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Glutathione‑degrading enzymes in the complex landscape of tumors (Review)

  • This article is part of the special Issue: Going to the discovery of new biomarkers in cancer
  • Authors:
    • Tianyi Zhang
    • Chongjie Yao
    • Xu Zhou
    • Shimin Liu
    • Li Qi
    • Shiguo Zhu
    • Chen Zhao
    • Dan Hu
    • Weidong Shen
  • View Affiliations

  • Published online on: June 3, 2024     https://doi.org/10.3892/ijo.2024.5660
  • Article Number: 72
  • Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Glutathione (GSH)‑degrading enzymes are essential for starting the first stages of GSH degradation. These enzymes include extracellular γ‑glutamyl transpeptidase (GGT) and intracellular GSH‑specific γ‑glutamylcyclotransferase 1 (ChaC1) and 2. These enzymes are essential for cellular activities, such as immune response, differentiation, proliferation, homeostasis regulation and programmed cell death. Tumor tissue frequently exhibits abnormal expression of GSH‑degrading enzymes, which has a key impact on the development and spread of malignancies. The present review summarizes gene and protein structure, catalytic activity and regulation of GSH‑degrading enzymes, their vital roles in tumor development (including regulation of oxidative and endoplasmic reticulum stress, control of programmed cell death, promotion of inflammation and tumorigenesis and modulation of drug resistance in tumor cells) and potential role as diagnostic biomarkers and therapeutic targets.
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July-2024
Volume 65 Issue 1

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Copy and paste a formatted citation
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Spandidos Publications style
Zhang T, Yao C, Zhou X, Liu S, Qi L, Zhu S, Zhao C, Hu D and Shen W: Glutathione‑degrading enzymes in the complex landscape of tumors (Review). Int J Oncol 65: 72, 2024.
APA
Zhang, T., Yao, C., Zhou, X., Liu, S., Qi, L., Zhu, S. ... Shen, W. (2024). Glutathione‑degrading enzymes in the complex landscape of tumors (Review). International Journal of Oncology, 65, 72. https://doi.org/10.3892/ijo.2024.5660
MLA
Zhang, T., Yao, C., Zhou, X., Liu, S., Qi, L., Zhu, S., Zhao, C., Hu, D., Shen, W."Glutathione‑degrading enzymes in the complex landscape of tumors (Review)". International Journal of Oncology 65.1 (2024): 72.
Chicago
Zhang, T., Yao, C., Zhou, X., Liu, S., Qi, L., Zhu, S., Zhao, C., Hu, D., Shen, W."Glutathione‑degrading enzymes in the complex landscape of tumors (Review)". International Journal of Oncology 65, no. 1 (2024): 72. https://doi.org/10.3892/ijo.2024.5660