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Ageing microenvironment mediates lymphocyte carcinogenesis and lymphoma drug resistance: From mechanisms to clinical therapy (Review)

  • Authors:
    • Yue Zhang
    • Jingwen Chu
    • Qi Hou
    • Siyu Qian
    • Zeyuan Wang
    • Qing Yang
    • Wenting Song
    • Ling Dong
    • Zhuangzhuang Shi
    • Yuyang Gao
    • Miaomiao Meng
    • Mingzhi Zhang
    • Xudong Zhang
    • Qingjiang Chen
  • View Affiliations / Copyright

    Affiliations: Department of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, P.R. China, Department of Oncology, The Third Affiliated Hospital of Xinxiang Medical University, Xinxiang, Henan 453003, P.R. China
    Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 65
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    Published online on: May 10, 2024
       https://doi.org/10.3892/ijo.2024.5653
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Abstract

Cellular senescence has a complex role in lymphocyte carcinogenesis and drug resistance of lymphomas. Senescent lymphoma cells combine with immunocytes to create an ageing environment that can be reprogrammed with a senescence‑associated secretory phenotype, which gradually promotes therapeutic resistance. Certain signalling pathways, such as the NF‑κB, Wnt and PI3K/AKT/mTOR pathways, regulate the tumour ageing microenvironment and induce the proliferation and progression of lymphoma cells. Therefore, targeting senescence‑related enzymes or their signal transduction pathways may overcome radiotherapy or chemotherapy resistance and enhance the efficacy of relapsed/refractory lymphoma treatments. Mechanisms underlying drug resistance in lymphomas are complex. The ageing microenvironment is a novel factor that contributes to drug resistance in lymphomas. In terms of clinical translation, some senolytics have been used in clinical trials on patients with relapsed or refractory lymphoma. Combining immunotherapy with epigenetic drugs may achieve better therapeutic effects; however, senescent cells exhibit considerable heterogeneity and lymphoma has several subtypes. Extensive research is necessary to achieve the practical application of senolytics in relapsed or refractory lymphomas. This review summarises the mechanisms of senescence‑associated drug resistance in lymphoma, as well as emerging strategies using senolytics, to overcome therapeutic resistance in lymphoma.
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Copy and paste a formatted citation
Spandidos Publications style
Zhang Y, Chu J, Hou Q, Qian S, Wang Z, Yang Q, Song W, Dong L, Shi Z, Gao Y, Gao Y, et al: Ageing microenvironment mediates lymphocyte carcinogenesis and lymphoma drug resistance: From mechanisms to clinical therapy (Review). Int J Oncol 64: 65, 2024.
APA
Zhang, Y., Chu, J., Hou, Q., Qian, S., Wang, Z., Yang, Q. ... Chen, Q. (2024). Ageing microenvironment mediates lymphocyte carcinogenesis and lymphoma drug resistance: From mechanisms to clinical therapy (Review). International Journal of Oncology, 64, 65. https://doi.org/10.3892/ijo.2024.5653
MLA
Zhang, Y., Chu, J., Hou, Q., Qian, S., Wang, Z., Yang, Q., Song, W., Dong, L., Shi, Z., Gao, Y., Meng, M., Zhang, M., Zhang, X., Chen, Q."Ageing microenvironment mediates lymphocyte carcinogenesis and lymphoma drug resistance: From mechanisms to clinical therapy (Review)". International Journal of Oncology 64.6 (2024): 65.
Chicago
Zhang, Y., Chu, J., Hou, Q., Qian, S., Wang, Z., Yang, Q., Song, W., Dong, L., Shi, Z., Gao, Y., Meng, M., Zhang, M., Zhang, X., Chen, Q."Ageing microenvironment mediates lymphocyte carcinogenesis and lymphoma drug resistance: From mechanisms to clinical therapy (Review)". International Journal of Oncology 64, no. 6 (2024): 65. https://doi.org/10.3892/ijo.2024.5653
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang Y, Chu J, Hou Q, Qian S, Wang Z, Yang Q, Song W, Dong L, Shi Z, Gao Y, Gao Y, et al: Ageing microenvironment mediates lymphocyte carcinogenesis and lymphoma drug resistance: From mechanisms to clinical therapy (Review). Int J Oncol 64: 65, 2024.
APA
Zhang, Y., Chu, J., Hou, Q., Qian, S., Wang, Z., Yang, Q. ... Chen, Q. (2024). Ageing microenvironment mediates lymphocyte carcinogenesis and lymphoma drug resistance: From mechanisms to clinical therapy (Review). International Journal of Oncology, 64, 65. https://doi.org/10.3892/ijo.2024.5653
MLA
Zhang, Y., Chu, J., Hou, Q., Qian, S., Wang, Z., Yang, Q., Song, W., Dong, L., Shi, Z., Gao, Y., Meng, M., Zhang, M., Zhang, X., Chen, Q."Ageing microenvironment mediates lymphocyte carcinogenesis and lymphoma drug resistance: From mechanisms to clinical therapy (Review)". International Journal of Oncology 64.6 (2024): 65.
Chicago
Zhang, Y., Chu, J., Hou, Q., Qian, S., Wang, Z., Yang, Q., Song, W., Dong, L., Shi, Z., Gao, Y., Meng, M., Zhang, M., Zhang, X., Chen, Q."Ageing microenvironment mediates lymphocyte carcinogenesis and lymphoma drug resistance: From mechanisms to clinical therapy (Review)". International Journal of Oncology 64, no. 6 (2024): 65. https://doi.org/10.3892/ijo.2024.5653
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