Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
International Journal of Oncology
Join Editorial Board Propose a Special Issue
Print ISSN: 1019-6439 Online ISSN: 1791-2423
Journal Cover
September-2024 Volume 65 Issue 3

Full Size Image

Cover Legend PDF

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
September-2024 Volume 65 Issue 3

Full Size Image

Cover Legend PDF

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Review Open Access

Role of miRNA‑122 in cancer (Review)

  • Authors:
    • Jing Zhang
    • Linghua Wu
    • Rong Ding
    • Xin Deng
    • Zeshan Chen
  • View Affiliations / Copyright

    Affiliations: Department of Respiratory Medicine, Taizhou Fourth People's Hospital, Taizhou, Jiangsu 225300, P.R. China, Department of Traditional Chinese Medicine, Taizhou Fifth People's Hospital, Taizhou, Jiangsu 225766, P.R. China, School of Basic Medical Sciences, Guangxi University of Traditional Chinese Medicine, Nanning, Guangxi 530200, P.R. China, Department of Traditional Chinese Medicine, Guangxi Zhuang Autonomous Region People's Hospital, Nanning, Guangxi 530016, P.R. China
    Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 83
    |
    Published online on: July 18, 2024
       https://doi.org/10.3892/ijo.2024.5671
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

MicroRNAs (miRNAs) are small non‑coding RNAs that serve key roles in cell proliferation, migration, invasion and apoptosis by regulating gene expression. In malignant tumors, miRNA‑122 serves either as a tumor suppressor or oncogene, influencing tumor progression via downstream gene targeting. However, the precise role of miRNA‑122 in cancer remains unclear. miRNA‑122 is a potential biomarker and modulator of radiotherapy and chemotherapy. The present review aimed to summarize the roles of miRNA‑122 in cancer, its potential as a biomarker for diagnosis and prognosis and its implications in cancer therapy, including radiotherapy and chemotherapy, alongside strategies for systemic delivery.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

Figure 8

View References

1 

Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA and Jemal A: Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 68:394–424. 2018. View Article : Google Scholar : PubMed/NCBI

2 

Mattiuzzi C and Lippi G: Current cancer epidemiology. J Epidemiol Glob Health. 9:217–222. 2019. View Article : Google Scholar : PubMed/NCBI

3 

Britton C, Laing R and Devaney E: Small RNAs in parasitic nematodes-forms and functions. Parasitology. 147:855–864. 2020. View Article : Google Scholar

4 

Morales-Martínez M and Vega MI: Role of MicroRNA-7 (MiR-7) in cancer physiopathology. Int J Mol Sci. 23:90912022. View Article : Google Scholar : PubMed/NCBI

5 

Hebbar S, Panzade G, Vashisht AA, Wohlschlegel JA, Veksler-Lublinsky I and Zinovyeva AY: Functional identification of microRNA-centered complexes in C: elegans. Sci Rep. 12:71332022. View Article : Google Scholar

6 

Hill M and Tran N: miRNA interplay: Mechanisms and consequences in cancer. Dis Model Mech. 14:dmm0476622021. View Article : Google Scholar : PubMed/NCBI

7 

Chen Y and Wang X: miRDB: An online database for prediction of functional microRNA targets. Nucleic Acids Res. 48(D1): D127–D131. 2020. View Article : Google Scholar :

8 

Wang Y, Xing QF, Liu XQ, Guo ZJ, Li CY and Sun G: MiR-122 targets VEGFC in bladder cancer to inhibit tumor growth and angiogenesis. Am J Transl Res. 8:3056–3066. 2016.PubMed/NCBI

9 

Chun KH: Molecular Targets and signaling pathways of microRNA-122 in hepatocellular carcinoma. Pharmaceutics. 14:13802022. View Article : Google Scholar : PubMed/NCBI

10 

Collison AM, Sokulsky LA, Kepreotes E, Pereira de Siqueira A, Morten M, Edwards MR, Walton RP, Bartlett NW, Yang M, Nguyen TH, et al: miR-122 promotes virus-induced lung disease by targeting SOCS1. JCI Insight. 6:e1279332021. View Article : Google Scholar : PubMed/NCBI

