|
1
|
Bray F, Laversanne M, Sung H, Ferlay J,
Siegel RL, Soerjomataram I and Jemal A: Global cancer statistics
2022: GLOBOCAN estimates of incidence and mortality worldwide for
36 cancers in 185 countries. CA Cancer J Clin. 74:229–263.
2024.PubMed/NCBI
|
|
2
|
Mirhadi S, Tam S, Li Q, Moghal N, Pham NA,
Tong J, Golbourn BJ, Krieger JR, Taylor P, Li M, et al: Integrative
analysis of non-small cell lung cancer patient-derived xenografts
identifies distinct proteotypes associated with patient outcomes.
Nat Commun. 13:18112022. View Article : Google Scholar : PubMed/NCBI
|
|
3
|
Ye Q, Zhou L, Jin P, Li L, Zheng S, Huang
Z, Liu J, Qin S, Liu H, Zou B and Xie K: Guaiazulene triggers
ROS-induced apoptosis and protective autophagy in non-small cell
lung cancer. Front Pharmacol. 12:6211812021. View Article : Google Scholar : PubMed/NCBI
|
|
4
|
Yang J, He X, Lv Q, Jing J and Shi H:
Management of adverse events in cancer patients treated with
PD-1/PD-L1 blockade: Focus on Asian populations. Front Pharmacol.
10:7262019. View Article : Google Scholar : PubMed/NCBI
|
|
5
|
Hu T, Gong H, Xu J, Huang Y, Wu F and He
Z: Nanomedicines for overcoming cancer drug resistance.
Pharmaceutics. 14:16062022. View Article : Google Scholar : PubMed/NCBI
|
|
6
|
Yu L, Lai Q, Gou L, Feng J and Yang J:
Opportunities and obstacles of targeted therapy and immunotherapy
in small cell lung cancer. J Drug Target. 29:1–11. 2021. View Article : Google Scholar
|
|
7
|
Luan Y, Xian D, Zhao C, Qing X, He H,
Zheng K, Song W, Jiang T, Wang W and Duan C: Therapeutic targets
for lung cancer: Genome-wide Mendelian randomization and
colocalization analyses. Front Pharmacol. 15:14412332024.
View Article : Google Scholar : PubMed/NCBI
|
|
8
|
Zhang C, Shao J, Tang X, Wu J, Li P, Li W
and Wang C: The real-world treatment characteristic and efficacy of
immune checkpoint inhibitors in non-small cell lung cancer: Data
from a retrospective cohort study. Int Immunopharmacol.
134:1121522024. View Article : Google Scholar : PubMed/NCBI
|
|
9
|
Dong J, Li B, Lin D, Zhou Q and Huang D:
Advances in targeted therapy and immunotherapy for non-small cell
lung cancer based on accurate molecular typing. Front Pharmacol.
10:2302019. View Article : Google Scholar : PubMed/NCBI
|
|
10
|
Hiltbrunner S, Cords L, Kasser S,
Freiberger SN, Kreutzer S, Toussaint NC, Grob L, Opitz I, Messerli
M, Zoche M, et al: Acquired resistance to anti-PD1 therapy in
patients with NSCLC associates with immunosuppressive T cell
phenotype. Nat Commun. 14:51542023. View Article : Google Scholar : PubMed/NCBI
|
|
11
|
Liang H, Xu Y, Zhao J, Chen M and Wang M:
Hippo pathway in non-small cell lung cancer: Mechanisms, potential
targets, and biomarkers. Cancer Gene Ther. 31:652–666. 2024.
View Article : Google Scholar : PubMed/NCBI
|
|
12
|
Wang Y, Zhou Y, Zhou K, Li J and Che G:
Prognostic value of pre-treatment red blood cell distribution width
in lung cancer: A meta-analysis. Biomarkers. 25:241–247. 2020.
View Article : Google Scholar : PubMed/NCBI
|
|
13
|
Zhang J, Ren Z, Hu Y, Shang S, Wang R, Ma
J, Zhang Z, Wu M, Wang F, Yu J and Chen D: High
HPK1+PD-1+TIM-3+CD8+ T
cells infiltration predicts poor prognosis to immunotherapy in
NSCLC patients. Int Immunopharmacol. 127:1113632024. View Article : Google Scholar
|
|
14
|
Yuan M, Huang LL, Chen JH, Wu J and Xu Q:
The emerging treatment landscape of targeted therapy in
non-small-cell lung cancer. Signal Transduct Target Ther. 4:612019.
