[Expression of Concern] Regulation of NADPH oxidase (Nox2) by lipid rafts in breast carcinoma cells

Malla,Rama Rao; Raghu,Hari; Rao,Jasti S.

doi:10.3892/ijo.2025.5814

January-2026 Volume 68 Issue 1

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Expression of Concern Open Access

[Expression of Concern] Regulation of NADPH oxidase (Nox2) by lipid rafts in breast carcinoma cells

Authors:
- Rama Rao Malla
- Hari Raghu
- Jasti S. Rao
View Affiliations / Copyright

Affiliations: Department of Cancer Biology and Pharmacology, University of Illinois College of Medicine at Peoria, One Illini Drive, Peoria, IL 61605, USA

Copyright: © Malla et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY 4.0].
Article Number: 1
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Published online on: October 23, 2025

https://doi.org/10.3892/ijo.2025.5814
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Abstract

Following the publication of the above paper, a potential problem regarding the presentation of the co‑localization experiments shown in Fig. 5A and C was brought to the Editor's attention by a concerned reader. Specifically, the Flotillin/gp91 co‑localization panels (Fig. 5A) appeared to be unexpectedly similar to the Flotillin/p22 panels (Fig. 5C), even though, according to the Materials and methods section, the different antibody treatments that were reported might have precluded the possibility of these images looking so similar. The authors were contacted by the Editorial Office to offer an explanation for this potential anomaly in the presentation of the data in this paper (or to clarify how the experiments had been performed), although up to this time, no response from them has been forthcoming. Owing to the fact that the Editorial Office has been made aware of potential issues surrounding the scientific integrity of this paper, we are issuing an Expression of Concern to notify readers of this potential problem while the Editorial Office continues to investigate this matter further. [International Journal of Oncology 37: 1483‑1493, 2010; DOI: 10.3892/ijo_00000801]

Int J Oncol 37: [Related article:] 1483-1493, 2010; DOI: 10.3892/ijo_00000801

Following the publication of the above paper, a potential problem regarding the presentation of the co-localization experiments shown in Fig. 5A and C was brought to the Editor's attention by a concerned reader. Specifically, the Flotillin/gp91 co-localization panels (Fig. 5A) appeared to be unexpectedly similar to the Flotillin/p22 panels (Fig. 5C), even though, according to the Materials and methods section, the different antibody treatments that were reported might have precluded the possibility of these images looking so similar.

The authors were contacted by the Editorial Office to offer an explanation for this potential anomaly in the presentation of the data in this paper (or to clarify how the experiments had been performed), although up to this time, no response from them has been forthcoming. Owing to the fact that the Editorial Office has been made aware of potential issues surrounding the scientific integrity of this paper, we are issuing an Expression of Concern to notify readers of this potential problem while the Editorial Office continues to investigate this matter further.

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

[Expression of Concern] Regulation of NADPH oxidase (Nox2) by lipid rafts in breast carcinoma cells

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Abstract

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