11 

Wang M, Zheng H, Zhou X, Zhang J and Shao G: miR-122 promotes diabetic retinopathy through targeting TIMP3. Anim Cells Syst (Seoul). 24:275–281. 2020. View Article : Google Scholar : PubMed/NCBI

12 

Scott KM, Cohen DJ, Boyan BD and Schwartz Z: miR-122 and the WNT/β-catenin pathway inhibit effects of both interleukin-1β and tumor necrosis factor-α in articular chondrocytes in vitro. J Cell Biochem. 123:1053–1063. 2022. View Article : Google Scholar : PubMed/NCBI

13 

Li A, Wu J, Zhai A, Qian J, Qian J, Wang X, Qaria MA, Zhang Q, Li Y, Fang Y, Kao W, et al: HBV triggers APOBEC2 expression through miR-122 regulation and affects the proliferation of liver cancer cells. Int J Oncol. 55:1137–1148. 2019.PubMed/NCBI

14 

Smolarz B, Durczyński A, Romanowicz H, Szyłło K and Hogendorf P: miRNAs in cancer (review of literature). Int J Mol Sci. 23:28052022. View Article : Google Scholar : PubMed/NCBI

15 

Liu Y, Song JW, Lin JY, Miao R and Zhong JC: Roles of MicroRNA-122 in cardiovascular fibrosis and related diseases. Cardiovasc Toxicol. 20:463–473. 2020. View Article : Google Scholar : PubMed/NCBI

16 

Guo L, Yin M and Wang Y: CREB1, a direct target of miR-122, promotes cell proliferation and invasion in bladder cancer. Oncol Lett. 16:3842–3848. 2018.PubMed/NCBI

17 

Qin H, Sha J, Jiang C, Gao X, Qu L, Yan H, Xu T, Jiang Q and Gao H: miR-122 inhibits metastasis and epithelial-mesenchymal transition of non-small-cell lung cancer cells. Onco Targets Ther. 8:3175–3184. 2015.PubMed/NCBI

18 

Chandimali N, Huynh DL, Zhang JJ, Lee JC, Yu DY, Jeong DK and Kwon T: MicroRNA-122 negatively associates with peroxiredoxin-II expression in human gefitinib-resistant lung cancer stem cells. Cancer Gene Ther. 26:292–304. 2019. View Article : Google Scholar :

19 

Kong L, Wu Q, Zhao L, Ye J, Li N and Yang H: Upregulated lncRNA-UCA1 contributes to metastasis of bile duct carcinoma through regulation of miR-122/CLIC1 and activation of the ERK/MAPK signaling pathway. Cell Cycle. 18:1212–1228. 2019. View Article : Google Scholar : PubMed/NCBI

20 

Yang Y, Li Q and Guo L: MicroRNA-122 acts as tumor suppressor by targeting TRIM29 and blocking the activity of PI3K/AKT signaling in nasopharyngeal carcinoma in vitro. Mol Med Rep. 17:8244–8252. 2018.PubMed/NCBI

21 

Liao B, Wang Z, Zhu Y, Wang M and Liu Y: Long noncoding RNA DRAIC acts as a microRNA-122 sponge to facilitate nasopharyngeal carcinoma cell proliferation, migration and invasion via regulating SATB1. Artif Cells Nanomed Biotechnol. 47:3585–3597. 2019. View Article : Google Scholar : PubMed/NCBI

22 

Liu H, Hou T, Ju W, Xing Y, Zhang X and Yang J: MicroRNA-122 downregulates Rho-associated protein kinase 2 expression and inhibits the proliferation of prostate carcinoma cells. Mol Med Rep. 19:3882–3888. 2019.PubMed/NCBI

