Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
International Journal of Oncology
Join Editorial Board Propose a Special Issue
Print ISSN: 1019-6439 Online ISSN: 1791-2423
Journal Cover
July-2024 Volume 65 Issue 1

Full Size Image

Cover Legend PDF

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
July-2024 Volume 65 Issue 1

Full Size Image

Cover Legend PDF

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML

  • Supplementary Files
    • Supplementary_Data1.pdf
    • Supplementary_Data2.pdf
Article Open Access

Significance of signal recognition particle 9 nuclear translocation: Implications for pancreatic cancer prognosis and functionality

  • Authors:
    • Hiromichi Sato
    • Sikun Meng
    • Kazuki Sasaki
    • Shogo Kobayashi
    • Kansuke Kido
    • Yoshiko Tsuji
    • Yasuko Arao
    • Yoshiko Saito
    • Yoshifumi Iwagami
    • Daisaku Yamada
    • Yoshito Tomimaru
    • Takehiro Noda
    • Hidenori Takahashi
    • Daisuke Motooka
    • Shizuka Uchida
    • Ken Ofusa
    • Taroh Satoh
    • Yuichiro Doki
    • Hidetoshi Eguchi
    • Tomoaki Hara
    • Hideshi Ishii
  • View Affiliations / Copyright

    Affiliations: Department of Medical Data Science, Center of Medical Innovation and Translational Research, Osaka University Graduate School of Medicine, Osaka 565‑0871, Japan, Department of Gastroenterological Surgery, Osaka University Graduate School of Medicine, Osaka 565‑0871, Japan, Department of Pathology, Osaka University Graduate School of Medicine, Osaka 565‑0871, Japan, Genome Information Research Center, Research Institute for Microbial Diseases, Osaka University, Osaka 565‑0871, Japan, Center for RNA Medicine, Department of Clinical Medicine, Aalborg University, DK‑2450 Copenhagen, Denmark
    Copyright: © Sato et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 74
    |
    Published online on: June 6, 2024
       https://doi.org/10.3892/ijo.2024.5662
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Signal recognition particles (SRPs) are essential for regulating intracellular protein transport and secretion. Patients with tumors with high SRP9 expression tend to have a poorer overall survival. However, to the best of our knowledge, no reports have described the relationship between SRP9 localization and prognosis in pancreatic cancer. Thus, the present study aimed to investigate this relationship. Immunohistochemical staining for SRP9 using excised specimens from pancreatic cancer surgery cases without preoperative chemotherapy or radiotherapy showed that SRP9 was preferentially expressed in the nucleus of the cancerous regions in some cases, which was hardly detected in other cases, indicating that SRP9 was transported to the nucleus in the former cases. To compare the prognosis of patients with SRP9 nuclear translocation, patients were divided into two groups: Those with a nuclear translocation rate of >50% and those with a nuclear translocation rate of ≤50%. The nuclear translocation rate of >50% group had a significantly better recurrence‑free survival than the nuclear translocation rate of ≤50% group (P=0.037). Subsequent in vitro experiments were conducted; notably, the nuclear translocation rate of SRP9 was reduced under amino acid‑deficient conditions, suggesting that multiple factors are involved in this phenomenon. To further study the function of SRP9 nuclear translocation, in vitro experiments were performed by introducing SRP9 splicing variants (v1 and v2) and their deletion mutants lacking C‑terminal regions into MiaPaCa pancreatic cancer cells. The results demonstrated that both splicing variants showed nuclear translocation regardless of the C‑terminal deletions, suggesting the role of the N‑terminal regions. Given that SRP9 is an RNA‑binding protein, the study of RNA immunoprecipitation revealed that signaling pathways involved in cancer progression and protein translation were downregulated in nuclear‑translocated v1 and v2. Undoubtedly, further studies of the nuclear translocation of SRP9 will open an avenue to optimize the precise evaluation and therapeutic control of pancreatic cancer.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1 

