specific protein 1/S100A4-positive cells prevent carcinoma through collagen production and encapsulation of carcinogens. Cancer Res. 73:2770–2781. 2013. View Article : Google Scholar : PubMed/NCBI

Shindo K, Aishima S, Ohuchida K, Fujiwara K, Fujino M, Mizuuchi Y, Hattori M, Mizumoto K, Tanaka M and Oda Y: Podoplanin expression in cancer-associated fibroblasts enhances tumor progression of invasive ductal carcinoma of the pancreas. Mol Cancer. 12:1682013. View Article : Google Scholar : PubMed/NCBI

Kubouchi Y, Yurugi Y, Wakahara M, Sakabe T, Haruki T, Nosaka K, Miwa K, Araki K, Taniguchi Y, Shiomi T, et al: Podoplanin expression in cancer-associated fibroblasts predicts unfavourable prognosis in patients with pathological stage IA lung adenocarcinoma. Histopathology. 72:490–499. 2018. View Article : Google Scholar

Zhou Q, Wang Z, Zeng H, Zhang H, Liu Z, Huang Q, Wang J, Chang Y, Bai Q, Liu L, et al: Identification and validation of poor prognosis immunoevasive subtype of muscle-invasive bladder cancer with tumor-infiltrating podoplanin⁺ cell abundance. Oncoimmunology. 9:17473332020. View Article : Google Scholar

Wang P, Song L, Ge H, Jin P, Jiang Y, Hu W and Geng N: Crenolanib, a PDGFR inhibitor, suppresses lung cancer cell proliferation and inhibits tumor growth in vivo. Onco Targets Ther. 7:1761–1768. 2014. View Article : Google Scholar : PubMed/NCBI

Matsuwaki R, Ishii G, Zenke Y, Neri S, Aokage K, Hishida T, Yoshida J, Fujii S, Kondo H, Goya T, et al: Immunophenotypic features of metastatic lymph node tumors to predict recurrence in N2 lung squamous cell carcinoma. Cancer Sci. 105:905–911. 2014. View Article : Google Scholar : PubMed/NCBI

Lavie D, Ben-Shmuel A, Erez N and Scherz-Shouval R: Cancer-associated fibroblasts in the single-cell era. Nat Cancer. 3:793–807. 2022. View Article : Google Scholar : PubMed/NCBI

Zhang X, Zhu R, Yu D, Wang J, Yan Y and Xu K: Single-cell RNA sequencing to explore cancer-associated fibroblasts heterogeneity: 'Single' vision for 'heterogeneous' environment. Cell Prolif. e135922023.Epub ahead of print. View Article : Google Scholar

Li C, Wu H, Guo L, Liu D, Yang S, Li S and Hua K: Single-cell transcriptomics reveals cellular heterogeneity and molecular stratification of cervical cancer. Commun Biol. 5:12082022. View Article : Google Scholar : PubMed/NCBI

Li X, Sun Z, Peng G, Xiao Y, Guo J, Wu B, Li X, Zhou W, Li J, Li Z, et al: Single-cell RNA sequencing reveals a pro-invasive cancer-associated fibroblast subgroup associated with poor clinical outcomes in patients with gastric cancer. Theranostics. 12:620–638. 2022. View Article : Google Scholar : PubMed/NCBI

Guo W, Zhou B, Yang Z, Liu X, Huai Q, Guo L, Xue X, Tan F, Li Y, Xue Q, et al: Integrating microarray-based spatial transcriptomics and single-cell RNA-sequencing reveals tissue architecture in esophageal squamous cell carcinoma. EBioMedicine. 84:1042812022. View Article : Google Scholar : PubMed/NCBI

Buechler MB, Pradhan RN, Krishnamurty AT, Cox C, Calviello AK, Wang AW, Yang YA, Tam L, Caothien R, Roose-Girma M, et al: Cross-tissue organization of the fibroblast lineage. Nature. 593:575–579. 2021. View Article : Google Scholar : PubMed/NCBI

Garcia-Recio S, Hinoue T, Wheeler GL, Kelly BJ, Garrido-Castro AC, Pascual T, De Cubas AA, Xia Y, Felsheim BM, McClure MB, et al: Multiomics in primary and metastatic breast tumors from the AURORA US network finds microenvironment and epigenetic drivers of metastasis. Nat Cancer. 4:128–147. 2023.

Liu S, Suhail Y, Novin A, Perpetua L and Kshitiz: Metastatic transition of pancreatic ductal cell adenocarcinoma is accompanied by the emergence of pro-invasive cancer-associated fibroblasts. Cancers (Basel). 14:21972022. View Article : Google Scholar : PubMed/NCBI

Hill M and Tran N: MicroRNAs regulating MicroRNAs in cancer. Trends Cancer. 4:465–468. 2018. View Article : Google Scholar : PubMed/NCBI

Tkach M and Théry C: Communication by extracellular vesicles: Where we are and where we need to go. Cell. 164:1226–1232. 2016. View Article : Google Scholar : PubMed/NCBI

Vivacqua A, Muoio MG, Miglietta AM and Maggiolini M: Differential MicroRNA landscape triggered by estrogens in cancer associated fibroblasts (CAFs) of primary and metastatic breast tumors. Cancers (Basel). 11:4122019. View Article : Google Scholar : PubMed/NCBI