23 

Perez-Añorve IX, Gonzalez-De la Rosa CH, Soto-Reyes E, Beltran-Anaya FO, Del Moral-Hernandez O, Salgado-Albarran M, Angeles-Zaragoza O, Gonzalez-Barrios JA, Landero-Huerta DA and Chavez-Saldaña M: New insights into radioresistance in breast cancer identify a dual function of miR-122 as a tumor suppressor and oncomiR. Mol Oncol. 13:1249–1267. 2019. View Article : Google Scholar : PubMed/NCBI

24 

Zhang Y and Tang L: Inhibition of breast cancer cell proliferation and tumorigenesis by long non-coding RNA RPPH1 down-regulation of miR-122 expression. Cancer Cell Int. 17:1092017. View Article : Google Scholar : PubMed/NCBI

25 

Li XN, Yang H and Yang T: miR-122 inhibits hepatocarcinoma cell progression by targeting LMNB2. Oncol Res. 28:41–49. 2020. View Article : Google Scholar

26 

Iino I, Kikuchi H, Miyazaki S, Hiramatsu Y, Ohta M, Kamiya K, Kusama Y, Baba S, Setou M and Konno H: Effect of miR-122 and its target gene cationic amino acid transporter 1 on colorectal liver metastasis. Cancer Sci. 104:624–630. 2013. View Article : Google Scholar : PubMed/NCBI

27 

Hua Y, Zhu Y, Zhang J, Zhu Z, Ning Z, Chen H, Liu L, Chen Z and Meng Z: miR-122 targets X-linked inhibitor of apoptosis protein to sensitize oxaliplatin-resistant colorectal cancer cells to oxaliplatin-mediated cytotoxicit. Cell Physiol Biochem. 51:2148–2159. 2018. View Article : Google Scholar

28 

Wang J, Yu PY, Yu JP, Luo JD, Sun ZQ, Sun F, Kong Z and Wang JL: KIF22 promotes progress of esophageal squamous cell carcinoma cells and is negatively regulated by miR-122. Am J Transl Res. 13:4152–4166. 2021.PubMed/NCBI

29 

Ding CQ, Deng WS, Yin XF and Ding XD: MiR-122 inhibits cell proliferation and induces apoptosis by targeting runt-related transcription factors 2 in human glioma. Eur Rev Med Pharmacol Sci. 22:4925–4933. 2018.PubMed/NCBI

30 

Chen C, Deng L, Nie DK, Jia F, Fu LS, Wan ZQ and Lan Q: Circular RNA Pleiotrophin promotes carcinogenesis in glioma via regulation of microRNA-122/SRY-box transcription factor 6 axis. Eur J Cancer Prev. 29:165–173. 2020. View Article : Google Scholar

31 

Fan Y, Ma X, Li H, Gao Y, Huang Q, Zhang Y, Bao X, Du Q, Luo G, Liu K, et al: miR-122 promotes metastasis of clear-cell renal cell carcinoma by downregulating Dicer. Int J Cancer. 142:547–560. 2018. View Article : Google Scholar

32 

Nie W, Ni D, Ma X, Zhang Y, Gao Y, Peng C and Zhang X: miR-122 promotes proliferation and invasion of clear cell renal cell carcinoma by suppressing Forkhead box O3. Int J Oncol. 54:559–571. 2019.

33 

Ma J, Wu Q, Zhang Y, Li J, Yu Y, Pan Q and Sun F: MicroRNA sponge blocks the tumor-suppressing functions of microRNA-122 in human hepatoma and osteosarcoma cells. Oncol Rep. 32:2744–2752. 2014. View Article : Google Scholar : PubMed/NCBI

34 

Yang Y, Liu Y, Liu W, Li C, Liu Y, Hu W and Song H: miR-122 inhibits the cervical cancer development by targeting the oncogene RAD21. Biochem Genet. 60:303–314. 2022. View Article : Google Scholar

35 

Siegel RL, Miller KD, Fuchs HE and Jemal A: Cancer statistics, 2021. CA Cancer J Clin. 71:7–33. 2021. View Article : Google Scholar : PubMed/NCBI

