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Review

Exosomal microRNAs: A new role in the diagnosis and treatment of lung cancer metastases (Review)

  • Authors:
    • Xin Li
    • Jian Wang
    • Weipeng Ge
    • Xinbo Chen
  • View Affiliations / Copyright

    Affiliations: Department of Pain, Shengli Oilfield Central Hospital, Dongying, Shandong 257000, P.R. China, Department of Oncology, Lijin County Central Hospital, Dongying, Shandong 257400, P.R. China, Department of Gastroenterology, Shengli Oilfield Central Hospital, Dongying, Shandong 257000, P.R. China
  • Article Number: 101
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    Published online on: October 8, 2025
       https://doi.org/10.3892/ijo.2025.5807
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Abstract

Lung cancer (LC) is a lethal malignancy that can pose a serious risk to a patient's health. Tumor metastasis is associated with a shorter survival and poor therapeutic outcomes. Epithelial‑mesenchymal transition, cell proliferation and angiogenesis are the key drivers of metastasis, which accounts for cancer malignancy. Exosomal microRNAs (miRNAs) are miRNAs packed and released in exosomes. Exosomal miRNAs promote the metastasis of LC. As the amount and type of exosomal miRNAs are disrupted in pathological situations, they may serve as markers for the diagnosis and treatment of LC. The present review summarizes the effects and underlying mechanisms of exosomal miRNAs in LC metastasis. It also provides an overview of the potential of exosomal miRNAs as diagnostic indicators and therapeutic targets for LC metastasis, highlighting novel avenues for future tailored therapies.
View Figures

Figure 1

miRNA biogenesis and secretion in
tumor cells. To create primary miRNAs, RNA pol II or pol III
transcribes miRNAs in the nucleus (pri-miRNAs). Pre-miRNAs are
created by separating pri-miRNAs using the DGCR8 complex, after
which they are exported to the cytoplasm by the exportin-5 complex.
To create mature double-stranded miRNAs, the TRBP complex further
separates the pre-miRNAs. The passenger strand of the mature miRNA’
is then degraded, and the guide strand is loaded into the RISC to
control the expression of the target gene. miRNAs, also referred to
as exosomal miRNAs, are transported by exosomes into receptor
cells, enabling non-neighboring cells to communicate with one
another to coordinate immune responses, invasion, migration,
differentiation and antigen presentation. miRNA, microRNA; pol,
polymerase; DGCR8, Drosha/DiGeorge Critical Region 8; TRBP,
Dicer/TAR-RNA binding protein; RISC, RNA-induced silencing complex;
pri-miRNA, primary precursor miRNA; pre-miRNA, precursor miNA.
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Copy and paste a formatted citation
Spandidos Publications style
Li X, Wang J, Ge W and Chen X: Exosomal microRNAs: A new role in the diagnosis and treatment of lung cancer metastases (Review). Int J Oncol 67: 101, 2025.
APA
Li, X., Wang, J., Ge, W., & Chen, X. (2025). Exosomal microRNAs: A new role in the diagnosis and treatment of lung cancer metastases (Review). International Journal of Oncology, 67, 101. https://doi.org/10.3892/ijo.2025.5807
MLA
Li, X., Wang, J., Ge, W., Chen, X."Exosomal microRNAs: A new role in the diagnosis and treatment of lung cancer metastases (Review)". International Journal of Oncology 67.6 (2025): 101.
Chicago
Li, X., Wang, J., Ge, W., Chen, X."Exosomal microRNAs: A new role in the diagnosis and treatment of lung cancer metastases (Review)". International Journal of Oncology 67, no. 6 (2025): 101. https://doi.org/10.3892/ijo.2025.5807
Copy and paste a formatted citation
x
Spandidos Publications style
Li X, Wang J, Ge W and Chen X: Exosomal microRNAs: A new role in the diagnosis and treatment of lung cancer metastases (Review). Int J Oncol 67: 101, 2025.
APA
Li, X., Wang, J., Ge, W., & Chen, X. (2025). Exosomal microRNAs: A new role in the diagnosis and treatment of lung cancer metastases (Review). International Journal of Oncology, 67, 101. https://doi.org/10.3892/ijo.2025.5807
MLA
Li, X., Wang, J., Ge, W., Chen, X."Exosomal microRNAs: A new role in the diagnosis and treatment of lung cancer metastases (Review)". International Journal of Oncology 67.6 (2025): 101.
Chicago
Li, X., Wang, J., Ge, W., Chen, X."Exosomal microRNAs: A new role in the diagnosis and treatment of lung cancer metastases (Review)". International Journal of Oncology 67, no. 6 (2025): 101. https://doi.org/10.3892/ijo.2025.5807
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