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Non‑coding RNA‑mediated epigenetic modification of ferroptosis in non‑small cell lung cancer (Review)

  • Authors:
    • Yumin Wang
    • Joshua S. Fleishman
    • Yulin Li
    • Yuwei Cao
    • Haidong Wei
    • Zhe Zhang
    • Jichao Chen
    • Mingchao Ding
  • View Affiliations / Copyright

    Affiliations: Department of Respiratory and Critical Care Medicine, Aerospace Center Hospital, Peking University Aerospace School of Clinical Medicine, Beijing 100049, P.R. China, Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, St. John's University, New York, NY 11439, USA, Department of Emergency, Aerospace Center Hospital, Peking University Aerospace School of Clinical Medicine, Beijing 100049, P.R. China, Department of Peripheral Vascular Intervention, Aerospace Center Hospital, Peking University Aerospace School of Clinical Medicine, Beijing, Beijing 100049, P.R. China
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 8
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    Published online on: December 9, 2024
       https://doi.org/10.3892/ijo.2024.5714
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Abstract

Ferroptosis is a novel form of regulated cell death that plays a key role in inhibiting tumor malignancy. The ferroptosis signalling cascade provides new opportunities for lung cancer therapy. Non‑coding RNA (ncRNA)‑mediated epigenetic modification can influence the vulnerability of cancer cells to ferroptosis in non‑small‑cell lung cancer (NSCLC). The present review describes the core molecular mechanisms underlying ferroptosis and the role of epigenetic mechanisms in regulating ferroptosis in NSCLC, as well as developments in understanding the ncRNA‑induced mechanisms that affect ferroptosis in NSCLC. The present review aimed to enhance understanding of the epigenetic mechanisms mediated by ncRNAs that modulate ferroptosis in NSCLC, highlighting a novel therapeutic strategy for NSCLC via the ncRNA‑ferroptosis axis.
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Copy and paste a formatted citation
Spandidos Publications style
Wang Y, Fleishman JS, Li Y, Cao Y, Wei H, Zhang Z, Chen J and Ding M: Non‑coding RNA‑mediated epigenetic modification of ferroptosis in non‑small cell lung cancer (Review). Int J Oncol 66: 8, 2025.
APA
Wang, Y., Fleishman, J.S., Li, Y., Cao, Y., Wei, H., Zhang, Z. ... Ding, M. (2025). Non‑coding RNA‑mediated epigenetic modification of ferroptosis in non‑small cell lung cancer (Review). International Journal of Oncology, 66, 8. https://doi.org/10.3892/ijo.2024.5714
MLA
Wang, Y., Fleishman, J. S., Li, Y., Cao, Y., Wei, H., Zhang, Z., Chen, J., Ding, M."Non‑coding RNA‑mediated epigenetic modification of ferroptosis in non‑small cell lung cancer (Review)". International Journal of Oncology 66.1 (2025): 8.
Chicago
Wang, Y., Fleishman, J. S., Li, Y., Cao, Y., Wei, H., Zhang, Z., Chen, J., Ding, M."Non‑coding RNA‑mediated epigenetic modification of ferroptosis in non‑small cell lung cancer (Review)". International Journal of Oncology 66, no. 1 (2025): 8. https://doi.org/10.3892/ijo.2024.5714
Copy and paste a formatted citation
x
Spandidos Publications style
Wang Y, Fleishman JS, Li Y, Cao Y, Wei H, Zhang Z, Chen J and Ding M: Non‑coding RNA‑mediated epigenetic modification of ferroptosis in non‑small cell lung cancer (Review). Int J Oncol 66: 8, 2025.
APA
Wang, Y., Fleishman, J.S., Li, Y., Cao, Y., Wei, H., Zhang, Z. ... Ding, M. (2025). Non‑coding RNA‑mediated epigenetic modification of ferroptosis in non‑small cell lung cancer (Review). International Journal of Oncology, 66, 8. https://doi.org/10.3892/ijo.2024.5714
MLA
Wang, Y., Fleishman, J. S., Li, Y., Cao, Y., Wei, H., Zhang, Z., Chen, J., Ding, M."Non‑coding RNA‑mediated epigenetic modification of ferroptosis in non‑small cell lung cancer (Review)". International Journal of Oncology 66.1 (2025): 8.
Chicago
Wang, Y., Fleishman, J. S., Li, Y., Cao, Y., Wei, H., Zhang, Z., Chen, J., Ding, M."Non‑coding RNA‑mediated epigenetic modification of ferroptosis in non‑small cell lung cancer (Review)". International Journal of Oncology 66, no. 1 (2025): 8. https://doi.org/10.3892/ijo.2024.5714
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