Open Access

Targeting drug resistance in glioblastoma (Review)

  • Authors:
    • Jonathan H. Sherman
    • Adam Bobak
    • Tasneem Arsiwala
    • Paul Lockman
    • Sonikpreet Aulakh
  • View Affiliations

  • Published online on: July 9, 2024     https://doi.org/10.3892/ijo.2024.5668
  • Article Number: 80
  • Copyright: © Sherman et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Glioblastoma (GBM) is the most common malignancy of the central nervous system in adults. The current standard of care includes surgery, radiation therapy, temozolomide; and tumor‑treating fields leads to dismal overall survival. There are far limited treatments upon recurrence. Therapies to date are ineffective as a result of several factors, including the presence of the blood‑brain barrier, blood tumor barrier, glioma stem‑like cells and genetic heterogeneity in GBM. In the present review, the potential mechanisms that lead to treatment resistance in GBM and the measures which have been taken so far to attempt to overcome the resistance were discussed. The complex biology of GBM and lack of comprehensive understanding of the development of therapeutic resistance in GBM demands discovery of novel antigens that are targetable and provide effective therapeutic strategies.
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August-2024
Volume 65 Issue 2

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Copy and paste a formatted citation
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Spandidos Publications style
Sherman JH, Bobak A, Arsiwala T, Lockman P and Aulakh S: Targeting drug resistance in glioblastoma (Review). Int J Oncol 65: 80, 2024
APA
Sherman, J.H., Bobak, A., Arsiwala, T., Lockman, P., & Aulakh, S. (2024). Targeting drug resistance in glioblastoma (Review). International Journal of Oncology, 65, 80. https://doi.org/10.3892/ijo.2024.5668
MLA
Sherman, J. H., Bobak, A., Arsiwala, T., Lockman, P., Aulakh, S."Targeting drug resistance in glioblastoma (Review)". International Journal of Oncology 65.2 (2024): 80.
Chicago
Sherman, J. H., Bobak, A., Arsiwala, T., Lockman, P., Aulakh, S."Targeting drug resistance in glioblastoma (Review)". International Journal of Oncology 65, no. 2 (2024): 80. https://doi.org/10.3892/ijo.2024.5668