View Article : Google Scholar : PubMed/NCBI
|
|
15
|
Lin Q, Qu M, Patra HK, He S, Wang L, Hu X,
Xiao L, Fu Y, Gong T, He Q, et al: Mechanistic and therapeutic
study of novel anti-tumor function of natural compound imperialine
for treating non-small cell lung cancer. J Ethnopharmacol.
247:1122832020. View Article : Google Scholar
|
|
16
|
Lan T, He S, Luo X, Pi Z, Lai W, Jiang C,
Gan J, Wei S, Wu Z, Yun C, et al: Disruption of NADPH homeostasis
by total flavonoids from Adinandra nitida Merr. Ex Li leaves
triggers ROS-dependent p53 activation leading to apoptosis in
non-small cell lung cancer cells. J Ethnopharmacol. 332:1183402024.
View Article : Google Scholar : PubMed/NCBI
|
|
17
|
Liu Y, Luo X, Liu J, Ma Y, Tan J, Wang W,
Hu J, Fu X, Xu L, Yu F, et al: Shenlingcao oral liquid for patients
with non-small cell lung cancer receiving adjuvant chemotherapy
after radical resection: A multicenter randomized controlled trial.
Phytomedicine. 113:1547232023. View Article : Google Scholar : PubMed/NCBI
|
|
18
|
Ni Y, Liu J, Zeng L, Yang Y, Liu L, Yao M,
Chai L, Zhang L, Li Y, Zhang L and Li W: Natural product manoalide
promotes EGFR-TKI sensitivity of lung cancer cells by KRAS-ERK
pathway and mitochondrial Ca2+ overload-induced
ferroptosis. Front Pharmacol. 13:11098222023. View Article : Google Scholar
|
|
19
|
Yang S, Zhang Y, Luo Y, Xu B, Yao Y, Deng
Y, Yang F, Ye T, Wang G, Cheng Z, et al: Hinokiflavone induces
apoptosis in melanoma cells through the ROS-mitochondrial apoptotic
pathway and impairs cell migration and invasion. Biomed
Pharmacother. 103:101–110. 2018. View Article : Google Scholar : PubMed/NCBI
|
|
20
|
Zheng Y, Wang PP, Fu Y, Chen YY and Ding
ZY: Zoledronic acid enhances the efficacy of immunotherapy in
non-small cell lung cancer. Int Immunopharmacol. 110:1090302022.
View Article : Google Scholar : PubMed/NCBI
|
|
21
|
Atanasov AG, Zotchev SB, Dirsch VM, Orhan
IE, Banach M, Rollinger JM, Barreca D, Weckwerth W, Bauer R, Bayer
EA, et al: Natural products in drug discovery: Advances and
opportunities. Nat Rev Drug Discov. 20:200–216. 2021. View Article : Google Scholar : PubMed/NCBI
|
|
22
|
Li Z, Zhao H, Ouyang H, Wang Q, Chen J,
Feng Y and Yang S: New compounds with anti-inflammatory potential
from Disporum cantoniense. Phytochem Lett. 22:92–94. 2017.
View Article : Google Scholar
|
|
23
|
Chen L, Su YF, Yin ZY, Luo XH, Wu ZH, Gao
XM and Zhang BL: Flavonoids from Disporum cantoniense (Liliaceae).
Biochem Syst Ecol. 37:609–612. 2009. View Article : Google Scholar
|
|
24
|
Panche AN, Diwan AD and Chandra SR:
Flavonoids: An overview. J Nutr Sci. 5:e472016. View Article : Google Scholar
|
|
25
|
Yan W, Yang J, Tang H, Xue L, Chen K, Wang
L, Zhao M, Tang M, Peng A, Long C, et al: Flavonoids from the stems
of Millettia pachyloba Drake mediate cytotoxic activity through
apoptosis and autophagy in cancer cells. J Adv Res. 20:117–127.
2019. View Article : Google Scholar : PubMed/NCBI
|
|
26
|
Lipinski CA: Lead- and drug-like
compounds: The rule-of-five revolution. Drug Discov Today Technol.