Kellogg MK, Tikhonova EB and Karamyshev AL: Signal recognition particle in human diseases. Front Genet. 13:8980832022. View Article : Google Scholar : PubMed/NCBI

2 

Erdogan G, Trabulus DC, Talu CK and Guven M: Investigation of SRP9 protein expression in breast cancer. Mol Biol Rep. 49:531–537. 2022. View Article : Google Scholar

3 

Rho JH, Qin S, Wang JY and Roehrl MH: Proteomic expression analysis of surgical human colorectal cancer tissues: Up-regulation of PSB7, PRDX1, and SRP9 and hypoxic adaptation in cancer. J Proteome Res. 7:2959–2972. 2008. View Article : Google Scholar : PubMed/NCBI

4 

Zhang M, Peng Y, Yang Z, Zhang H, Xu C, Liu L, Zhao Q, Wu J, Wang H and Liu J: DAB2IP down-regulates HSP90AA1 to inhibit the malignant biological behaviors of colorectal cancer. BMC Cancer. 22:5612022. View Article : Google Scholar : PubMed/NCBI

5 

Hessel EV, de Wit M, Wolterink-Donselaar IG, Karst H, de Graaff E, van Lith HA, de Bruijn E, de Sonnaville S, Verbeek NE, Lindhout D, et al: Identification of Srp9 as a febrile seizure susceptibility gene. Ann Clin Transl Neurol. 1:239–250. 2014. View Article : Google Scholar

6 

Bovia F, Fornallaz M, Leffers H and Strub K: The SRP9/14 subunit of the signal recognition particle (SRP) is present in more than 20-fold excess over SRP in primate cells and exists primarily free but also in complex with small cytoplasmic Alu RNAs. Mol Biol Cell. 6:471–484. 1995. View Article : Google Scholar : PubMed/NCBI

7 

Berger A, Ivanova E, Gareau C, Scherrer A, Mazroui R and Strub K: Direct binding of the Alu binding protein dimer SRP9/14 to 40S ribosomal subunits promotes stress granule formation and is regulated by Alu RNA. Nucleic Acids Res. 42:11203–11217. 2014. View Article : Google Scholar : PubMed/NCBI

8 

Nabet BY, Qiu Y, Shabason JE, Wu TJ, Yoon T, Kim BC, Benci JL, DeMichele AM, Tchou J, Marcotrigiano J and Minn AJ: Exosome RNA unshielding couples stromal activation to pattern recognition receptor signaling in cancer. Cell. 170:352–366 e13. 2017. View Article : Google Scholar : PubMed/NCBI

9 

Sugimura T, Birnbaum SM, Winitz M and Greenstein JP: Quantitative nutritional studies with water-soluble, chemically defined diets. VIII. The forced feeding of diets each lacking in one essential amino acid. Arch Biochem Biophys. 81:448–455. 1959. View Article : Google Scholar : PubMed/NCBI

10 

Kaiser P: Methionine dependence of cancer. Biomolecules. 10:5682020. View Article : Google Scholar : PubMed/NCBI

11 

Wang Z, Yip LY, Lee JHJ, Wu Z, Chew HY, Chong PKW, Teo CC, Ang HY, Peh KLE, Yuan J, et al: Methionine is a metabolic dependency of tumor-initiating cells. Nat Med. 25:825–837. 2019. View Article : Google Scholar : PubMed/NCBI

12 

Gao X, Sanderson SM, Dai Z, Reid MA, Cooper DE, Lu M, Richie JP Jr, Ciccarella A, Calcagnotto A, Mikhael PG, et al: Dietary methionine influences therapy in mouse cancer models and alters human metabolism. Nature. 572:397–401. 2019. View Article : Google Scholar : PubMed/NCBI

