|
1
|
Li X, Xu L, Sun G, Wu X, Bai X, Li J,
Strauss JF, Zhang Z and Wang H: Spag6 mutant mice have defects in
development and function of spiral ganglion neurons, apoptosis, and
higher sensitivity to paclitaxel. Sci Rep. 7:86382017. View Article : Google Scholar : PubMed/NCBI
|
|
2
|
Siliņa K, Zayakin P, Kalniņa Z, Ivanova L,
Meistere I, Endzeliņš E, Abols A, Stengrēvics A, Leja M, Ducena K,
et al: Sperm-associated antigens as targets for cancer
immunotherapy: Expression pattern and humoral immune response in
cancer patients. J Immunother. 34:28–44. 2011. View Article : Google Scholar
|
|
3
|
Neilson LI, Schneider PA, Van Deerlin PG,
Kiriakidou M, Driscoll DA, Pellegrini MC, Millinder S, Yamamoto KK,
French CK and Strauss JF III: cDNA cloning and characterization of
a human sperm antigen (SPAG6) with homology to the product of the
Chlamydomonas PF16 locus. Genomics. 60:272–280. 1999. View Article : Google Scholar : PubMed/NCBI
|
|
4
|
Qiu H, Gołas A, Grzmil P and Wojnowski L:
Lineage-specific duplications of Muroidea Faim and Spag6 genes and
atypical accelerated evolution of the parental Spag6 gene. J Mol
Evol. 77:119–129. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
5
|
Tewari R, Bailes E, Bunting KA and Coates
JC: Armadillo-repeat protein functions: Questions for little
creatures. Trends Cell Biol. 20:470–481. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
6
|
Scanlan MJ, Simpson AJ and Old LJ: The
cancer/testis genes: Review, standardization, and commentary.
Cancer Immun. 4:12004.PubMed/NCBI
|
|
7
|
Teves ME, Sears PR, Li W and Zhang Z, Tang
W, van Reesema L, Costanzo RM, Davis CW, Knowles MR, Strauss JF III
and Zhang Z: Sperm-associated antigen 6 (SPAG6) deficiency and
defects in ciliogenesis and cilia function: Polarity, density, and
beat. PLoS One. 9:e1072712014. View Article : Google Scholar : PubMed/NCBI
|
|
8
|
Li W, Mukherjee A, Wu J, Zhang L, Teves
ME, Li H, Nambiar S, Henderson SC, Horwitz AR, Strauss JF III, et
al: Sperm associated antigen 6 (SPAG6) regulates fibroblast cell
growth, morphology, migration and ciliogenesis. Sci Rep.
5:165062015. View Article : Google Scholar : PubMed/NCBI
|
|
9
|
Lonergan KM, Chari R, Deleeuw RJ, Shadeo
A, Chi B, Tsao MS, Jones S, Marra M, Ling V, Ng R, et al:
Identification of novel lung genes in bronchial epithelium by
serial analysis of gene expression. Am J Respir Cell Mol Biol.
35:651–661. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
10
|
Steinbach D, Schramm A, Eggert A, Onda M,
Dawczynski K, Rump A, Pastan I, Wittig S, Pfaffendorf N, Voigt A,
et al: Identification of a set of seven genes for the monitoring of
minimal residual disease in pediatric acute myeloid leukemia. Clin
Cancer Res. 12:2434–2441. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
11
|
Zhang R, Zhu H, Yuan Y, Wang Y and Tian Z:
SPAG6 promotes cell proliferation and inhibits apoptosis through
the PTEN/PI3K/AKT pathway in Burkitt lymphoma. Oncol Rep.
44:2021–2030. 2020.PubMed/NCBI
|
|
12
|
Jiang M, Chen Y, Deng L, Luo X, Wang L and
Liu L: Upregulation of SPAG6 in myelodysplastic syndrome: Knockdown
inhibits cell proliferation via AKT/FOXO signaling pathway. DNA
Cell Biol. 38:476–484. 2019. View Article : Google Scholar : PubMed/NCBI
|
|
13
|
Ding L, Luo J, Zhang JP, Wang J, Li ZQ,
Huang J, Chai L, Mu J, Zhao B, Zhong YR, et al: Aberrant expression
of SPAG6 may affect the disease phenotype and serve as a tumor
biomarker in BCR/ABL1-negative myeloproliferative neoplasms. Oncol
Lett. 23:102022. View Article : Google Scholar
|
|
14
|
Zheng DF, Wang Q, Wang JP, Bao ZQ, Wu SW,
Ma L, Chai DM, Wang ZP and Tao YS: The emerging role of
sperm-associated antigen 6 gene in the microtubule function of
cells and cancer. Mol Ther Oncolytics. 15:101–107. 2019. View Article : Google Scholar : PubMed/NCBI
|
|
15
|
Zhang Z, Sapiro R, Kapfhamer D, Bucan M,
Bray J, Chennathukuzhi V, McNamara P, Curtis A, Zhang M,
Blanchette-Mackie EJ and Strauss JF III: A sperm-associated WD
repeat protein orthologous to Chlamydomonas PF20 associates with
Spag6, the mammalian orthologue of Chlamydomonas PF16. Mol Cell
Biol. 22:7993–8004. 2002. View Article : Google Scholar : PubMed/NCBI
|
|
16
|
Sapiro R, Tarantino LM, Velazquez F,
Kiriakidou M, Hecht NB, Bucan M and Strauss JF III: Sperm antigen 6
is the murine homologue of the Chlamydomonas reinhardtii central
apparatus protein encoded by the PF16 locus. Biol Reprod.