Lee KS, Nam SK, Koh J, Kim DW, Kang SB, Choe G, Kim WH and Lee HS: Stromal expression of MicroRNA-21 in advanced colorectal cancer patients with distant metastases. J Pathol Transl Med. 50:270–277. 2016. View Article : Google Scholar : PubMed/NCBI

Han Q, Tan S, Gong L, Li G, Wu Q, Chen L, Du S, Li W, Liu X, Cai J and Wang Z: Omental cancer-associated fibroblast-derived exosomes with low microRNA-29c-3p promote ovarian cancer peritoneal metastasis. Cancer Sci. 114:1929–1942. 2023. View Article : Google Scholar : PubMed/NCBI

Alsayed RKME, Khan AQ, Ahmad F, Ansari AW, Alam MA, Buddenkotte J, Steinhoff M, Uddin S and Ahmad A: Epigenetic regulation of CXCR4 signaling in cancer pathogenesis and progression. Semin Cancer Biol. 86:697–708. 2022. View Article : Google Scholar : PubMed/NCBI

Petit I, Jin D and Rafii S: The SDF-1-CXCR4 signaling pathway: A molecular hub modulating neo-angiogenesis. Trends Immunol. 28:299–307. 2007. View Article : Google Scholar : PubMed/NCBI

Shi Y, Riese DJ II and Shen J: The role of the CXCL12/CXCR4/CXCR7 chemokine axis in cancer. Front Pharmacol. 11:5746672020. View Article : Google Scholar : PubMed/NCBI

Dai JM, Sun K, Li C, Cheng M, Guan JH, Yang LN and Zhang LW: Cancer-associated fibroblasts contribute to cancer metastasis and apoptosis resistance in human ovarian cancer via paracrine SDF-1α. Clin Transl Oncol. 25:1606–1616. 2023. View Article : Google Scholar : PubMed/NCBI

Zhang Y, Yang P, Sun T, Li D, Xu X, Rui Y, Li C, Chong M, Ibrahim T, Mercatali L, et al: miR-126 and miR-126* repress recruitment of mesenchymal stem cells and inflammatory monocytes to inhibit breast cancer metastasis. Nat Cell Biol. 15:284–294. 2013. View Article : Google Scholar : PubMed/NCBI

Zhong B, Cheng B, Huang X, Xiao Q, Niu Z, Chen YF, Yu Q, Wang W and Wu XJ: Colorectal cancer-associated fibroblasts promote metastasis by up-regulating LRG1 through stromal IL-6/STAT3 signaling. Cell Death Dis. 13:162021. View Article : Google Scholar : PubMed/NCBI

Xie H, Lei Y, Mao Y, Lan J, Yang J, Quan H and Zhang T: FK866 inhibits colorectal cancer metastasis by reducing NAD⁺ levels in cancer-associated fibroblasts. Genes Genomics. 44:1531–1541. 2022. View Article : Google Scholar : PubMed/NCBI

Walterskirchen N, Müller C, Ramos C, Zeindl S, Stang S, Herzog D, Sachet M, Schimek V, Unger L, Gerakopoulos V, et al: Metastatic colorectal carcinoma-associated fibroblasts have immunosuppressive properties related to increased IGFBP2 expression. Cancer Lett. 540:2157372022. View Article : Google Scholar : PubMed/NCBI

Mukherjee S, Sakpal A, Mehrotra M, Phadte P, Rekhi B and Ray P: Homo and heterotypic cellular cross-talk in epithelial ovarian cancer impart pro-tumorigenic properties through differential activation of the notch3 pathway. Cancers (Basel). 14:33652022. View Article : Google Scholar : PubMed/NCBI

Pan X, Zhou J, Xiao Q, Fujiwara K, Zhang M, Mo G, Gong W and Zheng L: Cancer-associated fibroblast heterogeneity is associated with organ-specific metastasis in pancreatic ductal adenocarcinoma. J Hematol Oncol. 14:1842021. View Article : Google Scholar : PubMed/NCBI

Muhl L, Genové G, Leptidis S, Liu J, He L, Mocci G, Sun Y, Gustafsson S, Buyandelger B, Chivukula IV, et al: Single-cell analysis uncovers fibroblast heterogeneity and criteria for fibroblast and mural cell identification and discrimination. Nat Commun. 11:39532020. View Article : Google Scholar : PubMed/NCBI

Ewald CY: The matrisome during aging and longevity: A systems-level approach toward defining matreotypes promoting healthy aging. Gerontology. 66:266–274. 2020. View Article : Google Scholar

Rhim AD, Oberstein PE, Thomas DH, Mirek ET, Palermo CF, Sastra SA, Dekleva EN, Saunders T, Becerra CP, Tattersall IW, et al: Stromal elements act to restrain, rather than support, pancreatic ductal adenocarcinoma. Cancer Cell. 25:735–747. 2014. View Article : Google Scholar : PubMed/NCBI

Boyd LNC, Andini KD, Peters GJ, Kazemier G and Giovannetti E: Heterogeneity and plasticity of cancer-associated fibroblasts in the pancreatic tumor microenvironment. Semin Cancer Biol. 82:184–196. 2022. View Article : Google Scholar

von Ahrens D, Bhagat TD, Nagrath D, Maitra A and Verma A: The role of stromal cancer-associated fibroblasts in pancreatic cancer. J Hematol Oncol. 10:762017. View Article : Google Scholar : PubMed/NCBI

Deasy SK and Erez N: A glitch in the matrix: organ-specific matrisomes in metastatic niches. Trends Cell Biol. 32:110–123. 2022. View Article : Google Scholar