13 

Bian Y, Li W, Kremer DM, Sajjakulnukit P, Li S, Crespo J, Nwosu ZC, Zhang L, Czerwonka A, Pawłowska A, et al: Cancer SLC43A2 alters T cell methionine metabolism and histone methylation. Nature. 585:277–282. 2020. View Article : Google Scholar : PubMed/NCBI

14 

Tatekawa S, Ofusa K, Chijimatsu R, Vecchione A, Tamari K, Ogawa K and Ishii H: Methylosystem for cancer sieging strategy. Cancers (Basel). 13:50882021. View Article : Google Scholar : PubMed/NCBI

15 

Kilgour MK, MacPherson S, Zacharias LG, Ellis AE, Sheldon RD, Liu EY, Keyes S, Pauly B, Carleton G, Allard B, et al: 1-Methylnicotinamide is an immune regulatory metabolite in human ovarian cancer. Sci Adv. 7:eabe11742021. View Article : Google Scholar : PubMed/NCBI

16 

Pellagatti A, Armstrong RN, Steeples V, Sharma E, Repapi E, Singh S, Sanchi A, Radujkovic A, Horn P, Dolatshad H, et al: Impact of spliceosome mutations on RNA splicing in myelodysplasia: Dysregulated genes/pathways and clinical associations. Blood. 132:1225–1240. 2018. View Article : Google Scholar : PubMed/NCBI

17 

Figg JW, Barajas JM and Obeng EA: Therapeutic approaches targeting splicing factor mutations in myelodysplastic syndromes and acute myeloid leukemia. Curr Opin Hematol. 28:73–79. 2021. View Article : Google Scholar : PubMed/NCBI

18 

Wang E, Pineda JMB, Kim WJ, Chen S, Bourcier J, Stahl M, Hogg SJ, Bewersdorf JP, Han C, Singer ME, et al: Modulation of RNA splicing enhances response to BCL2 inhibition in leukemia. Cancer Cell. 41:164–180 e8. 2023. View Article : Google Scholar :

19 

Rahman MA, Lin KT, Bradley RK, Abdel-Wahab O and Krainer AR: Recurrent SRSF2 mutations in MDS affect both splicing and NMD. Genes Dev. 34:413–427. 2020. View Article : Google Scholar : PubMed/NCBI

20 

Yang Q, Zhao J, Zhang W, Chen D and Wang Y: Aberrant alternative splicing in breast cancer. J Mol Cell Biol. 11:920–929. 2019. View Article : Google Scholar : PubMed/NCBI

21 

Nanjo S, Wu W, Karachaliou N, Blakely CM, Suzuki J, Chou YT, Ali SM, Kerr DL, Olivas VR, Shue J, et al: Deficiency of the splicing factor RBM10 limits EGFR inhibitor response in EGFR-mutant lung cancer. J Clin Invest. 132:e1450992022. View Article : Google Scholar : PubMed/NCBI

22 

Wan L, Lin KT, Rahman MA, Ishigami Y, Wang Z, Jensen MA, Wilkinson JE, Park Y, Tuveson DA and Krainer AR: Splicing Factor SRSF1 promotes pancreatitis and KRASG12D-mediated pancreatic cancer. Cancer Discov. 13:1678–1695. 2023. View Article : Google Scholar : PubMed/NCBI

23 

Tan C, Cao J, Chen L, Xi X, Wang S, Zhu Y, Yang L, Ma L, Wang D, Yin J, et al: Noncoding RNAs serve as diagnosis and prognosis biomarkers for hepatocellular carcinoma. Clin Chem. 65:905–915. 2019. View Article : Google Scholar : PubMed/NCBI

24 

Johnson LR, Lee DY, Eacret JS, Ye D, June CH and Minn AJ: The immunostimulatory RNA RN7SL1 enables CAR-T cells to enhance autonomous and endogenous immune function. Cell. 184:4981–4995 e14. 2021. View Article : Google Scholar : PubMed/NCBI

