|
1
|
Palumbo A and Anderson K: Multiple
myeloma. N Engl J Med. 364:1046–1060. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
2
|
Slovak ML: Multiple myeloma: Current
perspectives. Clin Lab Med. 31:699–724. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
3
|
Chauhan D, Uchiyama H, Akbarali Y,
Urashima M, Yamamoto K, Libermann TA and Anderson KC: Multiple
myeloma cell adhesion-induced interleukin-6 expression in bone
marrow stromal cells involves activation of NF-kappa B. Blood.
87:1104–1112. 1996. View Article : Google Scholar : PubMed/NCBI
|
|
4
|
Neri P, Ren L, Azab AK, Brentnall M,
Gratton K, Klimowicz AC, Lin C, Duggan P, Tassone P, Mansoor A, et
al: Integrin β7-mediated regulation of multiple myeloma cell
adhesion, migration, and invasion. Blood. 117:6202–6213. 2011.
View Article : Google Scholar : PubMed/NCBI
|
|
5
|
Xu L, Mohammad KS, Wu H, Crean C, Poteat
B, Cheng Y, Cardoso AA, Machal C, Hanenberg H, Abonour R, et al:
Cell adhesion molecule CD166 drives malignant progression and
osteolytic disease in multiple myeloma. Cancer Res. 76:6901–6910.
2016. View Article : Google Scholar : PubMed/NCBI
|
|
6
|
Kinzel B, Pikiolek M, Orsini V, Sprunger
J, Isken A, Zietzling S, Desplanches M, Dubost V, Breustedt D,
Valdez R, et al: Functional roles of Lgr4 and Lgr5 in embryonic
gut, kidney and skin development in mice. Dev. Biol. 390:181–190.
2014. View Article : Google Scholar : PubMed/NCBI
|
|
7
|
Mao B, Huang S, Lu X, Sun W, Zhou Y, Pan
X, Yu J, Lai M, Chen B, Zhou Q, et al: Early development of
definitive erythroblasts from human pluripotent stem cells defined
by expression of glycophorin A/CD235a, CD34, and CD36. Stem Cell
Reports. 7:869–883. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
8
|
Luo J, Yang Z, Ma Y, Yue Z, Lin H, Qu G,
Huang J, Dai W, Li C, Zheng C, et al: LGR4 is a receptor for RANKL
and negatively regulates osteoclast differentiation and bone
resorption. Nat Med. 22:539–546. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
9
|
Wang Y, Wang H, Guo J, Gao J, Wang M, Xia
M, Wen Y, Su P, Yang M, Liu M, et al: LGR4, Not LGR5, enhances hPSC
hematopoiesis by facilitating mesoderm induction via TGF-Beta
signaling activation. Cell Rep. 31:1076002020. View Article : Google Scholar : PubMed/NCBI
|
|
10
|
Weng J, Luo J, Cheng X, Jin C, Zhou X, Qu
J, Tu L, Ai D, Li D, Wang J, et al: Deletion of G protein-coupled
receptor 48 leads to ocular anterior segment dysgenesis (ASD)
through down-regulation of Pitx2. Proc Natl Acad Sci USA.
105:6081–6086. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
11
|
Luo W, Rodriguez M, Valdez JM, Zhu X, Tan
K, Li D, Siwko S, Xin L and Liu M: Lgr4 is a key regulator of
prostate development and prostate stem cell differentiation. Stem
Cells. 31:2492–2505. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
12
|
Wang J, Liu R, Wang F, Hong J, Li X, Chen
M, Ke Y, Zhang X, Ma Q, Wang R, et al: Ablation of LGR4 promotes
energy expenditure by driving white-to-brown fat switch. Nat Cell
Biol. 15:1455–1463. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
13
|
Wu J, Xie N, Xie K, Zeng J, Cheng L, Lei
Y, Liu Y, Song L, Dong D, Chen Y, et al: GPR48, a poor prognostic
factor, promotes tumor metastasis and activates β-catenin/TCF
signaling in colorectal cancer. Carcinogenesis. 34:2861–2869. 2013.
View Article : Google Scholar : PubMed/NCBI
|
|
14
|
Zheng H, Liu J, Cheng Q, Zhang Q, Zhang Y,
Jiang L, Huang Y, Li W, Zhao Y, Chen G, et al: Targeted activation
of ferroptosis in colorectal cancer via LGR4 targeting overcomes
acquired drug resistance. Nat Cancer. 5:572–589. 2024. View Article : Google Scholar : PubMed/NCBI
|
|
15
|
Yue Z, Niu X, Yuan Z, Qin Q, Jiang W, He
L, Gao J, Ding Y, Liu Y, Xu Z, et al: RSPO2 and RANKL signal
through LGR4 to regulate osteoclastic premetastatic niche formation
and bone metastasis. J Clin Invest. 132:e1445792022. View Article : Google Scholar :
|
|
16
|
van Andel H, Ren Z, Koopmans I, Joosten
SP, Kocemba KA, de Lau W, Kersten MJ, de Bruin AM, Guikema JE,
Clevers H, et al: Aberrantly expressed LGR4 empowers Wnt signaling
in multiple myeloma by hijacking osteoblast-derived R-spondins.