1:337–341. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
27
|
Pan Y, Wei J, Qin D, Zhou X, Gao F, Yu L,
Feng C, Mi J, Wu J, Law BYK, et al: Prosapogenin CP4 exacerbates
mitophagy to induce apoptosis via AMPK-mTOR and PINK1/Parkin
pathways in A549 cells. Phytomedicine. 148:1573332025. View Article : Google Scholar : PubMed/NCBI
|
|
28
|
Yong YY, Yan L, Wang BD, Fan DS, Guo MS,
Yu L, Wu JM, Qin DL, Law BYK, Wong VKW, et al: Penthorum chinense
Pursh inhibits ferroptosis in cellular and Caenorhabditis elegans
models of Alzheimer's disease. Phytomedicine. 127:1554632024.
View Article : Google Scholar : PubMed/NCBI
|
|
29
|
Qiu WQ, Ai W, Zhu FD, Zhang Y, Guo MS, Law
BYK, Wu JM, Wong VKW, Tang Y, Yu L, et al: Polygala saponins
inhibit NLRP3 inflammasome-mediated neuroinflammation via
SHP-2-mediated mitophagy. Free Radic Biol Med. 179:76–94. 2022.
View Article : Google Scholar
|
|
30
|
Qiu WQ, Yu L, He CL, Wu JM, Law BYK, Yu
CL, Qin DL, Zhou XG and Wu AG: Two 18-norspirostane steroidal
saponins as novel mitophagy enhancers improve Alzheimer's disease.
Clin Transl Med. 13:e13902023. View Article : Google Scholar : PubMed/NCBI
|
|
31
|
Chen X, Zhou XY, Lan C, Fu HJ, Li ZC, Chen
MY, Wen YP, Yu L, Qin DL, Wu AG, et al: Araloside A induces
Raf/MEK/ERK-dependent autophagy to mitigate Alzheimer's and
Parkinson's pathology in cellular and C. elegans models. Mol
Neurobiol. 62:16061–16080. 2025. View Article : Google Scholar : PubMed/NCBI
|
|
32
|
Stefanowicz Hajduk J and Ochocka JR:
Real-time cell analysis system in cytotoxicity applications:
Usefulness and comparison with tetrazolium salt assays. Toxicol
Rep. 7:335–344. 2020. View Article : Google Scholar : PubMed/NCBI
|
|
33
|
Justus CR, Marie MA, Sanderlin EJ and Yang
LV: Transwell in vitro cell migration and invasion assays. Methods
Mol Biol. 2644:349–359. 2023. View Article : Google Scholar : PubMed/NCBI
|
|
34
|
Teng JF, Mei QB, Zhou XG, Tang Y, Xiong R,
Qiu WQ, Pan R, Law BYK, Wong VKW, Yu CL, et al: Polyphyllin VI
induces caspase-1-mediated pyroptosis via the induction of
ROS/NF-κB/NLRP3/GSDMD signal axis in non-small cell lung cancer.
Cancers (Basel). 12:1932020. View Article : Google Scholar
|
|
35
|
Yan H, Wang S, Hu Y, Jing R, Liu L, Liu P,
Yin H and Mu L: AG8 induces apoptosis and ferroptosis through
regulating caspase 3 and SLC7A11/GPX4 signaling pathway in
triple-negative breast cancer. Clin Tradit Med Pharmacol.
6:2002222025. View Article : Google Scholar
|
|
36
|
Chen X, Xie Q, Cheng X, Diao X, Cheng Y,
Liu J, Xie W, Chen Z and Zhu B: Role of interleukin-17 in
lymphangiogenesis in non-small-cell lung cancer: Enhanced
production of vascular endothelial growth factor C in
non-small-cell lung carcinoma cells. Cancer Sci. 101:2384–2390.
2010. View Article : Google Scholar : PubMed/NCBI
|
|
37
|
Balikci Cicek I and Kucukakcali Z:
Transcriptomic profiling of gastric cancer reveals key biomarkers
and pathways via bioinformatic analysis. Genes (Basel). 16:8292025.
View Article : Google Scholar : PubMed/NCBI
|
|
38
|
Luo W, Deng J, He J, Yin L, You R, Zhang
L, Shen J, Han Z, Xie F, He J and Guan Y: Integration of molecular
docking, molecular dynamics and network pharmacology to explore the
multi-target pharmacology of fenugreek against diabetes. J Cell Mol
Med. 27:1959–1974. 2023. View Article : Google Scholar : PubMed/NCBI
|
|
39
|
Guo M, Wang Z, Zhou X, Yu C, Wu J, Yu L,
Mi J, Ren F, Law BYK, Pan H, et al: Ciliatoside A attenuates
neuroinflammation in Alzheimer's disease by activating mitophagy
and inhibiting NLRP3 inflammasome activation. Phytomedicine.