36 

Bossi P, Chan AT, Licitra L, Trama A, Orlandi E, Hui EP, Halámková J, Mattheis S, Baujat B, Hardillo J, et al: Nasopharyngeal carcinoma: ESMO-EURACAN clinical practice guidelines for diagnosis, treatment and follow-up†. Ann Oncol. 32:452–465. 2021. View Article : Google Scholar

37 

Chelakkot C, Chelakkot VS, Shin Y and Song K: Modulating glycolysis to improve cancer therapy. Int J Mol Sci. 24:26062023. View Article : Google Scholar : PubMed/NCBI

38 

Li TE, Wang S, Shen XT, Zhang Z, Chen M, Wang H, Zhu Y, Xu D, Hu BY, Wei R, et al: PKM2 drives hepatocellular carcinoma progression by inducing immunosuppressive microenvironment. Front Immunol. 11:5899972020. View Article : Google Scholar : PubMed/NCBI

39 

Zhu Z, Tang G and Yan J: MicroRNA-122 regulates docetaxel resistance of prostate cancer cells by regulating PKM2. Exp Ther Med. 20:2472020. View Article : Google Scholar : PubMed/NCBI

40 

Gong H, Zhou L, Khelfat L, Qiu G, Wang Y, Mao K and Chen W: Rho-associated protein kinase (ROCK) promotes proliferation and migration of PC-3 and DU145 prostate cancer cells by targeting LIM kinase 1 (LIMK1) and matrix metalloproteinase-2 (MMP-2). Med Sci Monit. 25:3090–3099. 2019. View Article : Google Scholar : PubMed/NCBI

41 

Chen X, Yin L, Xu H, Rong J, Feng M, Jiang D and Bai Y: Knockdown of RhoA expression reverts enzalutamide resistance via the P38 MAPK pathway in castration-resistant prostate cancer. Recent Pat Anticancer Drug Discov. 18:92–99. 2023. View Article : Google Scholar

42 

Sato K, Glaser S, Alvaro D, Meng F, Francis H and Alpini G: Cholangiocarcinoma: Novel therapeutic targets. Expert Opin Ther Targets. 24:345–357. 2020. View Article : Google Scholar : PubMed/NCBI

43 

Liu N, Jiang F, He TL, Zhang JK, Zhao J, Wang C, Jiang GX, Cao LP, Kang PC, Zhong XY, et al: The roles of MicroRNA-122 overexpression in inhibiting proliferation and invasion and stimulating apoptosis of human cholangiocarcinoma cells. Sci Rep. 5:165662015. View Article : Google Scholar : PubMed/NCBI

44 

Wu C, Zhang J, Cao X, Yang Q and Xia D: Effect of Mir-122 on human cholangiocarcinoma proliferation, invasion, and apoptosis through P53 expression. Med Sci Monit. 22:2685–2690. 2016. View Article : Google Scholar : PubMed/NCBI

45 

Haibe Y, Kreidieh M, El Hajj H, Khalifeh I, Mukherji D, Temraz S and Shamseddine A: Resistance mechanisms to anti-angiogenic therapies in cancer. Front Oncol. 10:2212020. View Article : Google Scholar : PubMed/NCBI

46 

Wilkinson L and Gathani T: Understanding breast cancer as a global health concern. Br J Radiol. 95:202110332022. View Article : Google Scholar :

47 

Anwanwan D, Singh SK, Singh S, Saikam V and Singh R: Challenges in liver cancer and possible treatment approaches. Biochim Biophys Acta Rev Cancer. 1873:1883142020. View Article : Google Scholar :

48 

Wang SC, Lin XL, Li J, Zhang TT, Wang HY, Shi JW, Yang S, Zhao WT, Xie RY, Wei F, et al: MicroRNA-122 triggers mesenchymal-epithelial transition and suppresses hepatocellular carcinoma cell motility and invasion by targeting RhoA. PloS One. 9:e1013302014. View Article : Google Scholar : PubMed/NCBI