62:511–518. 2000. View Article : Google Scholar : PubMed/NCBI
|
|
17
|
Sapiro R, Kostetskii I, Olds-Clarke P,
Gerton GL, Radice GL and Strauss JF III: Male infertility, impaired
sperm motility, and hydrocephalus in mice deficient in
sperm-associated antigen 6. Mol Cell Biol. 22:6298–6305. 2002.
View Article : Google Scholar : PubMed/NCBI
|
|
18
|
Smith EF and Lefebvre PA: PF16 encodes a
protein with armadillo repeats and localizes to a single
microtubule of the central apparatus in Chlamydomonas flagella. J
Cell Biol. 132:359–370. 1996. View Article : Google Scholar : PubMed/NCBI
|
|
19
|
Meng X, Sun X, Liu Z and He Y: A novel era
of cancer/testis antigen in cancer immunotherapy. Int
Immunopharmacol. 98:1078892021. View Article : Google Scholar : PubMed/NCBI
|
|
20
|
Yang P, Meng M and Zhou Q: Oncogenic
cancer/testis antigens are a hallmarker of cancer and a sensible
target for cancer immunotherapy. Biochim Biophys Acta Rev Cancer.
1876:1885582021. View Article : Google Scholar : PubMed/NCBI
|
|
21
|
Wu Q, Liu J, Fang A, Li R, Bai Y,
Kriegstein AR and Wang X: The dynamics of neuronal migration. Adv
Exp Med Biol. 800:25–36. 2014. View Article : Google Scholar
|
|
22
|
Yan R, Hu X, Zhang Q, Song L, Zhang M,
Zhang Y and Zhao S: Spag6 negatively regulates neuronal migration
during mouse brain development. J Mol Neurosci. 57:463–469. 2015.
View Article : Google Scholar : PubMed/NCBI
|
|
23
|
Bogoyevitch MA, Yeap YY, Qu Z, Ngoei KR,
Yip YY, Zhao TT, Heng JI and Ng DC: WD40-repeat protein 62 is a
JNK-phosphorylated spindle pole protein required for spindle
maintenance and timely mitotic progression. J Cell Sci.
125:5096–5109. 2012.PubMed/NCBI
|
|
24
|
Li X, Zhang D, Xu L, Liu W, Zhang N,
Strauss JF III, Zhang Z and Wang H: Sperm-associated antigen 6
(Spag6) mutation leads to vestibular dysfunction in mice. J
Pharmacol Sci. 147:325–330. 2021. View Article : Google Scholar : PubMed/NCBI
|
|
25
|
Cooley LF, El Shikh ME, Li W, Keim RC,
Zhang Z, Strauss JF, Zhang Z and Conrad DH: Impaired immunological
synapse in sperm associated antigen 6 (SPAG6) deficient mice. Sci
Rep. 6:258402016. View Article : Google Scholar : PubMed/NCBI
|
|
26
|
de la Roche M, Ritter AT, Angus KL,
Dinsmore C, Earnshaw CH, Reiter JF and Griffiths GM: Hedgehog
signaling controls T cell killing at the immunological synapse.
Science. 342:1247–1250. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
27
|
Ralston KS, Lerner AG, Diener DR and Hill
KL: Flagellar motility contributes to cytokinesis in Trypanosoma
brucei and is modulated by an evolutionarily conserved dynein
regulatory system. Eukaryot Cell. 5:696–711. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
28
|
Branche C, Kohl L, Toutirais G, Buisson J,
Cosson J and Bastin P: Conserved and specific functions of axoneme
components in trypanosome motility. J Cell Sci. 119:3443–3455.