Elia I, Rossi M, Stegen S, Broekaert D, Doglioni G, van Gorsel M, Boon R, Escalona-Noguero C, Torrekens S, Verfaillie C, et al: Breast cancer cells rely on environmental pyruvate to shape the metastatic niche. Nature. 568:117–121. 2019. View Article : Google Scholar : PubMed/NCBI

Yuzhalin AE, Gordon-Weeks AN, Tognoli ML, Jones K, Markelc B, Konietzny R, Fischer R, Muth A, O'Neill E, Thompson PR, et al: Colorectal cancer liver metastatic growth depends on PAD4-driven citrullination of the extracellular matrix. Nat Commun. 9:47832018. View Article : Google Scholar : PubMed/NCBI

Levental KR, Yu H, Kass L, Lakins JN, Egeblad M, Erler JT, Fong SF, Csiszar K, Giaccia A, Weninger W, et al: Matrix crosslinking forces tumor progression by enhancing integrin signaling. Cell. 139:891–906. 2009. View Article : Google Scholar : PubMed/NCBI

Er EE, Valiente M, Ganesh K, Zou Y, Agrawal S, Hu J, Griscom B, Rosenblum M, Boire A, Brogi E, et al: Pericyte-like spreading by disseminated cancer cells activates YAP and MRTF for metastatic colonization. Nat Cell Biol. 20:966–978. 2018. View Article : Google Scholar : PubMed/NCBI

Che LH, Liu JW, Huo JP, Luo R, Xu RM, He C, Li YQ, Zhou AJ, Huang P, Chen YY, et al: A single-cell atlas of liver metastases of colorectal cancer reveals reprogramming of the tumor microenvironment in response to preoperative chemotherapy. Cell Discov. 7:802021. View Article : Google Scholar : PubMed/NCBI

Whatcott CJ, Diep CH, Jiang P, Watanabe A, LoBello J, Sima C, Hostetter G, Shepard HM, Von Hoff DD and Han H: Desmoplasia in primary tumors and metastatic lesions of pancreatic cancer. Clin Cancer Res. 21:3561–3568. 2015. View Article : Google Scholar : PubMed/NCBI

Placencio-Hickok VR, Lauzon M, Moshayedi N, Guan M, Kim S, Nissen N, Lo S, Pandol S, Larson BK, Gong J, et al: Hyaluronan heterogeneity in pancreatic ductal adenocarcinoma: Primary tumors compared to sites of metastasis. Pancreatology. 22:92–97. 2022. View Article : Google Scholar

Ueno H, Sekine S, Oshiro T, Kanemitsu Y, Hamaguchi T, Shida D, Takashima A, Ishiguro M, Ito E, Hashiguchi Y, et al: Disentangling the prognostic heterogeneity of stage III colorectal cancer through histologic stromal categorization. Surgery. 163:777–783. 2018. View Article : Google Scholar

Ao T, Kajiwara Y, Yonemura K, Shinto E, Mochizuki S, Okamoto K, Aosasa S and Ueno H: Prognostic significance of histological categorization of desmoplastic reaction in colorectal liver metastases. Virchows Arch. 475:341–348. 2019. View Article : Google Scholar : PubMed/NCBI

Ao T, Kajiwara Y, Yonemura K, Shinto E, Mochizuki S, Okamoto K, Kishi Y and Ueno H: Morphological consistency of desmoplastic reactions between the primary colorectal cancer lesion and associated metastatic lesions. Virchows Arch. 477:47–55. 2020. View Article : Google Scholar : PubMed/NCBI

Mayorca-Guiliani AE, Madsen CD, Cox TR, Horton ER, Venning FA and Erler JT: ISDoT: In situ decellularization of tissues for high-resolution imaging and proteomic analysis of native extracellular matrix. Nat Med. 23:890–898. 2017. View Article : Google Scholar : PubMed/NCBI

Yang H, Sun B, Fan L, Ma W, Xu K, Hall SRR, Wang Z, Schmid RA, Peng RW, Marti TM, et al: Multi-scale integrative analyses identify THBS2⁺ cancer-associated fibroblasts as a key orchestrator promoting aggressiveness in early-stage lung adenocarcinoma. Theranostics. 12:3104–3130. 2022. View Article : Google Scholar :

Irum B, Asif M, Mumtaz B and Aslam N: Effect of dental proximal restorations on periodontal health in patients. J Ayub Med Coll Abbottabad. 34(Suppl 1): S987–S990. 2022. View Article : Google Scholar

Machado RB, Aguiar LMS and Silva JMC: Brazil: Plan for zero vegetation loss in the Cerrado. Nature. 615:2162023. View Article : Google Scholar : PubMed/NCBI

Dean M, Fojo T and Bates S: Tumour stem cells and drug resistance. Nat Rev Cancer. 5:275–284. 2005. View Article : Google Scholar : PubMed/NCBI

Brabletz T, Kalluri R, Nieto MA and Weinberg RA: EMT in cancer. Nat Rev Cancer. 18:128–134. 2018. View Article : Google Scholar : PubMed/NCBI

Belfiore A, Rapicavoli RV, Le Moli R, Lappano R, Morrione A, De Francesco EM and Vella V: IGF2: A role in metastasis and tumor evasion from immune surveillance? Biomedicines. 11:2292023. View Article : Google Scholar : PubMed/NCBI

Chhabra Y and Weeraratna AT: Fibroblasts in cancer: Unity in heterogeneity. Cell. 186:1580–1609. 2023. View Article : Google Scholar : PubMed/NCBI