49 

Yahya SMM, Fathy SA, El-Khayat ZA, El-Toukhy SE, Hamed AR, Hegazy MGA and Nabih HK: Possible role of microRNA-122 in Modulating multidrug resistance of hepatocellular carcinoma. Indian J Clin Biochem. 33:21–30. 2018. View Article : Google Scholar : PubMed/NCBI

50 

Duncan AW: Hepatocyte ploidy modulation in liver cancer. EMBO Rep. 21:e519222020. View Article : Google Scholar : PubMed/NCBI

51 

Hsu SH, Delgado ER, Otero PA, Teng KY, Kutay H, Meehan KM, Moroney JB, Monga JK, Hand NJ, Friedman JR, et al: MicroRNA-122 regulates polyploidization in the murine liver. Hepatology. 64:599–615. 2016. View Article : Google Scholar : PubMed/NCBI

52 

Matsumoto T, Wakefield L, Peters A, Peto M, Spellman P and Grompe M: Proliferative polyploid cells give rise to tumors via ploidy reduction. Nat Commun. 12:6462021. View Article : Google Scholar : PubMed/NCBI

53 

Matsumoto T: Implications of polyploidy and ploidy alterations in hepatocytes in liver injuries and cancers. Int J Mol Sci. 23:94092022. View Article : Google Scholar : PubMed/NCBI

54 

Wang F, Long J, Li L, Wu ZX, Da TT, Wang XQ, Huang C, Jiang YH, Yao XQ, Ma HQ, et al: Single-cell and spatial transcriptome analysis reveals the cellular heterogeneity of liver metastatic colorectal cancer. Sci Adv. 9:eadf54642023. View Article : Google Scholar : PubMed/NCBI

55 

Huang FL and Yu SJ: Esophageal cancer: Risk factors, genetic association, and treatment. Asian J Surg. 41:210–215. 2018. View Article : Google Scholar

56 

Zhou K, Yan Y and Zhao S: Esophageal cancer-selective expression of TRAIL mediated by MREs of miR-143 and miR-122. Tumour Biology: Tumour Biol. 35:5787–5795. 2014. View Article : Google Scholar : PubMed/NCBI

57 

Samarakkody AS, Shin NY and Cantor AB: Role of RUNX family transcription factors in DNA damage response. Mol Cells. 43:99–106. 2020.PubMed/NCBI

58 

DiNardo CD, Erba HP, Freeman SD and Wei AH: Acute myeloid leukaemia. Lancet. 401:2073–2086. 2023. View Article : Google Scholar : PubMed/NCBI

59 

Zhang TJ, Qian Z, Wen XM, Zhou JD, Li XX, Xu ZJ, Ma JC, Zhang ZH, Lin J and Qian J: Lower expression of bone marrow miR-122 is an independent risk factor for overall survival in cytogenetically normal acute myeloid leukemia. Pathol Res Pract. 214:896–901. 2018. View Article : Google Scholar : PubMed/NCBI

60 

Yang J, Yuan Y, Yang X, Hong Z and Yang L: Decreased expression of microRNA-122 is associated with an unfavorable prognosis in childhood acute myeloid leukemia and function analysis indicates a therapeutic potential. Pathol Res Pract. 213:1166–1172. 2017. View Article : Google Scholar : PubMed/NCBI

61 

Wang Y, Wang C, Xia M, Tian Z, Zhou J, Berger JM, Zhang XH and Xiao H: Engineering small-molecule and protein drugs for targeting bone tumors. Mol Ther. 32:1219–1237. 2024. View Article : Google Scholar : PubMed/NCBI

62 

Liu B, Yao S and Zhou J: Micro-RNA 122 and micro-RNA 96 affected human osteosarcoma biological behavior and associated with prognosis of patients with osteosarcoma. Biosci Rep. 40:BSR202015292020. View Article : Google Scholar : PubMed/NCBI

63 

Sun L, Liu X, Pan B, Hu X, Zhu Y, Su Y, Guo Z, Zhang G, Xu M, Xu X, et al: Serum exosomal miR-122 as a potential diagnostic and prognostic biomarker of colorectal cancer with liver metastasis. J Cancer. 11:630–637. 2020. View Article : Google Scholar : PubMed/NCBI

