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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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April-2026 Volume 68 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Review

Mechanisms of chemoresistance in diffuse large B‑cell lymphoma and novel therapeutic strategies (Review)

  • Authors:
    • Mengdi Wan
    • Xi Wang
    • Bin Luo
    • Huangming Hong
    • Yizhun Zhu
    • Tongyu Lin
  • View Affiliations / Copyright

    Affiliations: School of Pharmacy, Faculty of Medicine, Macau University of Science and Technology, Macau SAR 999078, P.R. China, Department of Emergency Medicine, Chengdu Second People's Hospital, Chengdu, Sichuan 610017, P.R. China, Department of Medical Oncology, Sichuan Cancer Hospital and Institute, Sichuan Cancer Center, University of Electronic Science and Technology of China, Chengdu, Sichuan, 610054, P.R. China
  • Article Number: 46
    |
    Published online on: February 20, 2026
       https://doi.org/10.3892/ijo.2026.5859
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Abstract

Diffuse large B‑cell lymphoma (DLBCL), the most prevalent subtype of lymphoma, is characterized by rapid growth and a poor prognosis, with the R‑CHOP regimen (rituximab, cyclophosphamide, doxorubicin, vincristine and prednisone) being the standard first‑line therapy. However, 30‑40% of patients experience early relapse or refractoriness to treatment, highlighting the need to understand the mechanisms of chemoresistance. The present review synthesizes the current knowledge on the molecular mechanisms underlying chemoresistance in DLBCL, including genetic mutations, epigenetic modifications, aberrant activation of signaling pathways, alterations in drug metabolism and efflux, and upregulation of anti‑apoptotic proteins. In addition, the role of the tumor microenvironment in mediating therapeutic resistance is discussed and biomarkers associated with chemoresistance are explored. Furthermore, novel therapeutic strategies targeting chemoresistance, such as immunotherapy, metabolic modulators and epigenetic therapies, are examined. Understanding these mechanisms is crucial for developing effective treatment strategies to overcome resistance and improve patient outcomes in DLBCL.

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Copy and paste a formatted citation
Spandidos Publications style
Wan M, Wang X, Luo B, Hong H, Zhu Y and Lin T: Mechanisms of chemoresistance in diffuse large B‑cell lymphoma and novel therapeutic strategies (Review). Int J Oncol 68: 46, 2026.
APA
Wan, M., Wang, X., Luo, B., Hong, H., Zhu, Y., & Lin, T. (2026). Mechanisms of chemoresistance in diffuse large B‑cell lymphoma and novel therapeutic strategies (Review). International Journal of Oncology, 68, 46. https://doi.org/10.3892/ijo.2026.5859
MLA
Wan, M., Wang, X., Luo, B., Hong, H., Zhu, Y., Lin, T."Mechanisms of chemoresistance in diffuse large B‑cell lymphoma and novel therapeutic strategies (Review)". International Journal of Oncology 68.4 (2026): 46.
Chicago
Wan, M., Wang, X., Luo, B., Hong, H., Zhu, Y., Lin, T."Mechanisms of chemoresistance in diffuse large B‑cell lymphoma and novel therapeutic strategies (Review)". International Journal of Oncology 68, no. 4 (2026): 46. https://doi.org/10.3892/ijo.2026.5859
Copy and paste a formatted citation
x
Spandidos Publications style
Wan M, Wang X, Luo B, Hong H, Zhu Y and Lin T: Mechanisms of chemoresistance in diffuse large B‑cell lymphoma and novel therapeutic strategies (Review). Int J Oncol 68: 46, 2026.
APA
Wan, M., Wang, X., Luo, B., Hong, H., Zhu, Y., & Lin, T. (2026). Mechanisms of chemoresistance in diffuse large B‑cell lymphoma and novel therapeutic strategies (Review). International Journal of Oncology, 68, 46. https://doi.org/10.3892/ijo.2026.5859
MLA
Wan, M., Wang, X., Luo, B., Hong, H., Zhu, Y., Lin, T."Mechanisms of chemoresistance in diffuse large B‑cell lymphoma and novel therapeutic strategies (Review)". International Journal of Oncology 68.4 (2026): 46.
Chicago
Wan, M., Wang, X., Luo, B., Hong, H., Zhu, Y., Lin, T."Mechanisms of chemoresistance in diffuse large B‑cell lymphoma and novel therapeutic strategies (Review)". International Journal of Oncology 68, no. 4 (2026): 46. https://doi.org/10.3892/ijo.2026.5859
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