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Nuclear miRNAs as transcriptional regulators in processes related to various cancers (Review)

  • Authors:
    • Ziqiang Wang
    • Yu Zhang
    • Kun Li
  • View Affiliations / Copyright

    Affiliations: Department of Nuclear Medicine, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Jinan, Shandong 250014, P.R. China, Biomedical Sciences College & Shandong Medicinal Biotechnology Centre, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong 250117, P.R. China
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 4.0].
  • Article Number: 56
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    Published online on: April 9, 2024
       https://doi.org/10.3892/ijo.2024.5644
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Abstract

MicroRNAs (miRNAs) are noncoding small nucleic acids that contain ~22 nucleotides and are considered to promote the degradation or inhibit the translation of mRNA by targeting its 3'‑untranslated region. However, growing evidence has revealed that nuclear miRNAs, combined with gene promoters or enhancers, are able to directly mediate gene transcription. These miRNAs exert a critical influence on cancer progression by affecting cell growth, migration and invasion. In this review, the direct regulation of gene expression by nuclear miRNAs at the transcriptional level was discussed and summarized, and their mechanisms of action in cancers were highlighted with reference to the various body systems.
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Copy and paste a formatted citation
Spandidos Publications style
Wang Z, Zhang Y and Li K: Nuclear miRNAs as transcriptional regulators in processes related to various cancers (Review). Int J Oncol 64: 56, 2024.
APA
Wang, Z., Zhang, Y., & Li, K. (2024). Nuclear miRNAs as transcriptional regulators in processes related to various cancers (Review). International Journal of Oncology, 64, 56. https://doi.org/10.3892/ijo.2024.5644
MLA
Wang, Z., Zhang, Y., Li, K."Nuclear miRNAs as transcriptional regulators in processes related to various cancers (Review)". International Journal of Oncology 64.5 (2024): 56.
Chicago
Wang, Z., Zhang, Y., Li, K."Nuclear miRNAs as transcriptional regulators in processes related to various cancers (Review)". International Journal of Oncology 64, no. 5 (2024): 56. https://doi.org/10.3892/ijo.2024.5644
Copy and paste a formatted citation
x
Spandidos Publications style
Wang Z, Zhang Y and Li K: Nuclear miRNAs as transcriptional regulators in processes related to various cancers (Review). Int J Oncol 64: 56, 2024.
APA
Wang, Z., Zhang, Y., & Li, K. (2024). Nuclear miRNAs as transcriptional regulators in processes related to various cancers (Review). International Journal of Oncology, 64, 56. https://doi.org/10.3892/ijo.2024.5644
MLA
Wang, Z., Zhang, Y., Li, K."Nuclear miRNAs as transcriptional regulators in processes related to various cancers (Review)". International Journal of Oncology 64.5 (2024): 56.
Chicago
Wang, Z., Zhang, Y., Li, K."Nuclear miRNAs as transcriptional regulators in processes related to various cancers (Review)". International Journal of Oncology 64, no. 5 (2024): 56. https://doi.org/10.3892/ijo.2024.5644
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