Open Access

Investigating the molecular mechanisms of microRNA‑409‑3p in tumor progression: Towards targeted therapeutics (Review)

  • Authors:
    • Wenjie Xie
    • Zhichao Wang
    • Junke Wang
    • Xiu Wang
    • Hongzai Guan
  • View Affiliations

  • Published online on: May 16, 2024     https://doi.org/10.3892/ijo.2024.5655
  • Article Number: 67
  • Copyright: © Xie et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 4.0].

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Abstract

MicroRNAs (miRNAs) are a group of non‑coding RNAs that exert master regulatory functions in post‑­transcriptional gene expression. Accumulating evidence shows that miRNAs can either promote or suppress tumorigenesis by regulating different target genes or pathways and may be involved in the occurrence of carcinoma. miR‑409‑3p is dysregulated in a variety of malignant cancers. It plays a fundamental role in numerous cellular biological processes, such as cell proliferation, apoptosis, migration, invasion, autophagy, angiogenesis and glycolysis. In addition, studies have shown that miR‑409‑3p is expected to become a non‑invasive biomarker. Identifying the molecular mechanisms underlying miR‑409‑3p‑mediated tumor progression will help investigate miR‑409‑3p‑based targeted therapy for human cancers. The present review comprehensively summarized the recently published literature on miR‑409‑3p, with a focus on the regulation and function of miR‑409‑3p in various types of cancer, and discussed the clinical implications of miR‑409‑3p, providing new insight for the diagnosis and treatment of cancers.
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July-2024
Volume 65 Issue 1

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Copy and paste a formatted citation
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Spandidos Publications style
Xie W, Wang Z, Wang J, Wang X and Guan H: Investigating the molecular mechanisms of microRNA‑409‑3p in tumor progression: Towards targeted therapeutics (Review). Int J Oncol 65: 67, 2024.
APA
Xie, W., Wang, Z., Wang, J., Wang, X., & Guan, H. (2024). Investigating the molecular mechanisms of microRNA‑409‑3p in tumor progression: Towards targeted therapeutics (Review). International Journal of Oncology, 65, 67. https://doi.org/10.3892/ijo.2024.5655
MLA
Xie, W., Wang, Z., Wang, J., Wang, X., Guan, H."Investigating the molecular mechanisms of microRNA‑409‑3p in tumor progression: Towards targeted therapeutics (Review)". International Journal of Oncology 65.1 (2024): 67.
Chicago
Xie, W., Wang, Z., Wang, J., Wang, X., Guan, H."Investigating the molecular mechanisms of microRNA‑409‑3p in tumor progression: Towards targeted therapeutics (Review)". International Journal of Oncology 65, no. 1 (2024): 67. https://doi.org/10.3892/ijo.2024.5655