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Review Special Issue Open Access

Decoding long non‑coding RNAs: Friends and foes in cancer development (Review)

This article is part of the special Issue: Long non-coding RNAs and cancer: implications for diagnosis, prognosis and treatment
  • Authors:
    • Hequn Song
    • Joseph Adu-Amankwaah
    • Qizhong Zhao
    • Dongqi Yang
    • Kuntao Liu
    • Aisha Bushi
    • Jinming Zhao
    • Jinxiang Yuan
    • Rubin Tan
  • View Affiliations / Copyright

    Affiliations: First Clinical Medical School, Xuzhou Medical University, Xuzhou, Jiangsu 221004, P.R. China, Department of Physiology, Basic Medical School, Xuzhou Medical University, Xuzhou, Jiangsu 221004, P.R. China, Department of Emergency, The First Hospital of China Medical University, Shenyang, Liaoning 110122, P.R. China, School of Life Science, Xuzhou Medical University, Xuzhou, Jiangsu 22100, P.R. China, School of International Education, Xuzhou Medical University, Xuzhou, Jiangsu 221004, P.R. China, Department of Pathology, College of Basic Medical Sciences, China Medical University, Shenyang, Liaoning 110122, P.R. China, Lin He Academician Workstation of New Medicine and Clinical Translation, Jining Medical University, Jining, Shandong 272067, P.R. China
    Copyright: © Song et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 61
    |
    Published online on: May 1, 2024
       https://doi.org/10.3892/ijo.2024.5649
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Abstract

Cancer remains a formidable adversary, challenging medical advancements with its dismal prognosis, low cure rates and high mortality rates. Within this intricate landscape, long non‑coding RNAs (lncRNAs) emerge as pivotal players, orchestrating proliferation and migration of cancer cells. Harnessing the potential of lncRNAs as therapeutic targets and prognostic markers holds immense promise. The present comprehensive review delved into the molecular mechanisms underlying the involvement of lncRNAs in the onset and progression of the top five types of cancer. By meticulously examining lncRNAs across diverse types of cancer, it also uncovered their distinctive roles, highlighting their exclusive oncogenic effects or tumor suppressor properties. Notably, certain lncRNAs demonstrate diverse functions across different cancers, confounding the conventional understanding of their roles. Furthermore, the present study identified lncRNAs exhibiting aberrant expression patterns in numerous types of cancer, presenting them as potential indicators for cancer screening and diagnosis. Conversely, a subset of lncRNAs manifests tissue‑specific expression, hinting at their specialized nature and untapped significance in diagnosing and treating specific types of cancer. The present comprehensive review not only shed light on the intricate network of lncRNAs but also paved the way for further research and clinical applications. The unraveled molecular mechanisms offer a promising avenue for targeted therapeutics and personalized medicine, combating cancer proliferation, invasion and metastasis.
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Song H, Adu-Amankwaah J, Zhao Q, Yang D, Liu K, Bushi A, Zhao J, Yuan J and Tan R: Decoding long non‑coding RNAs: Friends and foes in cancer development (Review). Int J Oncol 64: 61, 2024.
APA
Song, H., Adu-Amankwaah, J., Zhao, Q., Yang, D., Liu, K., Bushi, A. ... Tan, R. (2024). Decoding long non‑coding RNAs: Friends and foes in cancer development (Review). International Journal of Oncology, 64, 61. https://doi.org/10.3892/ijo.2024.5649
MLA
Song, H., Adu-Amankwaah, J., Zhao, Q., Yang, D., Liu, K., Bushi, A., Zhao, J., Yuan, J., Tan, R."Decoding long non‑coding RNAs: Friends and foes in cancer development (Review)". International Journal of Oncology 64.6 (2024): 61.
Chicago
Song, H., Adu-Amankwaah, J., Zhao, Q., Yang, D., Liu, K., Bushi, A., Zhao, J., Yuan, J., Tan, R."Decoding long non‑coding RNAs: Friends and foes in cancer development (Review)". International Journal of Oncology 64, no. 6 (2024): 61. https://doi.org/10.3892/ijo.2024.5649
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Spandidos Publications style
Song H, Adu-Amankwaah J, Zhao Q, Yang D, Liu K, Bushi A, Zhao J, Yuan J and Tan R: Decoding long non‑coding RNAs: Friends and foes in cancer development (Review). Int J Oncol 64: 61, 2024.
APA
Song, H., Adu-Amankwaah, J., Zhao, Q., Yang, D., Liu, K., Bushi, A. ... Tan, R. (2024). Decoding long non‑coding RNAs: Friends and foes in cancer development (Review). International Journal of Oncology, 64, 61. https://doi.org/10.3892/ijo.2024.5649
MLA
Song, H., Adu-Amankwaah, J., Zhao, Q., Yang, D., Liu, K., Bushi, A., Zhao, J., Yuan, J., Tan, R."Decoding long non‑coding RNAs: Friends and foes in cancer development (Review)". International Journal of Oncology 64.6 (2024): 61.
Chicago
Song, H., Adu-Amankwaah, J., Zhao, Q., Yang, D., Liu, K., Bushi, A., Zhao, J., Yuan, J., Tan, R."Decoding long non‑coding RNAs: Friends and foes in cancer development (Review)". International Journal of Oncology 64, no. 6 (2024): 61. https://doi.org/10.3892/ijo.2024.5649
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