[Corrigendum] Identification of Akt1 as a potent therapeutic target for oral squamous cell carcinoma

Nakashiro,Koh-Ichi; Tanaka,Hiroshi; Goda,Hiroyuki; Iwamoto,Kazuki; Tokuzen,Norihiko; Hara,Shingo; Onodera,Jun; Hino,Satoshi; Hamakawa,Hiroyuki

doi:10.3892/ijo.2025.5790

October-2025 Volume 67 Issue 4

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Correction Open Access

[Corrigendum] Identification of Akt1 as a potent therapeutic target for oral squamous cell carcinoma

Authors:
- Koh-Ichi Nakashiro
- Hiroshi Tanaka
- Hiroyuki Goda
- Kazuki Iwamoto
- Norihiko Tokuzen
- Shingo Hara
- Jun Onodera
- Satoshi Hino
- Hiroyuki Hamakawa
View Affiliations / Copyright

Affiliations: Department of Oral and Maxillofacial Surgery, Ehime University Graduate School of Medicine, Toon, Ehime 791-0295, Japan, Department of Oral and Maxillofacial Surgery, Kochi Health Sciences Center, Kochi 781-8555, Japan, Koken Research Institute, Koken Co., Ltd., Tokyo 102-0081, Japan

Copyright: © Nakashiro et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY 4.0].
Article Number: 84
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Published online on: August 19, 2025

https://doi.org/10.3892/ijo.2025.5790
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Int J Oncol 47: [Related article:] 1273-1281, 2015; DOI: 10.3892/ijo.2015.3134

Following the publication of the above paper, it was drawn to the Editor's attention by a concerned reader that, regarding the western blots shown in Figs. 1C and 3A, the six lanes for the control β-tubulin blots shown in Fig. 1C appeared strikingly similar to the β-tubulin blots in Fig. 3A, albeit the bands in Fig. 3A appeared to have been horizontally stretched.

Figure 3

Effects of Akt1 knockdown in the human OSCC cell line, GFP-SAS. (A) Five siAkt1 constructs (siAkt1-6, siAkt1-22, siAkt1-33, siAkt1-56, and siAkt1-58) were transfected into cells at 10 nM with Lipofectamine RNAiMAX. The effects on Akt1 protein expression were evaluated by western blotting and showed that all siAkt1 constructs suppressed expression. (B) The effects of siAkt1-22 and 58 on cell growth were assessed in cells seeded in complete medium and both siRNA constructs significantly inhibited cell growth. (C) The effects of siAkt1-22 and 58 on the invasive growth were examined in the collagen gel culture system and they significantly suppressed the invasive growth. *p<0.01 compared to control cultures transfected with siGFP.

The authors were able to check their original data, and realized that Fig. 3 had inadvertently been assembled incorrectly. A revised version of Fig. 3, now showing data for both the Akt1 and β-tubulin blots from one of the repeated experiments, is shown opposite. All authors confirm that the errors made in assembling Fig. 3 did not have a major impact on the conclusions reported in the above article, and they thank the Editor of International Journal of Oncology for allowing them the opportunity to publish a Corrigendum. Furthermore, all the authors agree to the publication of this Corrigendum, and apologize to the readers for any inconvenience caused.

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

[Corrigendum] Identification of Akt1 as a potent therapeutic target for oral squamous cell carcinoma

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