64 

Tang Y, Zhao S, Wang J, Li D, Ren Q and Tang Y: Plasma miR-122 as a potential diagnostic and prognostic indicator in human glioma. Neurol Sci. 38:1087–1092. 2017. View Article : Google Scholar : PubMed/NCBI

65 

Zhan G, Jiang H, Yang R and Yang K: miR-122 and miR-197 expressions in hepatic carcinoma patients before and after chemotherapy and their effect on patient prognosis. Am J Transl Res. 13:6731–6737. 2021.PubMed/NCBI

66 

Cochetti G, Cari L, Nocentini G, Maulà V, Suvieri C, Cagnani R, Rossi De Vermandois JA and Mearini E: Detection of urinary miRNAs for diagnosis of clear cell renal cell carcinoma. Sci Rep. 10:212902020. View Article : Google Scholar : PubMed/NCBI

67 

Chen Q, Ge X, Zhang Y, Xia H, Yuan D, Tang Q, Chen L, Pang X, Leng W and Bi F: Plasma miR-122 and miR-192 as potential novel biomarkers for the early detection of distant metastasis of gastric cancer. Oncol Rep. 31:1863–1870. 2014. View Article : Google Scholar : PubMed/NCBI

68 

Nakamura K, Hiyake N, Hamada T, Yokoyama S, Mori K, Yamashiro K, Beppu M, Sagara Y, Sagara Y and Sugiura T: Circulating microRNA panel as a potential novel biomarker for oral squamous cell carcinoma diagnosis. Cancers (Basel). 13:4492021. View Article : Google Scholar : PubMed/NCBI

69 

Maierthaler M, Benner A, Hoffmeister M, Surowy H, Jansen L, Knebel P, Chang-Claude J, Brenner H and Burwinkel B: Plasma miR-122 and miR-200 family are prognostic markers in colorectal cancer. Int J Cancer. 140:176–187. 2017. View Article : Google Scholar

70 

Deng P, Li M and Wu Y: The predictive efficacy of serum exosomal microRNA-122 and microRNA-148a for hepatocellular carcinoma based on smart healthcare. J Healthc Eng. 2022:59145412022. View Article : Google Scholar : PubMed/NCBI

71 

Ha SY, Yu JI, Choi C, Kang SY, Joh JW, Paik SW, Kim S, Kim M, Park HC and Park CK: Prognostic significance of miR-122 expression after curative resection in patients with hepatocellular carcinoma. Sci Rep. 9:147382019. View Article : Google Scholar : PubMed/NCBI

72 

Kim SS, Nam JS, Cho HJ, Won JH, Kim JW, Ji JH, Yang MJ, Park JH, Noh CK, Shin SJ, et al: Plasma micoRNA-122 as a predictive marker for treatment response following transarterial chemoembolization in patients with hepatocellular carcinoma. J Gastroenterol Hepatol. 32:199–207. 2017. View Article : Google Scholar

73 

Wang S, Liu Y, Feng Y, Zhang J, Swinnen J, Li Y and Ni Y: A review on curability of cancers: More efforts for novel therapeutic options are needed. Cancers (Basel). 11:17822019. View Article : Google Scholar : PubMed/NCBI

74 

He J, Xie G, Tong J, Peng Y, Huang H, Li J, Wang N and Liang H: Overexpression of microRNA-122 re-sensitizes 5-FU-resistant colon cancer cells to 5-FU through the inhibition of PKM2 in vitro and in vivo. Cell Biochem Biophys. 70:1343–1350. 2014. View Article : Google Scholar : PubMed/NCBI

75 

Dai J, Hao Y, Chen X, Yu Q and Wang B: miR-122/SENP1 axis confers stemness and chemoresistance to liver cancer through Wnt/β-catenin signaling. Oncol Lett. 26:3902023. View Article : Google Scholar