2006. View Article : Google Scholar : PubMed/NCBI
|
|
29
|
Straschil U, Talman AM, Ferguson DJP,
Bunting KA, Xu Z, Bailes E, Sinden RE, Holder AA, Smith EF, Coates
JC and Tewari R: The Armadillo repeat protein PF16 is essential for
flagellar structure and function in Plasmodium male gametes. PLoS
One. 5:e129012010. View Article : Google Scholar : PubMed/NCBI
|
|
30
|
Hu M, Ayub Q, Guerra-Assunção JA, Long Q,
Ning Z, Huang N, Romero IG, Mamanova L, Akan P, Liu X, et al:
Exploration of signals of positive selection derived from
genotype-based human genome scans using re-sequencing data. Hum
Genet. 131:665–674. 2012. View Article : Google Scholar :
|
|
31
|
Doxsey S: Re-evaluating centrosome
function. Nat Rev Mol Cell Biol. 2:688–698. 2001. View Article : Google Scholar : PubMed/NCBI
|
|
32
|
Vladar EK, Bayly RD, Sangoram AM, Scott MP
and Axelrod JD: Microtubules enable the planar cell polarity of
airway cilia. Curr Biol. 22:2203–2212. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
33
|
Majithia A, Fong J, Hariri M and Harcourt
J: Hearing outcomes in children with primary ciliary dyskinesia-a
longitudinal study. Int J Pediatr Otorhinolaryngol. 69:1061–1064.
2005. View Article : Google Scholar : PubMed/NCBI
|
|
34
|
Leigh MW, Pittman JE, Carson JL, Ferkol
TW, Dell SD, Davis SD, Knowles MR and Zariwala MA: Clinical and
genetic aspects of primary ciliary dyskinesia/Kartagener syndrome.
Genet Med. 11:473–487. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
35
|
Li H, Lv J, Zhou Q, Jin L, Kang Z and
Huang Y: Establishment of sperm associated antigen 6 gene knockout
mouse model and its mechanism of deafness. Saudi J Biol Sci.
27:1289–1295. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
36
|
Li X, Xu L, Li J, Li B, Bai X, Strauss JF
III, Zhang Z and Wang H: Otitis media in sperm-associated antigen 6
(Spag6)-deficient mice. PLoS One. 9:e1128792014. View Article : Google Scholar : PubMed/NCBI
|
|
37
|
Li X, Zhang D, Xu L, Han Y, Liu W, Li W,
Fan Z, Costanzo RM, Strauss JF III, Zhang Z and Wang H: Planar cell
polarity defects and hearing loss in sperm-associated antigen 6
(Spag6)-deficient mice. Am J Physiol Cell Physiol. 320:C132–C141.
2021.
|
|
38
|
Vallee RB and Tsai JW: The cellular roles
of the lissencephaly gene LIS1, and what they tell us about brain
development. Genes Dev. 20:1384–1393. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
39
|
Wang J, Li X, Zhang Z, Wang H and Li J:
Expression of prestin in OHCs is reduced in Spag6 gene knockout
mice. Neurosci Lett. 592:42–47. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
40
|
Farkas LM and Huttner WB: The cell biology
of neural stem and progenitor cells and its significance for their
proliferation versus differentiation during mammalian brain
development. Curr Opin Cell Biol. 20:707–715. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
41
|
Florio M and Huttner WB: Neural
progenitors, neurogenesis and the evolution of the neocortex.
Development. 141:2182–2194. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
42
|
Gilmore EC and Walsh CA: Genetic causes of
microcephaly and lessons for neuronal development. Wiley
Interdiscip Rev Dev Biol. 2:461–478. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
43
|
Guerrini R, Dobyns WB and Barkovich AJ:
Abnormal development of the human cerebral cortex: Genetics,
functional consequences and treatment options. Trends Neurosci.
31:154–162. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
44
|
Martin CA, Ahmad I, Klingseisen A, Hussain
MS, Bicknell LS, Leitch A, Nürnberg G, Toliat MR, Murray JE, Hunt
D, et al: Mutations in PLK4, encoding a master regulator of
centriole biogenesis, cause microcephaly, growth failure and
retinopathy. Nat Genet. 46:1283–1292. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
45
|
Hamada T, Teraoka M, Imaki J, Ui-Tei K,
Ladher RK and Asahara T: Gene expression of Spag6 in chick central
nervous system. Anat Histol Embryol. 39:227–232. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
46
|
Zhang Z, Tang W, Zhou R, Shen X, Wei Z,
Patel AM, Povlishock JT, Bennett J and Strauss JF III: Accelerated
mortality from hydrocephalus and pneumonia in mice with a combined
deficiency of SPAG6 and SPAG16L reveals a functional
interrelationship between the two central apparatus proteins. Cell
Motil Cytoskeleton. 64:360–376. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
47
|
Chen JF, Zhang Y, Wilde J, Hansen KC, Lai
F and Niswander L: Microcephaly disease gene Wdr62 regulates
mitotic progression of embryonic neural stem cells and brain size.
Nat Commun. 5:38852014. View Article : Google Scholar : PubMed/NCBI
|
|
48
|
Moon HM, Youn YH, Pemble H, Yingling J,
Wittmann T and Wynshaw-Boris A: LIS1 controls mitosis and mitotic
spindle organization via the LIS1-NDEL1-dynein complex. Hum Mol
Genet. 23:449–466. 2014. View Article : Google Scholar
|
|
49
|
Hu X, Yan R, Cheng X, Song L, Zhang W, Li
K and Zhao S: The function of sperm-associated antigen 6 in
neuronal proliferation and differentiation. J Mol Histol.
