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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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April-2026 Volume 68 Issue 4

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Molecular and Clinical Oncology

Molecular and Clinical Oncology

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International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

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Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Review Open Access

Role of SPAG6 in regulating physiological functions and tumorigenesis (Review)

  • Authors:
    • Yu Luo
    • Qibing Yan
    • Pohao Zhang
    • Hui Xu
    • Rong Zhang
    • Ruihe Wang
    • Yongkang Wu

  • View Affiliations / Copyright

    Affiliations: Outpatient Department, West China Hospital Sichuan University Jintang Hospital, Jintang First People's Hospital, Chengdu, Sichuan 610400, P.R. China, Clinical Laboratory, West China Hospital Sichuan University Jintang Hospital, Jintang First People's Hospital, Chengdu, Sichuan 610400, P.R. China, Intensive Care Unit, West China Hospital Sichuan University Jintang Hospital, Jintang First People's Hospital, Chengdu, Sichuan 610400, P.R. China, Department of Orthopedics, West China Hospital Sichuan University Jintang Hospital, Jintang First People's Hospital, Chengdu, Sichuan 610400, P.R. China, Department of Neurology, West China Hospital Sichuan University Jintang Hospital, Jintang First People's Hospital, Chengdu, Sichuan 610400, P.R. China
    Copyright: © Luo et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 42
    |
    Published online on: February 12, 2026
       https://doi.org/10.3892/ijo.2026.5855
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Abstract

Sperm‑associated antigen 6 (SPAG6) belongs to the cancer/testis antigen family. It is a microtubule‑binding protein located on chromosome 10p12.2 and it plays an important role in various physiological processes, including ciliary movement, immune synapse formation and neurodevelopment. Abnormal SPAG6 expression occurs in multiple malignancies and developmental disorders; however, its underlying molecular mechanisms in tumorigenesis, tumor progression, clinical outcomes and therapeutic response have not been presented. This review provides a comprehensive overview of the physiological functions of SPAG6 and its mechanisms in disease, with a focus on its expression profile, function and association with disease progression and treatment response in hematologic malignancies (e.g., myelodysplastic syndrome, acute myeloid leukemia and B‑cell acute lymphoblastic leukemia) and solid tumors (e.g., breast cancer, lung cancer and osteosarcoma). SPAG6 promotes tumor progression and drug resistance by attenuating the cell cycle and through epigenetic modifications and remodeling of the tumor immune microenvironment. In addition, it may serve as a diagnostic and prognostic marker for various diseases as well as a therapeutic target.

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Copy and paste a formatted citation
Spandidos Publications style
Luo Y, Yan Q, Zhang P, Xu H, Zhang R, Wang R and Wu Y: <p>Role of SPAG6 in regulating physiological functions and tumorigenesis (Review)</p>. Int J Oncol 68: 42, 2026.
APA
Luo, Y., Yan, Q., Zhang, P., Xu, H., Zhang, R., Wang, R., & Wu, Y. (2026). <p>Role of SPAG6 in regulating physiological functions and tumorigenesis (Review)</p>. International Journal of Oncology, 68, 42. https://doi.org/10.3892/ijo.2026.5855
MLA
Luo, Y., Yan, Q., Zhang, P., Xu, H., Zhang, R., Wang, R., Wu, Y."<p>Role of SPAG6 in regulating physiological functions and tumorigenesis (Review)</p>". International Journal of Oncology 68.4 (2026): 42.
Chicago
Luo, Y., Yan, Q., Zhang, P., Xu, H., Zhang, R., Wang, R., Wu, Y."<p>Role of SPAG6 in regulating physiological functions and tumorigenesis (Review)</p>". International Journal of Oncology 68, no. 4 (2026): 42. https://doi.org/10.3892/ijo.2026.5855
Copy and paste a formatted citation
x
Spandidos Publications style
Luo Y, Yan Q, Zhang P, Xu H, Zhang R, Wang R and Wu Y: <p>Role of SPAG6 in regulating physiological functions and tumorigenesis (Review)</p>. Int J Oncol 68: 42, 2026.
APA
Luo, Y., Yan, Q., Zhang, P., Xu, H., Zhang, R., Wang, R., & Wu, Y. (2026). <p>Role of SPAG6 in regulating physiological functions and tumorigenesis (Review)</p>. International Journal of Oncology, 68, 42. https://doi.org/10.3892/ijo.2026.5855
MLA
Luo, Y., Yan, Q., Zhang, P., Xu, H., Zhang, R., Wang, R., Wu, Y."<p>Role of SPAG6 in regulating physiological functions and tumorigenesis (Review)</p>". International Journal of Oncology 68.4 (2026): 42.
Chicago
Luo, Y., Yan, Q., Zhang, P., Xu, H., Zhang, R., Wang, R., Wu, Y."<p>Role of SPAG6 in regulating physiological functions and tumorigenesis (Review)</p>". International Journal of Oncology 68, no. 4 (2026): 42. https://doi.org/10.3892/ijo.2026.5855
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