76 

Cao F and Yin LX: miR-122 enhances sensitivity of hepatocellular carcinoma to oxaliplatin via inhibiting MDR1 by targeting Wnt/β-catenin pathway. Exp Mol Pathol. 106:34–43. 2019. View Article : Google Scholar

77 

Ma D, Jia H, Qin M, Dai W, Wang T, Liang E, Dong G, Wang Z, Zhang Z and Feng F: MiR-122 induces radiosensitization in non-small cell lung cancer cell line. Int J Mol Sci. 16:22137–22150. 2015. View Article : Google Scholar : PubMed/NCBI

78 

Xu G, Bu S, Wang X and Ge H: MiR-122 radiosensitize hepatocellular carcinoma cells by suppressing cyclin G1. Int J Radiat Biol. 98:11–17. 2022. View Article : Google Scholar

79 

Zhao ZL, Liu C, Wang QZ, Wu HW and Zheng JW: Engineered exosomes for targeted delivery of miR-187-3p suppress the viability of hemangioma stem cells by targeting notch signaling. Ann Transl Med. 10:6212022. View Article : Google Scholar : PubMed/NCBI

80 

Wu L, Zhou W, Lin L, Chen A, Feng J, Qu X, Zhang H and Yue J: Delivery of therapeutic oligonucleotides in nanoscale. Bioact Mater. 7:292–323. 2021.PubMed/NCBI

81 

Liang Y, Xu X, Li X, Xiong J, Li B, Duan L, Wang D and Xia J: Chondrocyte-targeted MicroRNA delivery by engineered exosomes toward a cell-free osteoarthritis therapy. ACS Appl Mater Interfaces. 12:36938–36947. 2020. View Article : Google Scholar : PubMed/NCBI

82 

Lou G, Song X, Yang F, Wu S, Wang J, Chen Z and Liu Y: Exosomes derived from miR-122-modified adipose tissue-derived MSCs increase chemosensitivity of hepatocellular carcinoma. J Hematol Oncol. 8:1222015. View Article : Google Scholar : PubMed/NCBI

83 

Sweef O, Zaabout E, Bakheet A, Halawa M, Gad I, Akela M, Tousson E, Abdelghany A and Furuta S: Unraveling therapeutic opportunities and the diagnostic potential of microRNAs for human lung cancer. Pharmaceutics. 15:20612023. View Article : Google Scholar : PubMed/NCBI

84 

Li X, Le Y, Zhang Z, Nian X, Liu B and Yang X: Viral vector-based gene therapy. Int J Mol Sci. 24:77362023. View Article : Google Scholar : PubMed/NCBI

85 

Yin L, Keeler GD, Zhang Y, Hoffman BE, Ling C, Qing K and Srivastava A: AAV3-miRNA vectors for growth suppression of human hepatocellular carcinoma cells in vitro and human liver tumors in a murine xenograft model in vivo. Gene Ther. 28:422–434. 2021. View Article : Google Scholar :

86 

Xiao F, Chen J, Lian C, Han P and Zhang C: Tumor necrosis factor-related apoptosis-inducing ligand induces cytotoxicity specific to osteosarcoma by microRNA response elements. Mol Med Rep. 11:739–745. 2015. View Article : Google Scholar

87 

Zhang J, Li D, Zhang R, Peng R and Li J: Delivery of microRNA-21-sponge and pre-microRNA-122 by MS2 virus-like particles to therapeutically target hepatocellular carcinoma cells. Exp Biol Med (Maywood). 246:2463–2472. 2021. View Article : Google Scholar : PubMed/NCBI

88 

Shui M, Chen Z, Chen Y, Yuan Q, Li H, Vong CT, Farag MA and Wang S: Engineering polyphenol-based carriers for nucleic acid delivery. Theranostics. 13:3204–3223. 2023. View Article : Google Scholar : PubMed/NCBI

89 

Yan Y, Liu XY, Lu A, Wang XY, Jiang LX and Wang JC: Non-viral vectors for RNA delivery. J Control Release. 342:241–279. 2022. View Article : Google Scholar : PubMed/NCBI

90 

Sendi H, Yazdimamaghani M, Hu M, Sultanpuram N, Wang J, Moody AS, McCabe E, Zhang J, Graboski A, Li L, et al: Nanoparticle delivery of miR-122 inhibits colorectal cancer liver metastasis. Cancer Res. 82:105–113. 2022. View Article : Google Scholar :

91 

Guo H, Xu M, Cao Z, Li W, Chen L, Xie X, Wang W and Liu J: Ultrasound-assisted miR-122-loaded polymeric nanodroplets for hepatocellular carcinoma gene therapy. Mol Pharm. 17:541–553. 2020.