Proc Natl Acad Sci USA. 114:376–381. 2017. View Article : Google Scholar :
|
|
17
|
Yi Z, Ma T, Liu J, Tie W, Li Y, Bai J, Li
L and Zhang L: LGR4 promotes tumorigenesis by activating
TGF-β1/Smad signaling pathway in multiple myeloma. Cell Signal.
110:1108142023. View Article : Google Scholar
|
|
18
|
Huang X, Guo B, Liu S, Wan J and Broxmeyer
HE: Neutralizing negative epigenetic regulation by HDAC5 enhances
human haematopoietic stem cell homing and engraftment. Nat Commun.
9:27412018. View Article : Google Scholar : PubMed/NCBI
|
|
19
|
Rajkumar SV, Dimopoulos MA, Palumbo A,
Blade J, Merlini G, Mateos MV, Kumar S, Hillengass J, Kastritis E,
Richardson P, et al: International Myeloma Working Group updated
criteria for the diagnosis of multiple myeloma. Lancet Oncol.
15:e538–e548. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
20
|
Zhang J, Shi F, Liu X, Wu X, Hu C, Guo J,
Yang Q, Xia J, He Y, An G, et al: Proline promotes proliferation
and drug resistance of multiple myeloma by downregulation of
proline dehydrogenase. Br J Haematol. 201:704–717. 2023. View Article : Google Scholar : PubMed/NCBI
|
|
21
|
Noborio-Hatano K, Kikuchi J, Takatoku M,
Shimizu R, Wada T, Ueda M, Nobuyoshi M, Oh I, Sato K, Suzuki T, et
al: Bortezomib overcomes cell-adhesion-mediated drug resistance
through downregulation of VLA-4 expression in multiple myeloma.
Oncogene. 28:231–242. 2009. View Article : Google Scholar
|
|
22
|
Xia J, Zhang J, Wu X, Du W, Zhu Y, Liu X,
Liu Z, Meng B, Guo J, Yang Q, et al: Blocking glycine utilization
inhibits multiple myeloma progression by disrupting glutathione
balance. Nat Commun. 13:40072022. View Article : Google Scholar : PubMed/NCBI
|
|
23
|
Tu Q, Liu C, Wu D, Wen Y, Wang H, Su P,
Liu Y Ma F, Shi L and Zhou J: Establishment of the screening model
for highly efficient generation of megakaryocytes and platelets
from human pluripotent stem cells (in Chinese). Sci Sin Vitae.
47:1363–1374. 2017. View Article : Google Scholar
|
|
24
|
Wu T, Hu E, Xu S, Chen M, Guo P, Dai Z,
Feng T, Zhou L, Tang W, Zhan L, et al: clusterProfiler 4.0: A
universal enrichment tool for interpreting omics data. Innovation
(Camb). 2:1001412021.PubMed/NCBI
|
|
25
|
Zhou W, Yang Y, Xia J, Wang H, Salama ME,
Xiong W, Xu H, Shetty S, Chen T, Zeng Z, et al: NEK2 induces drug
resistance mainly through activation of efflux drug pumps and is
associated with poor prognosis in myeloma and other cancers. Cancer
Cell. 23:48–62. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
26
|
Takeyama Y, Sato M, Horio M, Hase T,
Yoshida K, Yokoyama T, Nakashima H, Hashimoto N, Sekido Y, Gazdar
AF, et al: Knockdown of ZEB1, a master epithelial-to-mesenchymal
transition (EMT) gene, suppresses anchorage-independent cell growth
of lung cancer cells. Cancer Lett. 296:216–224. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
27
|
Cui H, Li Z, Chen S, Li X, Chen D, Wang J,
Li Z, Hao W, Zhong F, Zhang K, et al: CXCL12/CXCR4-Rac1-mediated
migration of osteogenic precursor cells contributes to pathological
new bone formation in ankylosing spondylitis. Sci Adv.