145:1569282025. View Article : Google Scholar : PubMed/NCBI
|
|
40
|
Chang TM, Chi MC, Chiang YC, Lin CM, Fang
ML, Lee CW, Liu JF and Kou YR: Promotion of ROS-mediated apoptosis,
G2/M arrest, and autophagy by naringenin in non-small cell lung
cancer. Int J Biol Sci. 20:1093–1109. 2024. View Article : Google Scholar : PubMed/NCBI
|
|
41
|
Chen C, Ou W, Yang C, Liu H, Yang T, Mo H,
Lu W, Yan J and Chen A: Queen bee acid pretreatment attenuates
myocardial ischemia/reperfusion injury by enhancing autophagic
flux. Heliyon. 10:e333712024. View Article : Google Scholar : PubMed/NCBI
|
|
42
|
Gong Y, Luo S, Fan P, Zhu H, Li Y and
Huang W: Growth hormone activates PI3K/Akt signaling and inhibits
ROS accumulation and apoptosis in granulosa cells of patients with
polycystic ovary syndrome. Reprod Biol Endocrinol. 18:1212020.
View Article : Google Scholar : PubMed/NCBI
|
|
43
|
Dai S, Wei J, Zhang H, Luo P, Yang Y,
Jiang X, Fei Z, Liang W, Jiang J and Li X: Intermittent fasting
reduces neuroinflammation in intracerebral hemorrhage through the
Sirt3/Nrf2/HO-1 pathway. J Neuroinflammation. 19:1222022.
View Article : Google Scholar : PubMed/NCBI
|
|
44
|
Yong Y, Yan L, Wei J, Feng C, Yu L, Wu J,
Guo M, Fan D, Yu C, Qin D, et al: A novel ferroptosis inhibitor,
Thonningianin A, improves Alzheimer's disease by activating GPX4.
Theranostics. 14:6161–6184. 2024. View Article : Google Scholar : PubMed/NCBI
|
|
45
|
Vijaya Kumar A, Donate C, Imhof BA and
Matthes T: Tumor engraftment in a xenograft mouse model of human
mantle cell lymphoma. J Vis Exp. 56023:2018.
|
|
46
|
Tang X, Ding H, Liang M, Chen X, Yan Y,
Wan N, Chen Q, Zhang J and Cao J: Curcumin induces ferroptosis in
non-small-cell lung cancer via activating autophagy. Thorac Cancer.
12:1219–1230. 2021. View Article : Google Scholar : PubMed/NCBI
|
|
47
|
Xie C, Zhou X, Liang C, Li X, Ge M, Chen
Y, Yin J, Zhu J and Zhong C: Apatinib triggers autophagic and
apoptotic cell death via VEGFR2/STAT3/PD-L1 and ROS/Nrf2/p62
signaling in lung cancer. J Exp Clin Cancer Res. 40:2662021.
View Article : Google Scholar : PubMed/NCBI
|
|
48
|
Zhang X, Zheng X, Ying X, Xie W, Yin Y and
Wang X: CEBPG suppresses ferroptosis through transcriptional
control of SLC7A11 in ovarian cancer. J Transl Med. 21:3342023.
View Article : Google Scholar : PubMed/NCBI
|
|
49
|
Meyer ML, Fitzgerald BG, Paz Ares L,
Cappuzzo F, Jänne PA, Peters S and Hirsch FR: New promises and
challenges in the treatment of advanced non-small-cell lung cancer.
Lancet. 404:803–822. 2024. View Article : Google Scholar : PubMed/NCBI
|
|
50
|
Yang Y, Wang H, Xue Q, Peng W and Zhou Q:
New advances of natural products in non-small cell lung cancer:
From mechanisms to therapies. J Ethnopharmacol. 346:1196362025.
View Article : Google Scholar : PubMed/NCBI
|
|
51
|
Liu G, Pei F, Yang F, Li L, Amin AD, Liu
S, Buchan JR and Cho WC: Role of autophagy and apoptosis in
non-small-cell lung cancer. Int J Mol Sci. 18:3672017. View Article : Google Scholar : PubMed/NCBI
|
|
52
|
Liu H, Yao Q, Wang X, Xie H, Yang C, Gao H
and Xie C: The research progress of crosstalk mechanism of
autophagy and apoptosis in diabetic vascular endothelial injury.
