Survivin expression and its correlation with cell proliferation and prognosis in epithelial ovarian tumors

  • Authors:
    • Li Sui
    • Youyi Dong
    • Masayuki Ohno
    • Yasuo Watanabe
    • Katsuyoshi Sugimoto
    • Masaaki Tokuda
  • View Affiliations

  • Published online on: August 1, 2002     https://doi.org/10.3892/ijo.21.2.315
  • Pages: 315-320
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Abstract

Survivin is a new member of the inhibitors of apoptosis proteins (IAP) family, selectively overexpressed in common human cancers but not in normal adult tissues, and associated with aggressiveness of the disease and unfavorable outcomes. Recent study also found that survivin expression is associated with cell proliferation. In order to gain insight into the role of survivin in ovarian tumors, we investigated the expression of survivin in a group of epithelial ovarian tumors, and examined the relationship of its expression with cell proliferation and clinical outcome. Immunohistochemical analysis was performed in 103 cases of epithelial ovarian tumors. Twenty-six of the 103 cases were evaluated by Western blot analysis. The results showed that survivin overexpression was detected in 21.2% (7 of 33) of benign tumors, 47.8% (11 of 23) of borderline tumors, and 51.1% (24 of 47) of ovarian carcinomas. The positive ratio was significantly higher in malignant or borderline tumors than in benign tumors, and the overexpression of survivin was significantly correlated with the size of residual disease. A positive correlation between survivin expression and proliferative activity of tumor cell measured by PCNA index was found. Kaplan-Meier analysis demonstrated that the patients with survivin overexpression have a short overall survival. These findings suggest that survivin overexpression may play a pivotal role in the progression of ovarian tumors and may provide an important prognostic implication for epithelial ovarian carcinomas.

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August 2002
Volume 21 Issue 2

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Sui L, Dong Y, Ohno M, Watanabe Y, Sugimoto K and Tokuda M: Survivin expression and its correlation with cell proliferation and prognosis in epithelial ovarian tumors. Int J Oncol 21: 315-320, 2002.
APA
Sui, L., Dong, Y., Ohno, M., Watanabe, Y., Sugimoto, K., & Tokuda, M. (2002). Survivin expression and its correlation with cell proliferation and prognosis in epithelial ovarian tumors. International Journal of Oncology, 21, 315-320. https://doi.org/10.3892/ijo.21.2.315
MLA
Sui, L., Dong, Y., Ohno, M., Watanabe, Y., Sugimoto, K., Tokuda, M."Survivin expression and its correlation with cell proliferation and prognosis in epithelial ovarian tumors". International Journal of Oncology 21.2 (2002): 315-320.
Chicago
Sui, L., Dong, Y., Ohno, M., Watanabe, Y., Sugimoto, K., Tokuda, M."Survivin expression and its correlation with cell proliferation and prognosis in epithelial ovarian tumors". International Journal of Oncology 21, no. 2 (2002): 315-320. https://doi.org/10.3892/ijo.21.2.315