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Long non‑coding RNA ABHD11‑AS1 inhibits colorectal cancer progression through interacting with EGFR to suppress the EGFR/ERK signaling pathway

  • Authors:
    • Shiming Tan
    • Shizhen Li
    • Longzheng Xia
    • Xianjie Jiang
    • Zongyao Ren
    • Qiu Peng
    • Mingjing Peng
    • Wenjuan Yang
    • Xuemeng Xu
    • Linda Oyang
    • Mengzhou Shen
    • Jiewen Wang
    • Haofan Li
    • Nayiyuan Wu
    • Yanyan Tang
    • Qianjin Liao
    • Jinguan Lin
    • Yujuan Zhou
  • View Affiliations / Copyright

    Affiliations: The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University/Hunan Cancer Hospital, Hunan Key Laboratory of Cancer Metabolism, Changsha, Hunan 410013, P.R. China, Department of Oncology, Hunan Provincial People's Hospital (The First Affiliated Hospital of Hunan Normal University), Changsha, Hunan 410005, P.R. China
    Copyright: © Tan et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 20
    |
    Published online on: February 11, 2025
       https://doi.org/10.3892/ijo.2025.5726
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Abstract

Long non‑coding (lnc)RNAs participate in colorectal cancer (CRC) occurrence and progression. The present study aimed to investigate whether lncRNA ABHD11‑AS1 regulates malignant biological behavior of CRC cells. Bioinformatic analysis, reverse transcription‑quantitative PCR and in situ hybridization revealed that ABHD11‑AS1 expression was decreased in CRC samples and associated with an unfavorable prognosis. ABHD11‑AS1 overexpression significantly decreased proliferation, migration and invasion of CRC cells, whereas ABHD11‑AS1 inhibition had the opposite effects. ABHD11‑AS1 interacted with EGFR to inhibit EGFR phosphorylation and attenuate EGFR/ERK signaling, which in turn suppressed the malignant biological behavior of CRC cells. The tumor suppressor function of ABHD11‑AS1 was attenuated by the EGFR agonist NSC228155. Finally, resveratrol (RSV) inhibited CRC cell proliferation, migration and invasion, which may be associated with RSV‑induced decrease in SPT6 homolog, histone chaperone and transcription elongation factor protein expression and increase in ABHD11‑AS1 transcript levels. ABHD11‑AS1 inhibited the phosphorylation of EGFR and decreased EGFR/ERK signaling by interacting with EGFR, thereby delaying the progression of CRC. The ABHD11‑AS1/EGFR/ERK axis may be a novel therapeutic target for preventing CRC progression.
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Tan S, Li S, Xia L, Jiang X, Ren Z, Peng Q, Peng M, Yang W, Xu X, Oyang L, Oyang L, et al: Long non‑coding RNA ABHD11‑AS1 inhibits colorectal cancer progression through interacting with EGFR to suppress the EGFR/ERK signaling pathway. Int J Oncol 66: 20, 2025.
APA
Tan, S., Li, S., Xia, L., Jiang, X., Ren, Z., Peng, Q. ... Zhou, Y. (2025). Long non‑coding RNA ABHD11‑AS1 inhibits colorectal cancer progression through interacting with EGFR to suppress the EGFR/ERK signaling pathway. International Journal of Oncology, 66, 20. https://doi.org/10.3892/ijo.2025.5726
MLA
Tan, S., Li, S., Xia, L., Jiang, X., Ren, Z., Peng, Q., Peng, M., Yang, W., Xu, X., Oyang, L., Shen, M., Wang, J., Li, H., Wu, N., Tang, Y., Liao, Q., Lin, J., Zhou, Y."Long non‑coding RNA ABHD11‑AS1 inhibits colorectal cancer progression through interacting with EGFR to suppress the EGFR/ERK signaling pathway". International Journal of Oncology 66.3 (2025): 20.
Chicago
Tan, S., Li, S., Xia, L., Jiang, X., Ren, Z., Peng, Q., Peng, M., Yang, W., Xu, X., Oyang, L., Shen, M., Wang, J., Li, H., Wu, N., Tang, Y., Liao, Q., Lin, J., Zhou, Y."Long non‑coding RNA ABHD11‑AS1 inhibits colorectal cancer progression through interacting with EGFR to suppress the EGFR/ERK signaling pathway". International Journal of Oncology 66, no. 3 (2025): 20. https://doi.org/10.3892/ijo.2025.5726
Copy and paste a formatted citation
x
Spandidos Publications style
Tan S, Li S, Xia L, Jiang X, Ren Z, Peng Q, Peng M, Yang W, Xu X, Oyang L, Oyang L, et al: Long non‑coding RNA ABHD11‑AS1 inhibits colorectal cancer progression through interacting with EGFR to suppress the EGFR/ERK signaling pathway. Int J Oncol 66: 20, 2025.
APA
Tan, S., Li, S., Xia, L., Jiang, X., Ren, Z., Peng, Q. ... Zhou, Y. (2025). Long non‑coding RNA ABHD11‑AS1 inhibits colorectal cancer progression through interacting with EGFR to suppress the EGFR/ERK signaling pathway. International Journal of Oncology, 66, 20. https://doi.org/10.3892/ijo.2025.5726
MLA
Tan, S., Li, S., Xia, L., Jiang, X., Ren, Z., Peng, Q., Peng, M., Yang, W., Xu, X., Oyang, L., Shen, M., Wang, J., Li, H., Wu, N., Tang, Y., Liao, Q., Lin, J., Zhou, Y."Long non‑coding RNA ABHD11‑AS1 inhibits colorectal cancer progression through interacting with EGFR to suppress the EGFR/ERK signaling pathway". International Journal of Oncology 66.3 (2025): 20.
Chicago
Tan, S., Li, S., Xia, L., Jiang, X., Ren, Z., Peng, Q., Peng, M., Yang, W., Xu, X., Oyang, L., Shen, M., Wang, J., Li, H., Wu, N., Tang, Y., Liao, Q., Lin, J., Zhou, Y."Long non‑coding RNA ABHD11‑AS1 inhibits colorectal cancer progression through interacting with EGFR to suppress the EGFR/ERK signaling pathway". International Journal of Oncology 66, no. 3 (2025): 20. https://doi.org/10.3892/ijo.2025.5726
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