47:531–540. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
50
|
Fang WQ, Chen WW, Fu AKY and Ip NY: Axin
directs the amplification and differentiation of intermediate
progenitors in the developing cerebral cortex. Neuron. 79:665–679.
2013. View Article : Google Scholar : PubMed/NCBI
|
|
51
|
Mitchell B, Stubbs JL, Huisman F, Taborek
P, Yu C and Kintner C: The PCP pathway instructs the planar
orientation of ciliated cells in the Xenopus larval skin. Curr
Biol. 19:924–929. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
52
|
Fulda S and Debatin KM: Extrinsic versus
intrinsic apoptosis pathways in anticancer chemotherapy. Oncogene.
25:4798–4811. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
53
|
Shen Y, Chow J, Wang Z and Fan G: Abnormal
CpG island methylation occurs during in vitro differentiation of
human embryonic stem cells. Hum Mol Genet. 15:2623–3635. 2006.
View Article : Google Scholar : PubMed/NCBI
|
|
54
|
Janke C and Bulinski JC:
Post-translational regulation of the microtubule cytoskeleton:
Mechanisms and functions. Nat Rev Mol Cell Biol. 12:773–786. 2011.
View Article : Google Scholar : PubMed/NCBI
|
|
55
|
Vaughan EE, Geiger RC, Miller AM,
Loh-Marley PL, Suzuki T, Miyata N and Dean DA: Microtubule
acetylation through HDAC6 inhibition results in increased
transfection efficiency. Mol Ther. 16:1841–1847. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
56
|
Bullinger L, Döhner K and Döhner H:
Genomics of acute myeloid leukemia diagnosis and pathways. J Clin
Oncol. 35:934–946. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
57
|
Kim Y, Yeon M and Jeoung D: DDX53
regulates cancer stem cell-like properties by binding to SOX-2. Mol
Cells. 40:322–330. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
58
|
Li Y, Li J, Wang Y, Zhang Y, Chu J, Sun C,
Fu Z, Huang Y, Zhang H, Yuan H and Yin Y: Roles of cancer/testis
antigens CTAs) in breast cancer. Cancer Lett. 399:64–73. 2017.
View Article : Google Scholar : PubMed/NCBI
|
|
59
|
van Duin M, Broyl A, de Knegt Y,
Goldschmidt H, Richardson PG, Hop WC, van der Holt B,
Joseph-Pietras D, Mulligan G, Neuwirth R, et al: Cancer testis
antigens in newly diagnosed and relapse multiple myeloma:
Prognostic markers and potential targets for immunotherapy.
Haematologica. 96:1662–1669. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
60
|
Gera K, Chauhan A, Castillo P, Rahman M,
Mathavan A, Mathavan A, Oganda-Rivas E, Elliott L, Wingard JR and
Sayour EJ: Vaccines: A promising therapy for myelodysplastic
syndrome. J Hematol Oncol. 17:42024. View Article : Google Scholar : PubMed/NCBI
|
|
61
|
Lee P, Yim R, Yung Y, Chu HT, Yip PK and
Gill H: Molecular targeted therapy and immunotherapy for
myelodysplastic syndrome. Int J Mol Sci. 22:102322021. View Article : Google Scholar : PubMed/NCBI
|
|
62
|
Li X, Yang B, Wang L, Chen L, Luo X and
Liu L: SPAG6 regulates cell apoptosis through the TRAIL signal
pathway in myelodysplastic syndromes. Oncol Rep. 37:2839–2846.
2017. View Article : Google Scholar : PubMed/NCBI
|
|
63
|
Yin J, Li X, Zhang Z, Luo X, Wang L and
Liu L: SPAG6 silencing induces apoptosis in the myelodysplastic
syndrome cell line SKM-1 via the PTEN/PI3K/AKT signaling pathway in
vitro and in vivo. Int J Oncol. 53:297–306. 2018.PubMed/NCBI
|
|
64
|
Zhang M, Luo J, Luo X and Liu L: SPAG6
silencing induces autophagic cell death in SKM-1 cells via the
AMPK/mTOR/ULK1 signaling pathway. Oncol Lett. 20:551–560. 2020.