92 

Zeng X, Yuan Y, Wang T, Wang H, Hu X, Fu Z, Zhang G, Liu B and Lu G: Targeted imaging and induction of apoptosis of drug-resistant hepatoma cells by miR-122-loaded graphene-InP nanocompounds. J Nanobiotechnology. 15:92017. View Article : Google Scholar : PubMed/NCBI

93 

Zhang HT, Sun J, Yan Y, Cui SH, Wang H, Wang CH, Qiu C, Chen X, Ding JS, Qian HG, et al: Encapsulated microRNA by gemcitabine prodrug for cancer treatment. J Control Release. 316:317–330. 2019. View Article : Google Scholar : PubMed/NCBI

94 

Tang Z, Xu Z, Zhu X and Zhang J: New insights into molecules and pathways of cancer metabolism and therapeutic implications. Cancer Commun (Lond). 41:16–36. 2021. View Article : Google Scholar

95 

Novikov NM, Zolotaryova SY, Gautreau AM and Denisov EV: Mutational drivers of cancer cell migration and invasion. Br J Cancer. 124:102–114. 2021. View Article : Google Scholar :

96 

Hsu KH, Wei CW, Su YR, Chou T, Lin YL, Yang FC, Tsou AP, Hsu CL, Tseng PH, Chen NJ, et al: Upregulation of RelB in the miR-122 knockout mice contributes to increased levels of proinflammatory chemokines/cytokines in the liver and macrophages. Immunol Lett. 226:22–30. 2020. View Article : Google Scholar : PubMed/NCBI

97 

Nabih HK: The significance of HCV viral load in the incidence of HCC: A correlation between Mir-122 and CCL2. J Gastrointest Cancer. 51:412–417. 2020. View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Zhang J, Wu L, Ding R, Deng X and Chen Z: Role of miRNA‑122 in cancer (Review). Int J Oncol 65: 83, 2024.
APA
Zhang, J., Wu, L., Ding, R., Deng, X., & Chen, Z. (2024). Role of miRNA‑122 in cancer (Review). International Journal of Oncology, 65, 83. https://doi.org/10.3892/ijo.2024.5671
MLA
Zhang, J., Wu, L., Ding, R., Deng, X., Chen, Z."Role of miRNA‑122 in cancer (Review)". International Journal of Oncology 65.3 (2024): 83.
Chicago
Zhang, J., Wu, L., Ding, R., Deng, X., Chen, Z."Role of miRNA‑122 in cancer (Review)". International Journal of Oncology 65, no. 3 (2024): 83. https://doi.org/10.3892/ijo.2024.5671
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang J, Wu L, Ding R, Deng X and Chen Z: Role of miRNA‑122 in cancer (Review). Int J Oncol 65: 83, 2024.
APA
Zhang, J., Wu, L., Ding, R., Deng, X., & Chen, Z. (2024). Role of miRNA‑122 in cancer (Review). International Journal of Oncology, 65, 83. https://doi.org/10.3892/ijo.2024.5671
MLA
Zhang, J., Wu, L., Ding, R., Deng, X., Chen, Z."Role of miRNA‑122 in cancer (Review)". International Journal of Oncology 65.3 (2024): 83.
Chicago
Zhang, J., Wu, L., Ding, R., Deng, X., Chen, Z."Role of miRNA‑122 in cancer (Review)". International Journal of Oncology 65, no. 3 (2024): 83. https://doi.org/10.3892/ijo.2024.5671
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team