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Review Open Access

mRNA vaccine development and applications: A special focus on tumors (Review)

  • Authors:
    • Bangjie Chen
    • Yipin Yang
    • Xinyi Wang
    • Wenzhi Yang
    • You Lu
    • Daoyue Wang
    • Enba Zhuo
    • Yanchao Tang
    • Junhong Su
    • Guozheng Tang
    • Song Shao
    • Kangsheng Gu
  • View Affiliations / Copyright

    Affiliations: Department of Oncology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230022, P.R. China, Department of Radiation Oncology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230022, P.R. China, First Clinical Medical College, Anhui Medical University, Hefei, Anhui 230022, P.R. China, Department of Anesthesiology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230022, P.R. China, Department of Rehabilitation, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230022, P.R. China, Department of Orthopedics, Lu'an Hospital of Anhui Medical University, Lu'an, Anhui 237008, P.R. China
    Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 81
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    Published online on: July 9, 2024
       https://doi.org/10.3892/ijo.2024.5669
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Abstract

Cancer is characterized by unlimited proliferation and metastasis, and traditional therapeutic strategies usually result in the acquisition of drug resistance, thus highlighting the need for more personalized treatment. mRNA vaccines transfer the gene sequences of exogenous target antigens into human cells through transcription and translation to stimulate the body to produce specific immune responses against the encoded proteins, so as to enable the body to obtain immune protection against said antigens; this approach may be adopted for personalized cancer therapy. Since the recent coronavirus pandemic, the development of mRNA vaccines has seen substantial progress and widespread adoption. In the present review, the development of mRNA vaccines, their mechanisms of action, factors influencing their function and the current clinical applications of the vaccine are discussed. A focus is placed on the application of mRNA vaccines in cancer, with the aim of highlighting unique advances and the remaining challenges of this novel and promising therapeutic approach.
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Copy and paste a formatted citation
Spandidos Publications style
Chen B, Yang Y, Wang X, Yang W, Lu Y, Wang D, Zhuo E, Tang Y, Su J, Tang G, Tang G, et al: mRNA vaccine development and applications: A special focus on tumors (Review). Int J Oncol 65: 81, 2024.
APA
Chen, B., Yang, Y., Wang, X., Yang, W., Lu, Y., Wang, D. ... Gu, K. (2024). mRNA vaccine development and applications: A special focus on tumors (Review). International Journal of Oncology, 65, 81. https://doi.org/10.3892/ijo.2024.5669
MLA
Chen, B., Yang, Y., Wang, X., Yang, W., Lu, Y., Wang, D., Zhuo, E., Tang, Y., Su, J., Tang, G., Shao, S., Gu, K."mRNA vaccine development and applications: A special focus on tumors (Review)". International Journal of Oncology 65.2 (2024): 81.
Chicago
Chen, B., Yang, Y., Wang, X., Yang, W., Lu, Y., Wang, D., Zhuo, E., Tang, Y., Su, J., Tang, G., Shao, S., Gu, K."mRNA vaccine development and applications: A special focus on tumors (Review)". International Journal of Oncology 65, no. 2 (2024): 81. https://doi.org/10.3892/ijo.2024.5669
Copy and paste a formatted citation
x
Spandidos Publications style
Chen B, Yang Y, Wang X, Yang W, Lu Y, Wang D, Zhuo E, Tang Y, Su J, Tang G, Tang G, et al: mRNA vaccine development and applications: A special focus on tumors (Review). Int J Oncol 65: 81, 2024.
APA
Chen, B., Yang, Y., Wang, X., Yang, W., Lu, Y., Wang, D. ... Gu, K. (2024). mRNA vaccine development and applications: A special focus on tumors (Review). International Journal of Oncology, 65, 81. https://doi.org/10.3892/ijo.2024.5669
MLA
Chen, B., Yang, Y., Wang, X., Yang, W., Lu, Y., Wang, D., Zhuo, E., Tang, Y., Su, J., Tang, G., Shao, S., Gu, K."mRNA vaccine development and applications: A special focus on tumors (Review)". International Journal of Oncology 65.2 (2024): 81.
Chicago
Chen, B., Yang, Y., Wang, X., Yang, W., Lu, Y., Wang, D., Zhuo, E., Tang, Y., Su, J., Tang, G., Shao, S., Gu, K."mRNA vaccine development and applications: A special focus on tumors (Review)". International Journal of Oncology 65, no. 2 (2024): 81. https://doi.org/10.3892/ijo.2024.5669
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