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Tumor‑associated macrophages activated in the tumor environment of hepatocellular carcinoma: Characterization and treatment (Review)

  • Authors:
    • Mingkai Yu
    • Haixia Yu
    • Hongmei Wang
    • Xiaoya Xu
    • Zhaoqing Sun
    • Wenshuai Chen
    • Miaomiao Yu
    • Chunhua Liu
    • Mingchun Jiang
    • Xiaowei Zhang
  • View Affiliations / Copyright

    Affiliations: School of Clinical Medicine and Basic Medical Science, Shandong First Medical University (Shandong Academy of Medical Sciences), Jinan, Shandong 250000, P.R. China, Pharmacy College, Shandong First Medical University (Shandong Academy of Medical Sciences), Jinan, Shandong 250000, P.R. China, Department of Pharmacology, School of Medicine, Southeast University, Nanjing, Jiangsu 210009, P.R. China, Department of Physiology and Neurobiology, Shandong First Medical University (Shandong Academy of Medical Sciences), Jinan, Shandong 250000, P.R. China, Department of Gastroenterology, The Second Affiliated Hospital of Shandong First Medical University, Taian, Shandong 271000, P.R. China
    Copyright: © Yu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 100
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    Published online on: September 5, 2024
       https://doi.org/10.3892/ijo.2024.5688
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Abstract

Hepatocellular carcinoma (HCC) tissue is rich in dendritic cells, T cells, B cells, macrophages, natural killer cells and cellular stroma. Together they form the tumor microenvironment (TME), which is also rich in numerous cytokines. Tumor‑associated macrophages (TAMs) are involved in the regulation of tumor development. TAMs in HCC receive stimuli in different directions, polarize in different directions and release different cytokines to regulate the development of HCC. TAMs are mostly divided into two cell phenotypes: M1 and M2. M1 TAMs secrete pro‑inflammatory mediators, and M2 TAMs secrete a variety of anti‑inflammatory and pro‑tumorigenic substances. The TAM polarization in HCC tumors is M2. Both direct and indirect methods for TAMs to regulate the development of HCC are discussed. TAMs indirectly support HCC development by promoting peripheral angiogenesis and regulating the immune microenvironment of the TME. In terms of the direct regulation between TAMs and HCC cells, the present review mainly focuses on the molecular mechanism. TAMs are involved in both the proliferation and apoptosis of HCC cells to regulate the quantitative changes of HCC, and stimulate the related invasive migratory ability and cell stemness of HCC cells. The present review aims to identify immunotherapeutic options based on the mechanisms of TAMs in the TME of HCC.
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Copy and paste a formatted citation
Spandidos Publications style
Yu M, Yu H, Wang H, Xu X, Sun Z, Chen W, Yu M, Liu C, Jiang M, Zhang X, Zhang X, et al: Tumor‑associated macrophages activated in the tumor environment of hepatocellular carcinoma: Characterization and treatment (Review). Int J Oncol 65: 100, 2024.
APA
Yu, M., Yu, H., Wang, H., Xu, X., Sun, Z., Chen, W. ... Zhang, X. (2024). Tumor‑associated macrophages activated in the tumor environment of hepatocellular carcinoma: Characterization and treatment (Review). International Journal of Oncology, 65, 100. https://doi.org/10.3892/ijo.2024.5688
MLA
Yu, M., Yu, H., Wang, H., Xu, X., Sun, Z., Chen, W., Yu, M., Liu, C., Jiang, M., Zhang, X."Tumor‑associated macrophages activated in the tumor environment of hepatocellular carcinoma: Characterization and treatment (Review)". International Journal of Oncology 65.4 (2024): 100.
Chicago
Yu, M., Yu, H., Wang, H., Xu, X., Sun, Z., Chen, W., Yu, M., Liu, C., Jiang, M., Zhang, X."Tumor‑associated macrophages activated in the tumor environment of hepatocellular carcinoma: Characterization and treatment (Review)". International Journal of Oncology 65, no. 4 (2024): 100. https://doi.org/10.3892/ijo.2024.5688
Copy and paste a formatted citation
x
Spandidos Publications style
Yu M, Yu H, Wang H, Xu X, Sun Z, Chen W, Yu M, Liu C, Jiang M, Zhang X, Zhang X, et al: Tumor‑associated macrophages activated in the tumor environment of hepatocellular carcinoma: Characterization and treatment (Review). Int J Oncol 65: 100, 2024.
APA
Yu, M., Yu, H., Wang, H., Xu, X., Sun, Z., Chen, W. ... Zhang, X. (2024). Tumor‑associated macrophages activated in the tumor environment of hepatocellular carcinoma: Characterization and treatment (Review). International Journal of Oncology, 65, 100. https://doi.org/10.3892/ijo.2024.5688
MLA
Yu, M., Yu, H., Wang, H., Xu, X., Sun, Z., Chen, W., Yu, M., Liu, C., Jiang, M., Zhang, X."Tumor‑associated macrophages activated in the tumor environment of hepatocellular carcinoma: Characterization and treatment (Review)". International Journal of Oncology 65.4 (2024): 100.
Chicago
Yu, M., Yu, H., Wang, H., Xu, X., Sun, Z., Chen, W., Yu, M., Liu, C., Jiang, M., Zhang, X."Tumor‑associated macrophages activated in the tumor environment of hepatocellular carcinoma: Characterization and treatment (Review)". International Journal of Oncology 65, no. 4 (2024): 100. https://doi.org/10.3892/ijo.2024.5688
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