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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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November 2002 Volume 21 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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November 2002 Volume 21 Issue 5

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Article

Macro-microscopic fluorescence imaging of human NPC xenografts in a murine model using topical vs intravenous administration of 5-aminolevulinic acid

  • Authors:
    • Vanaja Manivasager
    • Paul Wan Sia Heng
    • Jinsong Hao
    • Wei Zheng
    • Khee Chee Soo
    • Malini Olivo

  • View Affiliations / Copyright

    Affiliations: Division of Medical Sciences, National Cancer Centre, Singapore 169610
  • Pages: 1003-1007
    |
    Published online on: November 1, 2002
       https://doi.org/10.3892/ijo.21.5.1003
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Abstract

The use of 5-aminolevulinic acid to induce endogenous porphyrins for the purpose of detection of epithelial cancers is being studied extensively in many centres around the world. The challenge is to prepare an efficacious formulation of 5-ALA for the purpose of cancer detection. In this study, we compared two formulations of topical 5-ALA applications with intravenous administration in NPC/CNE-2 xenografts on balb/c nude mice. One of the formulations was a gantrez muco-adhesive patch and the other was a polyvinyl-pyrolidone muco-adhesive patch. The Karl Storz fluorescence endoscopy system was used to obtain macroscopic fluorescence images. Microscopic fluorescence imaging was done by laser confocal microscopy. The macroscopic images were further analysed for fluorescence intensity distribution. It was found that between the two formulations of topical application of 5-ALA; there was very little difference in the fluorescence biodistribution. When the topical applications were compared with the intravenous administration, the tumour to normal differential in biodistribution was significantly higher with the topical application compared to the intravenous application.

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Copy and paste a formatted citation
Spandidos Publications style
Manivasager V, Heng PW, Hao J, Zheng W, Soo KC and Olivo M: Macro-microscopic fluorescence imaging of human NPC xenografts in a murine model using topical vs intravenous administration of 5-aminolevulinic acid. Int J Oncol 21: 1003-1007, 2002.
APA
Manivasager, V., Heng, P.W., Hao, J., Zheng, W., Soo, K.C., & Olivo, M. (2002). Macro-microscopic fluorescence imaging of human NPC xenografts in a murine model using topical vs intravenous administration of 5-aminolevulinic acid. International Journal of Oncology, 21, 1003-1007. https://doi.org/10.3892/ijo.21.5.1003
MLA
Manivasager, V., Heng, P. W., Hao, J., Zheng, W., Soo, K. C., Olivo, M."Macro-microscopic fluorescence imaging of human NPC xenografts in a murine model using topical vs intravenous administration of 5-aminolevulinic acid". International Journal of Oncology 21.5 (2002): 1003-1007.
Chicago
Manivasager, V., Heng, P. W., Hao, J., Zheng, W., Soo, K. C., Olivo, M."Macro-microscopic fluorescence imaging of human NPC xenografts in a murine model using topical vs intravenous administration of 5-aminolevulinic acid". International Journal of Oncology 21, no. 5 (2002): 1003-1007. https://doi.org/10.3892/ijo.21.5.1003
Copy and paste a formatted citation
x
Spandidos Publications style
Manivasager V, Heng PW, Hao J, Zheng W, Soo KC and Olivo M: Macro-microscopic fluorescence imaging of human NPC xenografts in a murine model using topical vs intravenous administration of 5-aminolevulinic acid. Int J Oncol 21: 1003-1007, 2002.
APA
Manivasager, V., Heng, P.W., Hao, J., Zheng, W., Soo, K.C., & Olivo, M. (2002). Macro-microscopic fluorescence imaging of human NPC xenografts in a murine model using topical vs intravenous administration of 5-aminolevulinic acid. International Journal of Oncology, 21, 1003-1007. https://doi.org/10.3892/ijo.21.5.1003
MLA
Manivasager, V., Heng, P. W., Hao, J., Zheng, W., Soo, K. C., Olivo, M."Macro-microscopic fluorescence imaging of human NPC xenografts in a murine model using topical vs intravenous administration of 5-aminolevulinic acid". International Journal of Oncology 21.5 (2002): 1003-1007.
Chicago
Manivasager, V., Heng, P. W., Hao, J., Zheng, W., Soo, K. C., Olivo, M."Macro-microscopic fluorescence imaging of human NPC xenografts in a murine model using topical vs intravenous administration of 5-aminolevulinic acid". International Journal of Oncology 21, no. 5 (2002): 1003-1007. https://doi.org/10.3892/ijo.21.5.1003
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