View Article : Google Scholar : PubMed/NCBI
|
|
65
|
Luo J, Mu J, Zhang M, Zhao B and Liu L:
SPAG6-silencing enhances decitabine-induced apoptosis and
demethylation of PTEN in SKM-1 cells and in a xenograft mouse
model. Leuk Lymphoma. 62:2242–2252. 2021. View Article : Google Scholar : PubMed/NCBI
|
|
66
|
Luo J, Mu J and Liu L: Effects of SPAG6
silencing and decitabine treatment on apoptosis and phosphatase and
tensin homolog methylation in SKM-1 cells. Zhonghua Xue Ye Xue Za
Zhi. 42:1005–1010. 2021.In Chinese.
|
|
67
|
Papaemmanuil E, Gerstung M, Bullinger L,
Gaidzik VI, Paschka P, Roberts ND, Potter NE, Heuser M, Thol F,
Bolli N, et al: Genomic classification and prognosis in acute
myeloid leukemia. N Engl J Med. 374:2209–2221. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
68
|
Patel JP, Gönen M, Figueroa ME, Fernandez
H, Sun Z, Racevskis J, Van Vlierberghe P, Dolgalev I, Thomas S,
Aminova O, et al: Prognostic relevance of integrated genetic
profiling in acute myeloid leukemia. N Engl J Med. 366:1079–1089.
2012. View Article : Google Scholar : PubMed/NCBI
|
|
69
|
Stubbins RJ, Francis A, Kuchenbauer F and
Sanford D: Management of acute myeloid leukemia: A review for
general practitioners in oncology. Curr Oncol. 29:6245–6259. 2022.
View Article : Google Scholar : PubMed/NCBI
|
|
70
|
Luo J, Zhao H, Zang X and Liu L: High
expression of SPAG6 acts as a pro-tumor factor and associated with
poor prognosis in acute myeloid leukemia. Int J Lab Hematol.
47:680–689. 2025. View Article : Google Scholar : PubMed/NCBI
|
|
71
|
Steinbach D, Bader P, Willasch A,
Bartholomae S, Debatin KM, Zimmermann M, Creutzig U, Reinhardt D
and Gruhn B: Prospective validation of a new method of monitoring
minimal residual disease in childhood acute myelogenous leukemia.
Clin Cancer Res. 21:1353–1359. 2015. View Article : Google Scholar
|
|
72
|
Skou AS, Juul-Dam KL, Hansen M, Lausen B,
Stratmann S, Holmfeldt L, Aggerholm A, Nyvold CG, Ommen HB and
Hasle H: Measurable residual disease monitoring of SPAG6, ST18,
PRAME, and XAGE1A expression in peripheral blood may detect
imminent relapse in childhood acute myeloid leukemia. J Mol Diagn.
23:1787–1799. 2021. View Article : Google Scholar : PubMed/NCBI
|
|
73
|
Mu J, Yuan P, Luo J, Chen Y, Tian Y, Ding
L, Zhao B, Wang X, Wang B and Liu L: Upregulated SPAG6 promotes
acute myeloid leukemia progression through MYO1D that regulates the
EGFR family expression. Blood Adv. 6:5379–5394. 2022. View Article : Google Scholar : PubMed/NCBI
|
|
74
|
Passet M, Kim R and Clappier E: Genetic
subtypes of B-cell acute lymphoblastic leukemia in adults. Blood.
145:1451–1463. 2025. View Article : Google Scholar : PubMed/NCBI
|
|
75
|
Yasuda T, Sanada M, Tsuzuki S and Hayakawa
F: Oncogenic lesions and molecular subtypes in adults with B-cell
acute lymphoblastic leukemia. Cancer Sci. 114:8–15. 2023.
View Article : Google Scholar :
|
|
76
|
Zhao B, Yin J, Ding L, Luo J, Luo J, Mu J,
Pan S, Du J, Zhong Y, Zhang L and Liu L: SPAG6 regulates cell
proliferation and apoptosis via TGF-β/Smad signal pathway in adult
B-cell acute lymphoblastic leukemia. Int J Hematol. 119:119–129.
2024. View Article : Google Scholar
|
|
77
|
Cowan AJ, Green DJ, Kwok M, Lee S, Coffey
DG, Holmberg LA, Tuazon S, Gopal AK and Libby EN: Diagnosis and
management of multiple myeloma: A review. JAMA. 327:464–477. 2022.
View Article : Google Scholar : PubMed/NCBI
|
|
78
|
Kyle RA and Rajkumar SV: Multiple myeloma.
Blood. 111:2962–2972. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
79
|
Li J, Yan X, Ding L, Yin J, Li P and Liu
L: SPAG6 promotes multiple myeloma through activation of the
MAPK/ERK signaling pathway. Front Pharmacol. 16:15726212025.
View Article : Google Scholar : PubMed/NCBI
|
|
80
|
Luque Paz D, Kralovics R and Skoda RC:
Genetic basis and molecular profiling in myeloproliferative
neoplasms. Blood. 141:1909–1921. 2023. View Article : Google Scholar
|
|
81
|
Morishita S and Komatsu N: Diagnosis- and
prognosis-related gene alterations in BCR::ABL1-negative
myeloproliferative neoplasms. Int J Mol Sci. 24:130082023.
View Article : Google Scholar : PubMed/NCBI
|
|
82
|
Xia Y, Li X, Tian X and Zhao Q:
Identification of a five-gene signature derived from MYCN
amplification and establishment of a nomogram for predicting the
prognosis of neuroblastoma. Front Mol Biosci. 8:7696612021.