Minchinton AI and Tannock IF: Drug penetration in solid tumours. Nat Rev Cancer. 6:583–592. 2006. View Article : Google Scholar : PubMed/NCBI

Wong L, Kumar A, Gabela-Zuniga B, Chua J, Singh G, Happe CL, Engler AJ, Fan Y and McCloskey KE: Substrate stiffness directs diverging vascular fates. Acta Biomater. 96:321–329. 2019. View Article : Google Scholar : PubMed/NCBI

Engler AJ, Sen S, Sweeney HL and Discher DE: Matrix elasticity directs stem cell lineage specification. Cell. 126:677–689. 2006. View Article : Google Scholar : PubMed/NCBI

Ruehle MA, Eastburn EA, LaBelle SA, Krishnan L, Weiss JA, Boerckel JD, Wood LB, Guldberg RE and Willett NJ: Extracellular matrix compression temporally regulates microvascular angiogenesis. Sci Adv. 6:eabb63512020. View Article : Google Scholar : PubMed/NCBI

Jing X, Yang F, Shao C, Wei K, Xie M, Shen H and Shu Y: Role of hypoxia in cancer therapy by regulating the tumor microenvironment. Mol Cancer. 18:1572019. View Article : Google Scholar : PubMed/NCBI

Alvarez R, Musteanu M, Garcia-Garcia E, Lopez-Casas PP, Megias D, Guerra C, Muñoz M, Quijano Y, Cubillo A, Rodriguez-Pascual J, et al: Stromal disrupting effects of nab-paclitaxel in pancreatic cancer. Br J Cancer. 109:926–933. 2013. View Article : Google Scholar : PubMed/NCBI

Kim H, Samuel S, Lopez-Casas P, Grizzle W, Hidalgo M, Kovar J, Oelschlager D, Zinn K, Warram J and Buchsbaum D: SPARC-independent delivery of nab-paclitaxel without depleting tumor stroma in patient-derived pancreatic cancer xenografts. Mol Cancer Ther. 15:680–688. 2016. View Article : Google Scholar : PubMed/NCBI

Zhang X, Zeng Y, Zhao L, Xu Q, Miao D and Yu F: Targeting hepatic stellate cell death to reverse hepatic fibrosis. Curr Drug Targets. 24:568–583. 2023. View Article : Google Scholar : PubMed/NCBI

Jin H, Lian N, Zhang F, Chen L, Chen Q, Lu C, Bian M, Shao J, Wu L and Zheng S: Activation of PPARγ/P53 signaling is required for curcumin to induce hepatic stellate cell senescence. Cell Death Dis. 7:e21892016. View Article : Google Scholar

Xia S, Liu Z, Cai J, Ren H, Li Q, Zhang H, Yue J, Zhou Q, Zhou T, Wang L, et al: Liver fibrosis therapy based on biomimetic nanoparticles which deplete activated hepatic stellate cells. J Control Release. 355:54–67. 2023. View Article : Google Scholar : PubMed/NCBI

Zi F, He J, He D, Li Y, Yang L and Cai Z: Fibroblast activation protein alpha in tumor microenvironment: Recent progression and implications (review). Mol Med Rep. 11:3203–3211. 2015. View Article : Google Scholar : PubMed/NCBI

Bughda R, Dimou P, D'Souza RR and Klampatsa A: Fibroblast activation protein (FAP)-targeted CAR-T cells: Launching an attack on tumor stroma. Immunotargets Ther. 10:313–323. 2021. View Article : Google Scholar : PubMed/NCBI

Claus C, Ferrara C, Xu W, Sam J, Lang S, Uhlenbrock F, Albrecht R, Herter S, Schlenker R, Hüsser T, et al: Tumor-targeted 4-1BB agonists for combination with T cell bispecific antibodies as off-the-shelf therapy. Sci Transl Med. 11:eaav59892019. View Article : Google Scholar : PubMed/NCBI

Melero I, Tanos T, Bustamante M, Sanmamed MF, Calvo E, Moreno I, Moreno V, Hernandez T, Martinez Garcia M, Rodriguez-Vida A, et al: A first-in-human study of the fibroblast activation protein-targeted, 4-1BB agonist RO7122290 in patients with advanced solid tumors. Sci Transl Med. 15:eabp92292023. View Article : Google Scholar : PubMed/NCBI

Ballal S, Yadav MP, Kramer V, Moon ES, Roesch F, Tripathi M, Mallick S, ArunRaj ST and Bal C: A theranostic approach of [⁶⁸Ga]Ga-DOTA.SA.FAPi PET/CT-guided [¹⁷⁷Lu]Lu-DOTA. SA.FAPi radionuclide therapy in an end-stage breast cancer patient: New frontier in targeted radionuclide therapy. Eur J Nucl Med Mol Imaging. 48:942–944. 2021. View Article : Google Scholar

Assadi M, Rekabpour SJ, Jafari E, Divband G, Nikkholgh B, Amini H, Kamali H, Ebrahimi S, Shakibazad N, Jokar N, et al: Feasibility and therapeutic potential of 177Lu-fibroblast activation protein inhibitor-46 for patients with relapsed or refractory cancers: A preliminary study. Clin Nucl Med. 46:e523–e530. 2021. View Article : Google Scholar : PubMed/NCBI

