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Review Special Issue Open Access

Glutathione‑degrading enzymes in the complex landscape of tumors (Review)

This article is part of the special Issue: Going to the discovery of new biomarkers in cancer
  • Authors:
    • Tianyi Zhang
    • Chongjie Yao
    • Xu Zhou
    • Shimin Liu
    • Li Qi
    • Shiguo Zhu
    • Chen Zhao
    • Dan Hu
    • Weidong Shen
  • View Affiliations / Copyright

    Affiliations: Department of Acupuncture, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201203, P.R. China, School of Acupuncture‑moxibustion and Tuina, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, P.R. China, Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, P.R. China, School of Basic Medical Sciences, Center for Traditional Chinese Medicine and Immunology Research, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, P.R. China
    Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 72
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    Published online on: June 3, 2024
       https://doi.org/10.3892/ijo.2024.5660
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Abstract

Glutathione (GSH)‑degrading enzymes are essential for starting the first stages of GSH degradation. These enzymes include extracellular γ‑glutamyl transpeptidase (GGT) and intracellular GSH‑specific γ‑glutamylcyclotransferase 1 (ChaC1) and 2. These enzymes are essential for cellular activities, such as immune response, differentiation, proliferation, homeostasis regulation and programmed cell death. Tumor tissue frequently exhibits abnormal expression of GSH‑degrading enzymes, which has a key impact on the development and spread of malignancies. The present review summarizes gene and protein structure, catalytic activity and regulation of GSH‑degrading enzymes, their vital roles in tumor development (including regulation of oxidative and endoplasmic reticulum stress, control of programmed cell death, promotion of inflammation and tumorigenesis and modulation of drug resistance in tumor cells) and potential role as diagnostic biomarkers and therapeutic targets.
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Copy and paste a formatted citation
Spandidos Publications style
Zhang T, Yao C, Zhou X, Liu S, Qi L, Zhu S, Zhao C, Hu D and Shen W: Glutathione‑degrading enzymes in the complex landscape of tumors (Review). Int J Oncol 65: 72, 2024.
APA
Zhang, T., Yao, C., Zhou, X., Liu, S., Qi, L., Zhu, S. ... Shen, W. (2024). Glutathione‑degrading enzymes in the complex landscape of tumors (Review). International Journal of Oncology, 65, 72. https://doi.org/10.3892/ijo.2024.5660
MLA
Zhang, T., Yao, C., Zhou, X., Liu, S., Qi, L., Zhu, S., Zhao, C., Hu, D., Shen, W."Glutathione‑degrading enzymes in the complex landscape of tumors (Review)". International Journal of Oncology 65.1 (2024): 72.
Chicago
Zhang, T., Yao, C., Zhou, X., Liu, S., Qi, L., Zhu, S., Zhao, C., Hu, D., Shen, W."Glutathione‑degrading enzymes in the complex landscape of tumors (Review)". International Journal of Oncology 65, no. 1 (2024): 72. https://doi.org/10.3892/ijo.2024.5660
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang T, Yao C, Zhou X, Liu S, Qi L, Zhu S, Zhao C, Hu D and Shen W: Glutathione‑degrading enzymes in the complex landscape of tumors (Review). Int J Oncol 65: 72, 2024.
APA
Zhang, T., Yao, C., Zhou, X., Liu, S., Qi, L., Zhu, S. ... Shen, W. (2024). Glutathione‑degrading enzymes in the complex landscape of tumors (Review). International Journal of Oncology, 65, 72. https://doi.org/10.3892/ijo.2024.5660
MLA
Zhang, T., Yao, C., Zhou, X., Liu, S., Qi, L., Zhu, S., Zhao, C., Hu, D., Shen, W."Glutathione‑degrading enzymes in the complex landscape of tumors (Review)". International Journal of Oncology 65.1 (2024): 72.
Chicago
Zhang, T., Yao, C., Zhou, X., Liu, S., Qi, L., Zhu, S., Zhao, C., Hu, D., Shen, W."Glutathione‑degrading enzymes in the complex landscape of tumors (Review)". International Journal of Oncology 65, no. 1 (2024): 72. https://doi.org/10.3892/ijo.2024.5660
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