[Corrigendum] Dual targeting of glioblastoma multiforme with a proteasome inhibitor (Velcade) and a phosphatidylinositol 3‑kinase inhibitor (ZSTK474)

Lin,Lehang; Gaut,Daria; Hu,Kaishun; Yan,Haiyan; Yin,Dong; Koeffler,Phillip H.

doi:10.3892/ijo.2025.5777

September-2025 Volume 67 Issue 3

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International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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September-2025 Volume 67 Issue 3

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Correction Open Access

[Corrigendum] Dual targeting of glioblastoma multiforme with a proteasome inhibitor (Velcade) and a phosphatidylinositol 3‑kinase inhibitor (ZSTK474)

Authors:
- Lehang Lin
- Daria Gaut
- Kaishun Hu
- Haiyan Yan
- Dong Yin
- Phillip H. Koeffler
View Affiliations / Copyright

Affiliations: Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Medical Research Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou 510120, P.R. China, Division of Hematology/Oncology, Cedars-Sinai Medical Center, UCLA School of Medicine, Los Angeles, CA 90048, USA

Copyright: © Lin et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY 4.0].
Article Number: 71
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Published online on: July 16, 2025

https://doi.org/10.3892/ijo.2025.5777
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Int J Oncol 44: [Related article:] 557-562, 2014; DOI: 10.3892/ijo.2013.2205

Following the publication of the above article, an interested reader drew to the attention of the Editorial Office that GAPDH bands featured for the U87 cell line (left-hand panels) in Fig. 5 on p. 561 were strikingly similar to the GAPDH bands for the U118 cell line (right-hand panels) shown in Fig. 1 on p. 559, even though the experiments shown in these figures were performed under different experimental conditions. Upon examining their data, the authors have realized that Fig. 5 was presented incorrectly; specifically, the cell lines ('U87' and 'U118') in Fig. 5 were mistakenly labeled in reverse, and the GAPDH bands from the right-hand panels of Fig. 1 were inadvertently re-used in the left-hand panels of Fig. 5.

Figure 5

Effects of Velcade and ZSTK474 on the expression of apoptotic-related protein PARP in GBM cell lines. U118 and U87 cells were cultured for 24 h with Velcade (100 nM), ZSTK474 (2.5 μM), or both simultaneously. Lysates were made and subjected to western blot analysis for poly(ADP-ribose) polymerase (PARP), generating a C-terminal 85-kDa apoptotic fragment when cells were treated with both drugs (arrow).

The authors have now corrected the cell line labels and replaced the GAPDH bands in the left-hand panels of Fig. 5 with alternative data from a repeated experiment. The revised version of Fig. 5 is shown below. It is important to note that this error did not affect the overall conclusions reported in the study. The authors are grateful to the Editor of International Journal of Oncology for allowing them this opportunity to publish a Corrigendum, and all the authors agree with its publication. Furthermore, the authors deeply apologize to the readership for any inconvenience caused.

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

[Corrigendum] Dual targeting of glioblastoma multiforme with a proteasome inhibitor (Velcade) and a phosphatidylinositol 3‑kinase inhibitor (ZSTK474)

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