Baum RP, Schuchardt C, Singh A, Chantadisai M, Robiller FC, Zhang J, Mueller D, Eismant A, Almaguel F, Zboralski D, et al: Feasibility, biodistribution, and preliminary dosimetry in peptide-targeted radionuclide therapy of diverse adenocarcinomas using ¹⁷⁷Lu-FAP-2286: First-in-humans results. J Nucl Med. 63:415–423. 2022. View Article : Google Scholar :

Vallet SD and Ricard-Blum S: Lysyl oxidases: from enzyme activity to extracellular matrix cross-links. Essays Biochem. 63:349–364. 2019. View Article : Google Scholar : PubMed/NCBI

Granzow M, Schierwagen R, Klein S, Kowallick B, Huss S, Linhart M, Mazar IG, Görtzen J, Vogt A, Schildberg FA, et al: Angiotensin-II type 1 receptor-mediated Janus kinase 2 activation induces liver fibrosis. Hepatology. 60:334–348. 2014. View Article : Google Scholar : PubMed/NCBI

Takiguchi T, Takahashi-Yanaga F, Ishikane S, Tetsuo F, Hosoda H, Arioka M, Kitazono T and Sasaguri T: Angiotensin II promotes primary tumor growth and metastasis formation of murine TNBC 4T1 cells through the fibroblasts around cancer cells. Eur J Pharmacol. 909:1744152021. View Article : Google Scholar : PubMed/NCBI

Murphy JE, Wo JY, Ryan DP, Clark JW, Jiang W, Yeap BY, Drapek LC, Ly L, Baglini CV, Blaszkowsky LS, et al: Total neoadjuvant therapy with FOLFIRINOX in combination with losartan followed by chemoradiotherapy for locally advanced pancreatic cancer: A phase 2 clinical trial. JAMA Oncol. 5:1020–1027. 2019. View Article : Google Scholar : PubMed/NCBI

Wong KM, Horton KJ, Coveler AL, Hingorani SR and Harris WP: Targeting the tumor stroma: The biology and clinical development of pegylated recombinant human hyaluronidase (PEGPH20). Curr Oncol Rep. 19:472017. View Article : Google Scholar : PubMed/NCBI

Kudo D, Suto A and Hakamada K: The development of a novel therapeutic strategy to target hyaluronan in the extracellular matrix of pancreatic ductal adenocarcinoma. Int J Mol Sci. 18:6002017. View Article : Google Scholar : PubMed/NCBI

Ramanathan RK, McDonough SL, Philip PA, Hingorani SR, Lacy J, Kortmansky JS, Thumar J, Chiorean EG, Shields AF, Behl D, et al: Phase IB/II randomized study of FOLFIRINOX plus pegylated recombinant human hyaluronidase versus FOLFIRINOX alone in patients with metastatic pancreatic adenocarcinoma: SWOG S1313. J Clin Oncol. 37:1062–1069. 2019. View Article : Google Scholar : PubMed/NCBI

Van Cutsem E, Tempero MA, Sigal D, Oh DY, Fazio N, Macarulla T, Hitre E, Hammel P, Hendifar AE, Bates SE, et al: Randomized phase III trial of pegvorhyaluronidase alfa with nab-paclitaxel plus gemcitabine for patients with hyaluronan-high metastatic pancreatic adenocarcinoma. J Clin Oncol. 38:3185–3194. 2020. View Article : Google Scholar : PubMed/NCBI

Sakers A, De Siqueira MK, Seale P and Villanueva CJ: Adipose-tissue plasticity in health and disease. Cell. 185:419–446. 2022. View Article : Google Scholar : PubMed/NCBI

Koudelka S and Turánek J: Liposomal paclitaxel formulations. J Control Release. 163:322–334. 2012. View Article : Google Scholar : PubMed/NCBI

Shahriari K, Shen F, Worrede-Mahdi A, Liu Q, Gong Y, Garcia FU and Fatatis A: Cooperation among heterogeneous prostate cancer cells in the bone metastatic niche. Oncogene. 36:2846–2856. 2017. View Article : Google Scholar :

Nakamura Y, Kinoshita J, Yamaguchi T, Aoki T, Saito H, Hamabe-Horiike T, Harada S, Nomura S, Inaki N and Fushida S: Crosstalk between cancer-associated fibroblasts and immune cells in peritoneal metastasis: Inhibition in the migration of M2 macrophages and mast cells by Tranilast. Gastric Cancer. 25:515–526. 2022. View Article : Google Scholar : PubMed/NCBI

Suetsugu A, Osawa Y, Nagaki M, Saji S, Moriwaki H, Bouvet M and Hoffman RM: Imaging the recruitment of cancer-associated fibroblasts by liver-metastatic colon cancer. J Cell Biochem. 112:949–953. 2011. View Article : Google Scholar : PubMed/NCBI

Jung Y, Kim JK, Shiozawa Y, Wang J, Mishra A, Joseph J, Berry JE, McGee S, Lee E, Sun H, et al: Recruitment of mesenchymal stem cells into prostate tumours promotes metastasis. Nat Commun. 4:17952013. View Article : Google Scholar : PubMed/NCBI

Kidd S, Spaeth E, Watson K, Burks J, Lu H, Klopp A, Andreeff M and Marini FC: Origins of the tumor microenvironment: Quantitative assessment of adipose-derived and bone marrow-derived stroma. PLoS One. 7:e305632012. View Article : Google Scholar : PubMed/NCBI

Tang H, Chu Y, Huang Z, Cai J and Wang Z: The metastatic phenotype shift toward myofibroblast of adipose-derived mesenchymal stem cells promotes ovarian cancer progression. Carcinogenesis. 41:182–193. 2020. View Article : Google Scholar

Cho JA, Park H, Lim EH and Lee KW: Exosomes from breast cancer cells can convert adipose tissue-derived mesenchymal stem cells into myofibroblast-like cells. Int J Oncol. 40:130–138. 2012.