View Article : Google Scholar : PubMed/NCBI
|
|
83
|
Ding L, Luo J, Du J, Zhao B, Luo J, Pan S,
Zhang L, Yan X, Li J and Liu L: Upregulated SPAG6 correlates with
increased STAT1 and is associated with reduced sensitivity of
interferon-α response in BCR::ABL1 negative myeloproliferative
neoplasms. Cancer Sci. 114:4445–4458. 2023. View Article : Google Scholar : PubMed/NCBI
|
|
84
|
López C, Burkhardt B, Chan JKC, Leoncini
L, Mbulaiteye SM, Ogwang MD, Orem J, Rochford R, Roschewski M and
Siebert R: Burkitt lymphoma. Nat Rev Dis Primers. 8:782022.
View Article : Google Scholar : PubMed/NCBI
|
|
85
|
Fang H, Wang W and Medeiros LJ: Burkitt
lymphoma. Hum Pathol. 156:1057032025. View Article : Google Scholar
|
|
86
|
Li X, Wang Y, Li X, Kong L, Díez JJ, Wang
H and Zhang D: A comprehensive pan-cancer analysis revealing SPAG6
as a novel diagnostic, prognostic and immunological biomarker in
tumor. Gland Surg. 13:999–1015. 2024. View Article : Google Scholar : PubMed/NCBI
|
|
87
|
Hutchinson L: Breast cancer: Challenges,
controversies, breakthroughs. Nat Rev Clin Oncol. 7:669–670. 2010.
View Article : Google Scholar : PubMed/NCBI
|
|
88
|
Xiong X, Zheng LW, Ding Y, Chen YF, Cai
YW, Wang LP, Huang L, Liu CC, Shao ZM and Yu KD: Breast cancer:
Pathogenesis and treatments. Signal Transduct Target Ther.
10:492025. View Article : Google Scholar : PubMed/NCBI
|
|
89
|
Conn VM, Chinnaiyan AM and Conn SJ:
Circular RNA in cancer. Nat Rev Cancer. 24:597–613. 2024.
View Article : Google Scholar : PubMed/NCBI
|
|
90
|
Fan S, Cui Y, Liu Y, Li Y, Huang H and Hu
Z: CircMYH9 promotes the mRNA stability of SPAG6 by recruiting
EIF4A3 to facilitate the progression of breast cancer. Epigenetics.
20:24823822025. View Article : Google Scholar : PubMed/NCBI
|
|
91
|
Mijnes J, Tiedemann J, Eschenbruch J,
Gasthaus J, Bringezu S, Bauerschlag D, Maass N, Arnold N, Weimer J,
Anzeneder T, et al: SNiPER: A novel hypermethylation biomarker
panel for liquid biopsy based early breast cancer detection.
Oncotarget. 10:6494–6508. 2019. View Article : Google Scholar : PubMed/NCBI
|
|
92
|
Manoochehri M, Borhani N, Gerhäuser C,
Assenov Y, Schönung M, Hielscher T, Christensen BC, Lee MK, Gröne
HJ, Lipka DB, et al: DNA methylation biomarkers for noninvasive
detection of triple-negative breast cancer using liquid biopsy. Int
J Cancer. 152:1025–1035. 2023. View Article : Google Scholar
|
|
93
|
Tang LL, Chen YP, Chen CB, Chen MY, Chen
NY, Chen XZ, Du XJ, Fang WF, Feng M, Gao J, et al: The Chinese
society of clinical oncology CSCO) clinical guidelines for the
diagnosis and treatment of nasopharyngeal carcinoma. Cancer Commun
(Lond). 41:1195–1227. 2021. View Article : Google Scholar : PubMed/NCBI
|
|
94
|
Chen YP, Chan ATC, Le QT, Blanchard P, Sun
Y and Ma J: Nasopharyngeal carcinoma. Lancet. 394:64–80. 2019.
View Article : Google Scholar : PubMed/NCBI
|
|
95
|
Zhang H, Ma J, An S, Xu L, Lu J and Jiang
C: Screen of key characteristic genes of nasopharyngeal carcinoma
(NPC) base on machine learning and analysis of their correlation
with immune cells. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 39:988–995.
2023.In Chinese. PubMed/NCBI
|
|
96
|
Cabanillas ME, McFadden DG and Durante C:
Thyroid cancer. Lancet. 388:2783–2795. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
97
|
Pacifico F and Leonardi A: Role of
NF-kappaB in thyroid cancer. Mol Cell Endocrinol. 321:29–35. 2010.
