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Review Open Access

Epigenetic and epitranscriptomic role of lncRNA in carcinogenesis (Review)

  • Authors:
    • Chunfei Dai
    • Haoyue Qianjiang
    • Ruishuang Fu
    • Huimin Yang
    • Aiqin Shi
    • Huacheng Luo
  • View Affiliations / Copyright

    Affiliations: Zhejiang Cancer Hospital, The Key Laboratory of Zhejiang Province for Aptamers and Theranostics, Hangzhou Institute of Medicine, The Chinese Academy of Sciences, Hangzhou, Zhejiang 310022, P.R. China, Xianghu Laboratory, Hangzhou, Zhejiang 311231, P.R. China
    Copyright: © Dai et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 29
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    Published online on: February 26, 2025
       https://doi.org/10.3892/ijo.2025.5735
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Abstract

Long non‑coding RNAs (lncRNAs) are key players in the regulation of gene expression by mediating epigenetic and epitranscriptomic modification. Dysregulation of lncRNAs is implicated in tumor initiation, progression and metastasis. lncRNAs modulate chromatin structure and gene transcription by recruiting epigenetic regulators, including DNA‑ or histone‑modifying enzymes. Additionally, lncRNAs mediate chromatin remodeling and enhancer‑promoter long‑range chromatin interactions to control oncogene expression by recruiting chromatin organization‑associated proteins, thereby promoting carcinogenesis. Furthermore, lncRNAs aberrantly induce oncogene expression by mediating epitranscriptomic modifications, including RNA methylation and RNA editing. The present study aimed to summarize the regulatory mechanisms of lncRNAs in cancer to unravel the complex interplay between lncRNAs and epigenetic/epitranscriptomic regulators in carcinogenesis. The present review aimed to provide a novel perspective on the epigenetic and epitranscriptomic roles of lncRNAs in carcinogenesis to facilitate identification of potential biomarkers and therapeutic targets for cancer diagnosis and treatment.
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Spandidos Publications style
Dai C, Qianjiang H, Fu R, Yang H, Shi A and Luo H: Epigenetic and epitranscriptomic role of lncRNA in carcinogenesis (Review). Int J Oncol 66: 29, 2025.
APA
Dai, C., Qianjiang, H., Fu, R., Yang, H., Shi, A., & Luo, H. (2025). Epigenetic and epitranscriptomic role of lncRNA in carcinogenesis (Review). International Journal of Oncology, 66, 29. https://doi.org/10.3892/ijo.2025.5735
MLA
Dai, C., Qianjiang, H., Fu, R., Yang, H., Shi, A., Luo, H."Epigenetic and epitranscriptomic role of lncRNA in carcinogenesis (Review)". International Journal of Oncology 66.4 (2025): 29.
Chicago
Dai, C., Qianjiang, H., Fu, R., Yang, H., Shi, A., Luo, H."Epigenetic and epitranscriptomic role of lncRNA in carcinogenesis (Review)". International Journal of Oncology 66, no. 4 (2025): 29. https://doi.org/10.3892/ijo.2025.5735
Copy and paste a formatted citation
x
Spandidos Publications style
Dai C, Qianjiang H, Fu R, Yang H, Shi A and Luo H: Epigenetic and epitranscriptomic role of lncRNA in carcinogenesis (Review). Int J Oncol 66: 29, 2025.
APA
Dai, C., Qianjiang, H., Fu, R., Yang, H., Shi, A., & Luo, H. (2025). Epigenetic and epitranscriptomic role of lncRNA in carcinogenesis (Review). International Journal of Oncology, 66, 29. https://doi.org/10.3892/ijo.2025.5735
MLA
Dai, C., Qianjiang, H., Fu, R., Yang, H., Shi, A., Luo, H."Epigenetic and epitranscriptomic role of lncRNA in carcinogenesis (Review)". International Journal of Oncology 66.4 (2025): 29.
Chicago
Dai, C., Qianjiang, H., Fu, R., Yang, H., Shi, A., Luo, H."Epigenetic and epitranscriptomic role of lncRNA in carcinogenesis (Review)". International Journal of Oncology 66, no. 4 (2025): 29. https://doi.org/10.3892/ijo.2025.5735
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