8:eabl80542022. View Article : Google Scholar : PubMed/NCBI
|
|
28
|
Hu Y, Zhang Y, Ni CY, Chen CY, Rao SS, Yin
H, Huang J, Tan YJ, Wang ZX, Cao J, et al: Human umbilical cord
mesenchymal stromal cells-derived extracellular vesicles exert
potent bone protective effects by CLEC11A-mediated regulation of
bone metabolism. Theranostics. 10:2293–2308. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
29
|
Holt RU, Baykov V, Rø TB, Brabrand S,
Waage A, Sundan A and Børset M: Human myeloma cells adhere to
fibronectin in response to hepatocyte growth factor. Haematologica.
90:479–488. 2005.PubMed/NCBI
|
|
30
|
Gazitt Y, Fey V, Thomas C and Alvarez R:
Bcl-2 overexpression is associated with resistance to
dexamethasone, but not melphalan, in multiple myeloma cells. Int J
Oncol. 13:397–405. 1998.PubMed/NCBI
|
|
31
|
Bianchi G, Czarnecki PG, Ho M, Roccaro AM,
Sacco A, Kawano Y, Gullà A, Samur AA, Chen T, Wen K, et al: ROBO1
promotes homing, dissemination, and survival of multiple myeloma
within the bone marrow microenvironment. Blood Cancer Discov.
2:338–353. 2021. View Article : Google Scholar : PubMed/NCBI
|
|
32
|
Lai S, Cheng R, Gao D, Chen YG and Deng C:
LGR5 constitutively activates NF-κB signaling to regulate the
growth of intestinal crypts. FASEB J. 34:15605–15620. 2020.
View Article : Google Scholar : PubMed/NCBI
|
|
33
|
Wizenty J, Müllerke S, Kolesnichenko M,
Heuberger J, Lin M, Fischer AS, Mollenkopf HJ, Berger H, Tacke F
and Sigal M: Gastric stem cells promote inflammation and gland
remodeling in response to Helicobacter pylori via Rspo3-Lgr4 axis.
EMBO J. 41:e1099962022. View Article : Google Scholar : PubMed/NCBI
|
|
34
|
Takeuchi M and Baichwal VR: Induction of
the gene encoding mucosal vascular addressin cell adhesion molecule
1 by tumor necrosis factor alpha is mediated by NF-kappa B
proteins. Proc Natl Acad Sci USA. 92:3561–3565. 1995. View Article : Google Scholar : PubMed/NCBI
|
|
35
|
O'Shea JM and Perkins ND: Thr435
phosphorylation regulates RelA (p65) NF-kappaB subunit
transactivation. Biochem J. 426:345–354. 2010. View Article : Google Scholar
|
|
36
|
Perkins ND: The diverse and complex roles
of NF-κB subunits in cancer. Nat Rev Cancer. 12:121–132. 2012.
View Article : Google Scholar : PubMed/NCBI
|
|
37
|
Gong X, Yi J, Carmon KS, Crumbley CA,
Xiong W, Thomas A, Fan X, Guo S, An Z, Chang JT and Liu QJ:
Aberrant RSPO3-LGR4 signaling in Keap1-deficient lung
adenocarcinomas promotes tumor aggressiveness. Oncogene.
34:4692–4701. 2015. View Article : Google Scholar :
|
|
38
|
Yue F, Jiang W, Ku AT, Young AIJ, Zhang W,
Souto EP, Gao Y, Yu Z, Wang Y, Creighton CJ, et al: A
Wnt-independent LGR4-EGFR signaling axis in cancer metastasis.
Cancer Res. 81:4441–4454. 2021. View Article : Google Scholar : PubMed/NCBI
|
|
39
|
Salik B, Yi H, Hassan N, Santiappillai N,
Vick B, Connerty P, Duly A, Trahair T, Woo AJ, Beck D, et al:
Targeting RSPO3-LGR4 signaling for leukemia stem cell eradication
in acute myeloid leukemia. Cancer Cell. 38:263–278.e6. 2020.
View Article : Google Scholar : PubMed/NCBI
|
|
40
|
Mitchell JS, Li N, Weinhold N, Försti A,
Ali M, van Duin M, Thorleifsson G, Johnson DC, Chen B, Halvarsson
BM, et al: Genome-wide association study identifies multiple
susceptibility loci for multiple myeloma. Nat Commun. 7:120502016.
View Article : Google Scholar : PubMed/NCBI
|
|
41
|
Stevens PD and Williams BO: LGR4: Not just
for Wnt anymore? Cancer Res. 81:4397–4398. 2021. View Article : Google Scholar : PubMed/NCBI
|
|
42
|
Cowan AJ, Green DJ, Kwok M, Lee S, Coffey
DG, Holmberg LA, Tuazon S, Gopal AK and Libby EN: Diagnosis and
management of multiple myeloma: A review. JAMA. 327:464–477. 2022.
View Article : Google Scholar : PubMed/NCBI
|