View Article : Google Scholar
|
|
98
|
Abaandou L, Ghosh R and Klubo-Gwiezdzinska
J: The role of the hypothalamic-pituitary-thyroid axis in thyroid
cancer. Lancet Diabetes Endocrinol. 13:333–346. 2025. View Article : Google Scholar : PubMed/NCBI
|
|
99
|
Wang H: LINC00092 enhances LPP expression
to repress thyroid cancer development via sponging miR-542-3p. Horm
Metab Res. 56:150–158. 2024. View Article : Google Scholar
|
|
100
|
Waldman A and Schmults C: Cutaneous
squamous cell carcinoma. Hematol Oncol Clin North Am. 33:1–12.
2019. View Article : Google Scholar
|
|
101
|
Burton KA, Ashack KA and Khachemoune A:
Cutaneous squamous cell carcinoma: A review of high-risk and
metastatic disease. Am J Clin Dermatol. 17:491–508. 2016.
View Article : Google Scholar : PubMed/NCBI
|
|
102
|
Gim JA, Kim C, Oh HJ, Kim KE, Jeon J, Kim
A and Baek YS: Spatial transcriptomics shows a distinctive tumour
microenvironment in the invasive versus premalignant portion of
early cutaneous squamous cell carcinoma. Exp Dermatol.
34:e701252025. View Article : Google Scholar : PubMed/NCBI
|
|
103
|
Kansara M, Teng MW, Smyth MJ and Thomas
DM: Translational biology of osteosarcoma. Nat Rev Cancer.
14:722–735. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
104
|
Chen C, Xie L, Ren T, Huang Y, Xu J and
Guo W: Immunotherapy for osteosarcoma: Fundamental mechanism,
rationale, and recent breakthroughs. Cancer Lett. 500:1–10. 2021.
View Article : Google Scholar
|
|
105
|
Bao Z, Zhu R, Fan H, Ye Y, Li T and Chai
D: Aberrant expression of SPAG6 and NM23 predicts poor prognosis of
human osteosarcoma. Front Genet. 13:10125482022. View Article : Google Scholar : PubMed/NCBI
|
|
106
|
Coscio AM and Garst J: Lung cancer in
women. Curr Oncol Rep. 8:248–251. 2006. View Article : Google Scholar
|
|
107
|
Thai AA, Solomon BJ, Sequist LV, Gainor JF
and Heist RS: Lung cancer. Lancet. 398:535–554. 2021. View Article : Google Scholar : PubMed/NCBI
|
|
108
|
Zheng Y, Sadée C, Ozawa M, Howitt BE and
Gevaert O: Single-cell multimodal analysis reveals tumor
microenvironment predictive of treatment response in non-small cell
lung cancer. Sci Adv. 11:eadu21512025. View Article : Google Scholar : PubMed/NCBI
|
|
109
|
Kontic M and Markovic F: Use of DNA
methylation patterns for early detection and management of lung
cancer: Are we there yet? Oncol Res. 33:781–793. 2025. View Article : Google Scholar : PubMed/NCBI
|
|
110
|
Bonanno L, Favaretto A, Rugge M, Taron M
and Rosell R: Role of genotyping in non-small cell lung cancer
treatment: Current status. Drugs. 71:2231–2246. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
111
|
Rigas JR and Kelly K: Current treatment
paradigms for locally advanced non-small cell lung cancer. J Thorac
Oncol. 2(Suppl 2): S77–S85. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
112
|
Altenberger C, Heller G, Ziegler B,
Tomasich E, Marhold M, Topakian T, Müllauer L, Heffeter P, Lang G,
End-Pfützenreuter A, et al: SPAG6 and L1TD1 are transcriptionally
regulated by DNA methylation in non-small cell lung cancers. Mol
Cancer. 16:12017. View Article : Google Scholar : PubMed/NCBI
|
|
113
|
Wang Y, Liu Y, Wang R, Cao F, Guan Y, Chen
Y, An B, Qin S and Yao S: Establishment of a prognostic model
toward lung squamous cell carcinoma based on m7G-related
genes in the cancer genome atlas. Physiol Genomics. 55:427–439.
2023. View Article : Google Scholar : PubMed/NCBI
|
|
114
|
Wu Q, Yan Y, Shi S, Qi Q and Han J:
DNMT3b-mediated SPAG6 promoter hypermethylation affects lung
squamous cell carcinoma development through the JAK/STAT pathway.
Am J Transl Res. 14:6964–6977. 2022.PubMed/NCBI
|
|
115
|
Hao Q, Li J, Zhang Q, Xu F, Xie B, Lu H,
Wu X and Zhou X: Single-cell transcriptomes reveal heterogeneity of
high-grade serous ovarian carcinoma. Clin Transl Med. 11:e5002021.