25 

Xie X, Liu H, Wang Y, Zhou Y, Yu H, Li G, Ruan Z, Li F, Wang X and Zhang J: Nicotinamide N-methyltransferase enhances resistance to 5-fluorouracil in colorectal cancer cells through inhibition of the ASK1-p38 MAPK pathway. Oncotarget. 7:45837–45848. 2016. View Article : Google Scholar : PubMed/NCBI

26 

Novak Kujundzic R, Prpic M, Dakovic N, Dabelić N, Tomljanović M, Mojzeš A, Fröbe A and Trošelj KG: Nicotinamide N-Methyltransferase in acquisition of stem cell properties and therapy resistance in cancer. Int J Mol Sci. 22:56812021. View Article : Google Scholar : PubMed/NCBI

27 

Rodrigues F, van Hemert M, Steensma HY, Corte-Real M and Leao C: Red fluorescent protein (DsRed) as a reporter in Saccharomyces cerevisiae. J Bacteriol. 183:3791–3794. 2001. View Article : Google Scholar : PubMed/NCBI

28 

Kimura A, Toda Y, Matsumoto Y, Yamamoto H, Yahiro K, Shimada E, Kanahori M, Oyama R, Fukushima S, Nakagawa M, et al: Nuclear β-catenin translocation plays a key role in osteoblast differentiation of giant cell tumor of bone. Sci Rep. 12:134382022. View Article : Google Scholar

29 

Larsson SC, Giovannucci E and Wolk A: Methionine and vitamin B6 intake and risk of pancreatic cancer: A prospective study of Swedish women and men. Gastroenterology. 132:113–118. 2007. View Article : Google Scholar : PubMed/NCBI

30 

Wei DH and Mao QQ: Vitamin B6, vitamin B12 and methionine and risk of pancreatic cancer: A meta-analysis. Nutr J. 19:1112020. View Article : Google Scholar : PubMed/NCBI

31 

Kellogg MK, Miller SC, Tikhonova EB and Karamyshev AL: SRPassing Co-translational Targeting: The role of the signal recognition particle in protein targeting and mRNA protection. Int J Mol Sci. 22:62842021. View Article : Google Scholar : PubMed/NCBI

32 

Ala M: Target c-Myc to treat pancreatic cancer. Cancer Biol Ther. 23:34–50. 2022. View Article : Google Scholar : PubMed/NCBI

33 

Peng YP, Zhu Y, Yin LD, Zhang JJ, Wei JS, Liu X, Liu XC, Gao WT, Jiang KR and Miao Y: PEG10 overexpression induced by E2F-1 promotes cell proliferation, migration, and invasion in pancreatic cancer. J Exp Clin Cancer Res. 36:302017. View Article : Google Scholar : PubMed/NCBI

34 

Oshi M, Patel A, Le L, Tokumaru Y, Yan L, Matsuyama R, Endo I and Takabe K: G2M checkpoint pathway alone is associated with drug response and survival among cell proliferation-related pathways in pancreatic cancer. Am J Cancer Res. 11:3070–3084. 2021.PubMed/NCBI

35 

Ashton TM, McKenna WG, Kunz-Schughart LA and Higgins GS: Oxidative phosphorylation as an emerging target in cancer therapy. Clin Cancer Res. 24:2482–2490. 2018. View Article : Google Scholar : PubMed/NCBI

36 

Long D, Chen K, Yang Y and Tian X: Unfolded protein response activated by endoplasmic reticulum stress in pancreatic cancer: Potential therapeutical target. Front Biosci (Landmark Ed). 26:1689–1696. 2021. View Article : Google Scholar

37 

Luo J: KRAS mutation in pancreatic cancer. Semin Oncol. 48:10–18. 2021. View Article : Google Scholar : PubMed/NCBI

38 

Brierley J, Gospodarowicz MK and Wittekind C: TNM Classification of Malignant Tumours. Wiley Blackwell; Hoboken, NJ: 2017

