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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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October 2002 Volume 21 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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October 2002 Volume 21 Issue 4

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Article

Maturational sequence of neuroblastoma revealed by molecular analysis on cDNA microarrays

  • Authors:
    • Yasunari Yamanaka
    • Yutaka Hamazaki
    • Yoko Sato
    • Kiminari Ito
    • Ken-Ichiro Watanabe
    • Toshio Heike
    • Tatsutoshi Nakahata
    • Yusuke Nakamura
  • View Affiliations / Copyright

    Affiliations: Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo 108-8639, Japan
  • Pages: 803-807
    |
    Published online on: October 1, 2002
       https://doi.org/10.3892/ijo.21.4.803
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Abstract

Neuroblastoma (NB), one of the most common solid tumors among children, is histologically classified by the degree of maturation. To elucidate the mechanisms underlying its maturational sequence, we analyzed gene-expression profiles of 14 NB tumors on cDNA microarrays consisting of 23,040 genes. Computational analysis identified 78 genes whose expression levels were significantly different between differentiating NB tumors and poorly differentiated NB tumors. This group included genes associated with cell maturation and apoptosis. Among them we identified 15 that were up-regulated in Stage IV NB tumors; these included genes encoding cell adhesion molecules and cytoskeleton proteins. The set of genes we report here should contribute to a better understanding of NB tumor maturation and could lead to development of new therapeutic strategies.

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Copy and paste a formatted citation
Spandidos Publications style
Yamanaka Y, Hamazaki Y, Sato Y, Ito K, Watanabe K, Heike T, Nakahata T and Nakamura Y: Maturational sequence of neuroblastoma revealed by molecular analysis on cDNA microarrays. Int J Oncol 21: 803-807, 2002.
APA
Yamanaka, Y., Hamazaki, Y., Sato, Y., Ito, K., Watanabe, K., Heike, T. ... Nakamura, Y. (2002). Maturational sequence of neuroblastoma revealed by molecular analysis on cDNA microarrays. International Journal of Oncology, 21, 803-807. https://doi.org/10.3892/ijo.21.4.803
MLA
Yamanaka, Y., Hamazaki, Y., Sato, Y., Ito, K., Watanabe, K., Heike, T., Nakahata, T., Nakamura, Y."Maturational sequence of neuroblastoma revealed by molecular analysis on cDNA microarrays". International Journal of Oncology 21.4 (2002): 803-807.
Chicago
Yamanaka, Y., Hamazaki, Y., Sato, Y., Ito, K., Watanabe, K., Heike, T., Nakahata, T., Nakamura, Y."Maturational sequence of neuroblastoma revealed by molecular analysis on cDNA microarrays". International Journal of Oncology 21, no. 4 (2002): 803-807. https://doi.org/10.3892/ijo.21.4.803
Copy and paste a formatted citation
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Spandidos Publications style
Yamanaka Y, Hamazaki Y, Sato Y, Ito K, Watanabe K, Heike T, Nakahata T and Nakamura Y: Maturational sequence of neuroblastoma revealed by molecular analysis on cDNA microarrays. Int J Oncol 21: 803-807, 2002.
APA
Yamanaka, Y., Hamazaki, Y., Sato, Y., Ito, K., Watanabe, K., Heike, T. ... Nakamura, Y. (2002). Maturational sequence of neuroblastoma revealed by molecular analysis on cDNA microarrays. International Journal of Oncology, 21, 803-807. https://doi.org/10.3892/ijo.21.4.803
MLA
Yamanaka, Y., Hamazaki, Y., Sato, Y., Ito, K., Watanabe, K., Heike, T., Nakahata, T., Nakamura, Y."Maturational sequence of neuroblastoma revealed by molecular analysis on cDNA microarrays". International Journal of Oncology 21.4 (2002): 803-807.
Chicago
Yamanaka, Y., Hamazaki, Y., Sato, Y., Ito, K., Watanabe, K., Heike, T., Nakahata, T., Nakamura, Y."Maturational sequence of neuroblastoma revealed by molecular analysis on cDNA microarrays". International Journal of Oncology 21, no. 4 (2002): 803-807. https://doi.org/10.3892/ijo.21.4.803
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