Karnoub AE, Dash AB, Vo AP, Sullivan A, Brooks MW, Bell GW, Richardson AL, Polyak K, Tubo R and Weinberg RA: Mesenchymal stem cells within tumour stroma promote breast cancer metastasis. Nature. 449:557–563. 2007. View Article : Google Scholar : PubMed/NCBI

Zhang J, Sun D, Fu Q, Cao Q, Zhang H and Zhang K: Bone mesenchymal stem cells differentiate into myofibroblasts in the tumor microenvironment. Oncol Lett. 12:644–650. 2016. View Article : Google Scholar : PubMed/NCBI

Bochet L, Lehuédé C, Dauvillier S, Wang YY, Dirat B, Laurent V, Dray C, Guiet R, Maridonneau-Parini I, Le Gonidec S, et al: Adipocyte-derived fibroblasts promote tumor progression and contribute to the desmoplastic reaction in breast cancer. Cancer Res. 73:5657–5668. 2013. View Article : Google Scholar : PubMed/NCBI

Jotzu C, Alt E, Welte G, Li J, Hennessy BT, Devarajan E, Krishnappa S, Pinilla S, Droll L and Song YH: Adipose tissue derived stem cells differentiate into carcinoma-associated fibroblast-like cells under the influence of tumor derived factors. Cell Oncol (Dordr). 34:55–67. 2011. View Article : Google Scholar : PubMed/NCBI

Baroni S, Romero-Cordoba S, Plantamura I, Dugo M, D'Ippolito E, Cataldo A, Cosentino G, Angeloni V, Rossini A, Daidone MG and Iorio MV: Exosome-mediated delivery of miR-9 induces cancer-associated fibroblast-like properties in human breast fibroblasts. Cell Death Dis. 7:e23122016. View Article : Google Scholar : PubMed/NCBI

Arina A, Idel C, Hyjek EM, Alegre ML, Wang Y, Bindokas VP, Weichselbaum RR and Schreiber H: Tumor-associated fibroblasts predominantly come from local and not circulating precursors. Proc Natl Acad Sci USA. 113:7551–7556. 2016. View Article : Google Scholar : PubMed/NCBI

Vicent S, Sayles LC, Vaka D, Khatri P, Gevaert O, Chen R, Zheng Y, Gillespie AK, Clarke N, Xu Y, et al: Cross-species functional analysis of cancer-associated fibroblasts identifies a critical role for CLCF1 and IL-6 in non-small cell lung cancer in vivo. Cancer Res. 72:5744–5756. 2012. View Article : Google Scholar : PubMed/NCBI

Nair N, Calle AS, Zahra MH, Prieto-Vila M, Oo AKK, Hurley L, Vaidyanath A, Seno A, Masuda J, Iwasaki Y, et al: A cancer stem cell model as the point of origin of cancer-associated fibroblasts in tumor microenvironment. Sci Rep. 7:68382017. View Article : Google Scholar : PubMed/NCBI

Sandoval P, Jiménez-Heffernan JA, Rynne-Vidal Á, Pérez-Lozano ML, Gilsanz Á, Ruiz-Carpio V, Reyes R, García-Bordas J, Stamatakis K, Dotor J, et al: Carcinoma-associated fibroblasts derive from mesothelial cells via mesothelial-to-mesenchymal transition in peritoneal metastasis. J Pathol. 231:517–531. 2013. View Article : Google Scholar : PubMed/NCBI

Zeisberg EM, Potenta S, Xie L, Zeisberg M and Kalluri R: Discovery of endothelial to mesenchymal transition as a source for carcinoma-associated fibroblasts. Cancer Res. 67:10123–10128. 2007. View Article : Google Scholar : PubMed/NCBI

Xin Y, Li K, Yang M and Tan Y: Fluid shear stress induces EMT of circulating tumor cells via JNK signaling in favor of their survival during hematogenous dissemination. Int J Mol Sci. 21:81152020. View Article : Google Scholar : PubMed/NCBI

Kan T, Wang W, Ip PP, Zhou S, Wong AS, Wang X and Yang M: Single-cell EMT-related transcriptional analysis revealed intra-cluster heterogeneity of tumor cell clusters in epithelial ovarian cancer ascites. Oncogene. 39:4227–4240. 2020. View Article : Google Scholar : PubMed/NCBI

Yoshimura Y, Suzuki D and Miyahara K: Measurement accuracy of fat and iron deposits in the liver using ¹H-MRS (HISTO). Nihon Hoshasen Gijutsu Gakkai Zasshi. 74:148–153. 2018.In Japanese. View Article : Google Scholar

Ringuette Goulet C, Bernard G, Tremblay S, Chabaud S, Bolduc S and Pouliot F: Exosomes induce fibroblast differentiation into cancer-associated fibroblasts through TGFbeta signaling. Mol Cancer Res. 16:1196–1204. 2018. View Article : Google Scholar : PubMed/NCBI

