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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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July 2002 Volume 21 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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July 2002 Volume 21 Issue 1

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Article

Human cytomegalovirus in neoplastic cells of Epstein-Barr virus negative Hodgkin's disease

  • Authors:
    • Gaosheng Huang
    • Qingguo Yan
    • Zhe Wang
    • Xiequn Chen
    • Xiaohui Zhang
    • Ying Guo
    • Jian Jian Li

  • View Affiliations / Copyright

    Affiliations: Department of Pathology, XiJin Hospital, The Fourth Military Medical University, Xi'an 710032, PR China. huanggs@fmmu.edu.cn
  • Pages: 31-36
    |
    Published online on: July 1, 2002
       https://doi.org/10.3892/ijo.21.1.31
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Abstract

Although Epstein-Barr virus (EBV) infection has been implicated in the development of a subset of Hodgkin's disease, the etiology of EBV-negative Hodgkin's disease remains to be determined. We investigated the status of human cytomegalovirus (hCMV) infection in 42 cases of Hodgkin's disease in a Chinese population. Using a nested polymerase chain reaction assay, nine of the 42 cases (21.4%) were found to contain EBV DNA. While only one of the nine EBV-positive cases demonstrated amplifiable hCMV DNA, approximately 33.3% of the EBV-negative cases (11/33) showed molecular evidence of hCMV infection (8 mixed cellularity; 2 nodular sclerosis; and 1 lymphocyte depletion). All 17 lymph nodes with non-specific reactive changes were negative for hCMV DNA. The presence of hCMV in Reed-Sternberg cells and their variants was further confirmed by single-cell polymerase chain reaction, in situ hybridization and immunohistochemical analysis, which demonstrated ~50% amplified hCMV DNA. These results suggest for the first time that hCMV infection plays a potential role in signaling the cell transformation and pathogenesis of Hodgkin's disease, particularly in EBV-negative cases.

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Copy and paste a formatted citation
Spandidos Publications style
Huang G, Yan Q, Wang Z, Chen X, Zhang X, Guo Y and Li JJ: Human cytomegalovirus in neoplastic cells of Epstein-Barr virus negative Hodgkin's disease. Int J Oncol 21: 31-36, 2002.
APA
Huang, G., Yan, Q., Wang, Z., Chen, X., Zhang, X., Guo, Y., & Li, J.J. (2002). Human cytomegalovirus in neoplastic cells of Epstein-Barr virus negative Hodgkin's disease. International Journal of Oncology, 21, 31-36. https://doi.org/10.3892/ijo.21.1.31
MLA
Huang, G., Yan, Q., Wang, Z., Chen, X., Zhang, X., Guo, Y., Li, J. J."Human cytomegalovirus in neoplastic cells of Epstein-Barr virus negative Hodgkin's disease". International Journal of Oncology 21.1 (2002): 31-36.
Chicago
Huang, G., Yan, Q., Wang, Z., Chen, X., Zhang, X., Guo, Y., Li, J. J."Human cytomegalovirus in neoplastic cells of Epstein-Barr virus negative Hodgkin's disease". International Journal of Oncology 21, no. 1 (2002): 31-36. https://doi.org/10.3892/ijo.21.1.31
Copy and paste a formatted citation
x
Spandidos Publications style
Huang G, Yan Q, Wang Z, Chen X, Zhang X, Guo Y and Li JJ: Human cytomegalovirus in neoplastic cells of Epstein-Barr virus negative Hodgkin's disease. Int J Oncol 21: 31-36, 2002.
APA
Huang, G., Yan, Q., Wang, Z., Chen, X., Zhang, X., Guo, Y., & Li, J.J. (2002). Human cytomegalovirus in neoplastic cells of Epstein-Barr virus negative Hodgkin's disease. International Journal of Oncology, 21, 31-36. https://doi.org/10.3892/ijo.21.1.31
MLA
Huang, G., Yan, Q., Wang, Z., Chen, X., Zhang, X., Guo, Y., Li, J. J."Human cytomegalovirus in neoplastic cells of Epstein-Barr virus negative Hodgkin's disease". International Journal of Oncology 21.1 (2002): 31-36.
Chicago
Huang, G., Yan, Q., Wang, Z., Chen, X., Zhang, X., Guo, Y., Li, J. J."Human cytomegalovirus in neoplastic cells of Epstein-Barr virus negative Hodgkin's disease". International Journal of Oncology 21, no. 1 (2002): 31-36. https://doi.org/10.3892/ijo.21.1.31
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