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Sato H, Meng S, Sasaki K, Kobayashi S, Kido K, Tsuji Y, Arao Y, Saito Y, Iwagami Y, Yamada D, Yamada D, et al: Significance of signal recognition particle 9 nuclear translocation: Implications for pancreatic cancer prognosis and functionality. Int J Oncol 65: 74, 2024.
APA
Sato, H., Meng, S., Sasaki, K., Kobayashi, S., Kido, K., Tsuji, Y. ... Ishii, H. (2024). Significance of signal recognition particle 9 nuclear translocation: Implications for pancreatic cancer prognosis and functionality. International Journal of Oncology, 65, 74. https://doi.org/10.3892/ijo.2024.5662
MLA
Sato, H., Meng, S., Sasaki, K., Kobayashi, S., Kido, K., Tsuji, Y., Arao, Y., Saito, Y., Iwagami, Y., Yamada, D., Tomimaru, Y., Noda, T., Takahashi, H., Motooka, D., Uchida, S., Ofusa, K., Satoh, T., Doki, Y., Eguchi, H., Hara, T., Ishii, H."Significance of signal recognition particle 9 nuclear translocation: Implications for pancreatic cancer prognosis and functionality". International Journal of Oncology 65.1 (2024): 74.
Chicago
Sato, H., Meng, S., Sasaki, K., Kobayashi, S., Kido, K., Tsuji, Y., Arao, Y., Saito, Y., Iwagami, Y., Yamada, D., Tomimaru, Y., Noda, T., Takahashi, H., Motooka, D., Uchida, S., Ofusa, K., Satoh, T., Doki, Y., Eguchi, H., Hara, T., Ishii, H."Significance of signal recognition particle 9 nuclear translocation: Implications for pancreatic cancer prognosis and functionality". International Journal of Oncology 65, no. 1 (2024): 74. https://doi.org/10.3892/ijo.2024.5662
Copy and paste a formatted citation
x
Spandidos Publications style
Sato H, Meng S, Sasaki K, Kobayashi S, Kido K, Tsuji Y, Arao Y, Saito Y, Iwagami Y, Yamada D, Yamada D, et al: Significance of signal recognition particle 9 nuclear translocation: Implications for pancreatic cancer prognosis and functionality. Int J Oncol 65: 74, 2024.
APA
Sato, H., Meng, S., Sasaki, K., Kobayashi, S., Kido, K., Tsuji, Y. ... Ishii, H. (2024). Significance of signal recognition particle 9 nuclear translocation: Implications for pancreatic cancer prognosis and functionality. International Journal of Oncology, 65, 74. https://doi.org/10.3892/ijo.2024.5662
MLA
Sato, H., Meng, S., Sasaki, K., Kobayashi, S., Kido, K., Tsuji, Y., Arao, Y., Saito, Y., Iwagami, Y., Yamada, D., Tomimaru, Y., Noda, T., Takahashi, H., Motooka, D., Uchida, S., Ofusa, K., Satoh, T., Doki, Y., Eguchi, H., Hara, T., Ishii, H."Significance of signal recognition particle 9 nuclear translocation: Implications for pancreatic cancer prognosis and functionality". International Journal of Oncology 65.1 (2024): 74.
Chicago
Sato, H., Meng, S., Sasaki, K., Kobayashi, S., Kido, K., Tsuji, Y., Arao, Y., Saito, Y., Iwagami, Y., Yamada, D., Tomimaru, Y., Noda, T., Takahashi, H., Motooka, D., Uchida, S., Ofusa, K., Satoh, T., Doki, Y., Eguchi, H., Hara, T., Ishii, H."Significance of signal recognition particle 9 nuclear translocation: Implications for pancreatic cancer prognosis and functionality". International Journal of Oncology 65, no. 1 (2024): 74. https://doi.org/10.3892/ijo.2024.5662
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team