[Expression of Concern] MUC1 is a downstream target of STAT3 and regulates lung cancer cell survival and invasion

Gao,Jingchun; Mcconnell,Matthew J.; Yu,Bin; Li,Jiannong; Balko,Justin M.; Black,Esther P.; Johnson,Joseph O.; Lloyd,Mark C.; Altiok,Soner; Haura,Eric B.

doi:10.3892/ijo.2025.5829

February-2026 Volume 68 Issue 2

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February-2026 Volume 68 Issue 2

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Expression of Concern Open Access

[Expression of Concern] MUC1 is a downstream target of STAT3 and regulates lung cancer cell survival and invasion

Authors:
- Jingchun Gao
- Matthew J. Mcconnell
- Bin Yu
- Jiannong Li
- Justin M. Balko
- Esther P. Black
- Joseph O. Johnson
- Mark C. Lloyd
- Soner Altiok
- Eric B. Haura
View Affiliations / Copyright

Affiliations: Department of Thoracic Oncology and Experimental Therapeutics Program, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA, Department of Pharmaceutical Science, University of Kentucky, Lexington, KY 40536, USA, Analytic Microscopy Core, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA

Copyright: © Gao et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY 4.0].
Article Number: 16
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Published online on: December 3, 2025

https://doi.org/10.3892/ijo.2025.5829
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Abstract

Following the publication of the above paper, it was drawn to the Editor's attention by a concerned reader that the Bcl‑2 protein bands shown for the HCC827 cell line in the western blots in Fig. 3A on p. 342 were unexpectedly similar to the Akt protein bands shown for the A549 cell line in Fig. 3B. In addition, the Bcl‑2 protein bands shown for the H358 and HCC827 cell lines (the left‑hand and middle gels) possibly contained a pair of mutually overlapping protein bands, and the β‑actin control bands featured in the left‑hand and middle lanes of Fig. 3A for the H358 and HCC827 cell lines, and the β‑actin control bands featured in the middle and right‑hand lanes for the H358 and HCC827 cell lines in Fig. 1C on p. 340, were similarly more similar than might have been expected. The authors were contacted by the Editorial Office to offer an explanation for this possible anomaly in the presentation of the data in this paper, although up to this time, no response from them has been forthcoming. Owing to the fact that the Editorial Office has been made aware of potential issues surrounding the scientific integrity of this paper, we are issuing an Expression of Concern to notify readers of this potential problem while the Editorial Office continues to investigate this matter further. [International Journal of Oncology 35: 337‑345, 2009; DOI: 10.3892/ijo_00000345]

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

[Expression of Concern] MUC1 is a downstream target of STAT3 and regulates lung cancer cell survival and invasion

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Abstract

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