View Article : Google Scholar : PubMed/NCBI
|
|
116
|
Wang Y, Xie H, Chang X, Hu W, Li M, Li Y,
Liu H, Cheng H, Wang S, Zhou L, et al: Single-cell dissection of
the multiomic landscape of high-grade serous ovarian cancer. Cancer
Res. 82:3903–3916. 2022. View Article : Google Scholar : PubMed/NCBI
|
|
117
|
Coan M, Rampioni Vinciguerra GL, Cesaratto
L, Gardenal E, Bianchet R, Dassi E, Vecchione A, Baldassarre G,
Spizzo R and Nicoloso MS: Exploring the role of fallopian ciliated
cells in the pathogenesis of high-grade serous ovarian cancer. Int
J Mol Sci. 19:25122018. View Article : Google Scholar : PubMed/NCBI
|
|
118
|
Berdik C: Unlocking bladder cancer.
Nature. 551:S34–S35. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
119
|
Grayson M: Bladder cancer. Nature.
551:S332017. View Article : Google Scholar : PubMed/NCBI
|
|
120
|
Kitchen MO, Bryan RT, Haworth KE, Emes RD,
Luscombe C, Gommersall L, Cheng KK, Zeegers MP, James ND, Devall
AJ, et al: Methylation of HOXA9 and ISL1 predicts patient outcome
in high-grade non-invasive bladder cancer. PLoS One.
10:e01370032015. View Article : Google Scholar : PubMed/NCBI
|
|
121
|
Huo FY, Li YS, Yang XY, Wang QX, Liu JJ,
Wang LK, Su YH and Sun L: Expressions of SLC22A14 and SPAG6
proteins in the ejaculated sperm of idiopathic asthenozoospermia
patients. Zhonghua Nan Ke Xue. 23:703–707. 2017.In Chinese.
|
|
122
|
Yu H, Shi X, Shao Z, Geng H, Guo S, Li K,
Gu M, Xu C, Gao Y, Tan Q, et al: Novel HYDIN variants associated
with male infertility in two Chinese families. Front Endocrinol
(Lausanne). 14:11188412023. View Article : Google Scholar : PubMed/NCBI
|
|
123
|
Xu C, Tang D, Shao Z, Geng H, Gao Y, Li K,
Tan Q, Wang G, Wang C, Wu H, et al: Homozygous SPAG6 variants can
induce nonsyndromic asthenoteratozoospermia with severe MMAF.
Reprod Biol Endocrinol. 20:412022. View Article : Google Scholar : PubMed/NCBI
|
|
124
|
Li DY, Yang XX, Tu CF, Wang WL, Meng LL,
Lu GX, Tan YQ, Zhang QJ and Du J: Sperm flagellar 2 (SPEF2) is
essential for sperm flagellar assembly in humans. Asian J Androl.
24:359–366. 2022. View Article : Google Scholar :
|
|
125
|
Wu H, Wang J, Cheng H, Gao Y, Liu W, Zhang
Z, Jiang H, Li W, Zhu F, Lv M, et al: Patients with severe
asthenoteratospermia carrying SPAG6 or RSPH3 mutations have a
positive pregnancy outcome following intracytoplasmic sperm
injection. J Assist Reprod Genet. 37:829–840. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
126
|
Tan C, Meng L, Lv M, He X, Sha Y, Tang D,
Tan Y, Hu T, He W, Tu C, et al: Bi-allelic variants in DNHD1 cause
flagellar axoneme defects and asthenoteratozoospermia in humans and
mice. Am J Hum Genet. 109:157–171. 2022. View Article : Google Scholar :
|
|
127
|
Jiang T, Wang Y, Wu W, Yang Q, Wu S, Zhang
X and Xu W: Distinct germ-line genetic mutation patterns correlate
with reproductive outcomes in ICSI patients: A pilot study. Front
Genet. 16:16109432025. View Article : Google Scholar : PubMed/NCBI
|
|
128
|
Ren H, Zhang Y, Bi Y, Wang H, Fang G and
Zhao P: Target silencing of porcine SPAG6 and PPP1CC by shRNA
attenuated sperm motility. Theriogenology. 219:138–146. 2024.
View Article : Google Scholar : PubMed/NCBI
|
|
129
|
Ye JW, Abbas T, Zhou JT, Chen J, Yang ML,
Huang XH, Zhang H, Ma H, Ma A, Xu B, et al: Homozygous CCDC146
mutation causes oligoasthenoteratozoospermia in humans and mice.
Zool Res. 45:1073–1087. 2024. View Article : Google Scholar : PubMed/NCBI
|
|
130
|
He X, Liu C, Yang X, Lv M, Ni X, Li Q,
Cheng H, Liu W, Tian S, Wu H, et al: Bi-allelic loss-of-function
variants in CFAP58 cause flagellar axoneme and mitochondrial sheath
defects and asthenoteratozoospermia in humans and mice. Am J Hum
Genet. 107:514–526. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
131
|
Sun W, Zhang X, Wang L, Ren G, Piao S,
Yang C and Liu Z: RNA sequencing profiles reveals progressively
reduced spermatogenesis with progression in adult cryptorchidism.
Front Endocrinol (Lausanne). 14:12717242023. View Article : Google Scholar : PubMed/NCBI
|