Zhang J, Fu L, Yasuda-Yoshihara N, Yonemura A, Wei F, Bu L, Hu X, Akiyama T, Kitamura F, Yasuda T, et al: IL-1β derived from mixed-polarized macrophages activates fibroblasts and synergistically forms a cancer-promoting microenvironment. Gastric Cancer. 26:187–202. 2023. View Article : Google Scholar

Wei LY, Lee JJ, Yeh CY, Yang CJ, Kok SH, Ko JY, Tsai FC and Chia JS: Reciprocal activation of cancer-associated fibroblasts and oral squamous carcinoma cells through CXCL1. Oral Oncol. 88:115–123. 2019. View Article : Google Scholar : PubMed/NCBI

Goulet CR, Champagne A, Bernard G, Vandal D, Chabaud S, Pouliot F and Bolduc S: Cancer-associated fibroblasts induce epithelial-mesenchymal transition of bladder cancer cells through paracrine IL-6 signalling. BMC Cancer. 19:1372019. View Article : Google Scholar : PubMed/NCBI

Scognamiglio I, Cocca L, Puoti I, Palma F, Ingenito F, Quintavalle C, Affinito A, Roscigno G, Nuzzo S, Chianese RV, et al: Exosomal microRNAs synergistically trigger stromal fibroblasts in breast cancer. Mol Ther Nucleic Acids. 28:17–31. 2022. View Article : Google Scholar : PubMed/NCBI

Qin X, Lu M, Li G, Zhou Y and Liu Z: Downregulation of tumor-derived exosomal miR-34c induces cancer-associated fibroblast activation to promote cholangiocarcinoma progress. Cancer Cell Int. 21:3732021. View Article : Google Scholar : PubMed/NCBI

Zhou X, Yan T, Huang C, Xu Z, Wang L, Jiang E, Wang H, Chen Y, Liu K, Shao Z and Shang Z: Melanoma cell-secreted exosomal miR-155-5p induce proangiogenic switch of cancer-associated fibroblasts via SOCS1/JAK2/STAT3 signaling pathway. J Exp Clin Cancer Res. 37:2422018. View Article : Google Scholar : PubMed/NCBI

Ye B, Duan Y, Zhou M, Wang Y, Lai Q, Yue K, Cao J, Wu Y, Wang X and Jing C: Hypoxic tumor-derived exosomal miR-21 induces cancer-associated fibroblast activation to promote head and neck squamous cell carcinoma metastasis. Cell Signal. 108:1107252023. View Article : Google Scholar : PubMed/NCBI

Xu Y, Kuai R, Chu YM, Zhou L, Zhang HQ and Li J: Hypoxia facilitates the proliferation of colorectal cancer cells by inducing cancer-associated fibroblast-derived IL6. Neoplasma. 68:1015–1022. 2021. View Article : Google Scholar : PubMed/NCBI

Butti R, Nimma R, Kundu G, Bulbule A, Kumar TVS, Gunasekaran VP, Tomar D, Kumar D, Mane A, Gill SS, et al: Tumor-derived osteopontin drives the resident fibroblast to myofibroblast differentiation through Twist1 to promote breast cancer progression. Oncogene. 40:2002–2017. 2021. View Article : Google Scholar : PubMed/NCBI

Calvo F, Ege N, Grande-Garcia A, Hooper S, Jenkins RP, Chaudhry SI, Harrington K, Williamson P, Moeendarbary E, Charras G and Sahai E: Mechanotransduction and YAP-dependent matrix remodelling is required for the generation and maintenance of cancer-associated fibroblasts. Nat Cell Biol. 15:637–646. 2013. View Article : Google Scholar : PubMed/NCBI

Foster CT, Gualdrini F and Treisman R: Mutual dependence of the MRTF-SRF and YAP-TEAD pathways in cancer-associated fibroblasts is indirect and mediated by cytoskeletal dynamics. Genes Dev. 31:2361–2375. 2017. View Article : Google Scholar

Cadamuro M, Nardo G, Indraccolo S, Dall'olmo L, Sambado L, Moserle L, Franceschet I, Colledan M, Massani M, Stecca T, et al: Platelet-derived growth factor-D and Rho GTPases regulate recruitment of cancer-associated fibroblasts in cholangiocarcinoma. Hepatology. 58:1042–1053. 2013. View Article : Google Scholar : PubMed/NCBI

Pietras K, Pahler J, Bergers G and Hanahan D: Functions of paracrine PDGF signaling in the proangiogenic tumor stroma revealed by pharmacological targeting. PLoS Med. 5:e192008. View Article : Google Scholar : PubMed/NCBI

Scherz-Shouval R, Santagata S, Mendillo ML, Sholl LM, Ben-Aharon I, Beck AH, Dias-Santagata D, Koeva M, Stemmer SM, Whitesell L and Lindquist S: The reprogramming of tumor stroma by HSF1 is a potent enabler of malignancy. Cell. 158:564–578. 2014. View Article : Google Scholar : PubMed/NCBI

Ferrari N, Ranftl R, Chicherova I, Slaven ND, Moeendarbary E, Farrugia AJ, Lam M, Semiannikova M, Westergaard MCW, Tchou J, et al: Dickkopf-3 links HSF1 and YAP/TAZ signalling to control aggressive behaviours in cancer-associated fibroblasts. Nat Commun. 10:1302019. View Article : Google Scholar : PubMed/NCBI

Guo Z, Zhang H, Fu Y, Kuang J, Zhao B, Zhang L, Lin J, Lin S, Wu D and Xie G: Cancer-associated fibroblasts induce growth and radioresistance of breast cancer cells through paracrine IL-6. Cell Death Discov. 9:62023. View Article : Google Scholar : PubMed/NCBI