Biomed Pharmacother. 170:1160722024. View Article : Google Scholar
|
|
53
|
Lyu L, Hu Y, Yin S, Wang L, Ye F, Wang M,
Zhou Y, Ma W, Chen C, Jiang Y, et al: Autophagy inhibition enhances
anti-pituitary adenoma effect of tetrandrine. Phytother Res.
35:4007–4021. 2021. View Article : Google Scholar : PubMed/NCBI
|
|
54
|
Tang F, Zhang JN, Zhao XL, Xu LY, Ao H and
Peng C: Unlocking the dual role of autophagy: A new strategy for
treating lung cancer. J Pharm Anal. 15:1010982025. View Article : Google Scholar : PubMed/NCBI
|
|
55
|
Qin P, Li Q, Zu Q, Dong R and Qi Y:
Natural products targeting autophagy and apoptosis in NSCLC: A
novel therapeutic strategy. Front Oncol. 14:13796982024. View Article : Google Scholar : PubMed/NCBI
|
|
56
|
Jain V, Singh MP and Amaravadi RK: Recent
advances in targeting autophagy in cancer. Trends Pharmacol Sci.
44:290–302. 2023. View Article : Google Scholar : PubMed/NCBI
|
|
57
|
Denton D and Kumar S: Autophagy-dependent
cell death. Cell Death Differ. 26:605–616. 2019. View Article : Google Scholar
|
|
58
|
Galluzzi L, Vitale I, Aaronson SA, Abrams
JM, Adam D, Agostinis P, Alnemri ES, Altucci L, Amelio I, Andrews
DW, et al: Molecular mechanisms of cell death: Recommendations of
the nomenclature committee on cell death 2018. Cell Death Differ.
25:486–541. 2018. View Article : Google Scholar : PubMed/NCBI
|
|
59
|
Kim J, Kundu M, Viollet B and Guan KL:
AMPK and mTOR regulate autophagy through direct phosphorylation of
Ulk1. Nat Cell Biol. 13:132–141. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
60
|
Wang W, Jiang J, Huang Y, Peng F, Hu T, Wu
J, Pan X and Rao C: Aconitine induces autophagy via activating
oxidative DNA damage-mediated AMPK/ULK1 signaling pathway in H9c2
cells. J Ethnopharmacol. 282:1146312022. View Article : Google Scholar
|
|
61
|
Liu X, Wu J, Wang N, Xia L, Fan S, Lu Y,
Chen X, Shang S, Yang Y, Huang Q, et al: Artesunate reverses LPS
tolerance by promoting ULK1-mediated autophagy through interference
with the CaMKII-IP3R-CaMKKβ pathway. Int Immunopharmacol.
87:1068632020. View Article : Google Scholar
|
|
62
|
Cagnol S and Chambard JC: ERK and cell
death: Mechanisms of ERK-induced cell death-apoptosis, autophagy
and senescence. FEBS J. 277:2–21. 2010. View Article : Google Scholar
|
|
63
|
Huang Y, Zhen Y, Chen Y, Sui S and Zhang
L: Unraveling the interplay between RAS/RAF/MEK/ERK signaling
pathway and autophagy in cancer: From molecular mechanisms to
targeted therapy. Biochem Pharmacol. 217:1158422023. View Article : Google Scholar : PubMed/NCBI
|
|
64
|
Timofeev O, Giron P, Lawo S, Pichler M and
Noeparast M: ERK pathway agonism for cancer therapy: Evidence,
insights, and a target discovery framework. NPJ Precis Oncol.
8:702024. View Article : Google Scholar : PubMed/NCBI
|
|
65
|
Vogler M, Braun Y, Smith VM, Westhoff MA,
Pereira RS, Pieper NM, Anders M, Callens M, Vervliet T, Abbas M, et
al: The BCL2 family: From apoptosis mechanisms to new advances in
targeted therapy. Signal Transduct Target Ther. 10:912025.
View Article : Google Scholar : PubMed/NCBI
|
|
66
|
Fares J, Fares MY, Khachfe HH, Salhab HA
and Fares Y: Molecular principles of metastasis: A hallmark of
cancer revisited. Signal Transduct Target Ther. 5:282020.
View Article : Google Scholar : PubMed/NCBI
|