Çermik TF, Ergül N, Yılmaz B and Mercanoğlu G: Tumor imaging with 68Ga-DOTA-FAPI-04 PET/CT: Comparison with 18F-FDG PET/CT in 22 different cancer types. Clin Nucl Med. 47:e333–e339. 2022. View Article : Google Scholar : PubMed/NCBI

Pang Y, Zhao L, Meng T, Xu W, Lin Q, Wu H, Zhang J, Chen X, Sun L and Chen H: PET imaging of fibroblast activation protein in various types of cancer using ⁶⁸Ga-FAP-2286: comparison with ¹⁸F-FDG and ⁶⁸Ga-FAPI-46 in a single-center, prospective study. J Nucl Med. 64:386–394. 2023. View Article : Google Scholar :

Hosein AN, Huang H, Wang Z, Parmar K, Du W, Huang J, Maitra A, Olson E, Verma U and Brekken RA: Cellular heterogeneity during mouse pancreatic ductal adenocarcinoma progression at single-cell resolution. JCI Insight. 5:e1292122019. View Article : Google Scholar : PubMed/NCBI

Neuzillet C, Tijeras-Raballand A, Ragulan C, Cros J, Patil Y, Martinet M, Erkan M, Kleeff J, Wilson J, Apte M, et al: Inter- and intra-tumoural heterogeneity in cancer-associated fibroblasts of human pancreatic ductal adenocarcinoma. J Pathol. 248:51–65. 2019. View Article : Google Scholar :

Lin W, Noel P, Borazanci EH, Lee J, Amini A, Han IW, Heo JS, Jameson GS, Fraser C, Steinbach M, et al: Single-cell transcriptome analysis of tumor and stromal compartments of pancreatic ductal adenocarcinoma primary tumors and metastatic lesions. Genome Med. 12:802020. View Article : Google Scholar : PubMed/NCBI

Sebastian A, Hum NR, Martin KA, Gilmore SF, Peran I, Byers SW, Wheeler EK, Coleman MA and Loots GG: Single-cell transcriptomic analysis of tumor-derived fibroblasts and normal tissue-resident fibroblasts reveals fibroblast heterogeneity in breast cancer. Cancers (Basel). 12:13072020. View Article : Google Scholar : PubMed/NCBI

Li H, Courtois ET, Sengupta D, Tan Y, Chen KH, Goh JJL, Kong SL, Chua C, Hon LK, Tan WS, et al: Reference component analysis of single-cell transcriptomes elucidates cellular heterogeneity in human colorectal tumors. Nat Genet. 49:708–718. 2017. View Article : Google Scholar : PubMed/NCBI

Peng Z, Ye M, Ding H, Feng Z and Hu K: Spatial transcriptomics atlas reveals the crosstalk between cancer-associated fibroblasts and tumor microenvironment components in colorectal cancer. J Transl Med. 20:3022022. View Article : Google Scholar : PubMed/NCBI

Lambrechts D, Wauters E, Boeckx B, Aibar S, Nittner D, Burton O, Bassez A, Decaluwé H, Pircher A, Van den Eynde K, et al: Phenotype molding of stromal cells in the lung tumor microenvironment. Nat Med. 24:1277–1289. 2018. View Article : Google Scholar : PubMed/NCBI

Hornburg M, Desbois M, Lu S, Guan Y, Lo AA, Kaufman S, Elrod A, Lotstein A, DesRochers TM, Munoz-Rodriguez JL, et al: Single-cell dissection of cellular components and interactions shaping the tumor immune phenotypes in ovarian cancer. Cancer Cell. 39:928–944.e6. 2021. View Article : Google Scholar : PubMed/NCBI

Izar B, Tirosh I, Stover EH, Wakiro I, Cuoco MS, Alter I, Rodman C, Leeson R, Su MJ, Shah P, et al: A single-cell landscape of high-grade serous ovarian cancer. Nat Med. 26:1271–1279. 2020. View Article : Google Scholar : PubMed/NCBI

Zhang M, Yang H, Wan L, Wang Z, Wang H, Ge C, Liu Y, Hao Y, Zhang D, Shi G, et al: Single-cell transcriptomic architecture and intercellular crosstalk of human intrahepatic cholangiocarcinoma. J Hepatol. 73:1118–1130. 2020. View Article : Google Scholar : PubMed/NCBI

Davidson S, Efremova M, Riedel A, Mahata B, Pramanik J, Huuhtanen J, Kar G, Vento-Tormo R, Hagai T, Chen X, et al: Single-cell RNA sequencing reveals a dynamic stromal niche that supports tumor growth. Cell Rep. 31:1076282020. View Article : Google Scholar : PubMed/NCBI

Chen Z, Zhou L, Liu L, Hou Y, Xiong M, Yang Y, Hu J and Chen K: Single-cell RNA sequencing highlights the role of inflammatory cancer-associated fibroblasts in bladder urothelial carcinoma. Nat Commun. 11:50772020. View Article : Google Scholar : PubMed/NCBI

Kürten CHL, Kulkarni A, Cillo AR, Santos PM, Roble AK, Onkar S, Reeder C, Lang S, Chen X, Duvvuri U, et al: Investigating immune and non-immune cell interactions in head and neck tumors by single-cell RNA sequencing. Nat Commun. 12:73382021. View Article : Google Scholar : PubMed/NCBI