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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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November 2002 Volume 21 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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November 2002 Volume 21 Issue 5

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Article

Evaluation of NQO1 gene expression and variant allele in human NSCLC tumors and matched normal lung tissue

  • Authors:
    • Jill M. Kolesar
    • Stuart C. Pritchard
    • Keith M. Kerr
    • Kyungman Kim
    • Marianne C. Nicolson
    • Howard McLeod

  • View Affiliations / Copyright

    Affiliations: School of Pharmacy, University of Wisconsin-Madison, Madison, WI 53706-1515, USA. jmkolesar@pharmacy.wisc.edu
  • Pages: 1119-1124
    |
    Published online on: November 1, 2002
       https://doi.org/10.3892/ijo.21.5.1119
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Abstract

NQO1 gene expression was evaluated by RT-PCR and SNP status by RFLP in matched samples of lung tumors and adjacent normal tissue. NQO1 was found to be overexpressed in lung tumors when compared to matched normal lung tissue. The mean expression in normal lung tissue was 28.26x10-14 ng/μl ± 44.9 SD and 61.46x10-14 ng/μl ± 103.2 SD in lung tumors. NQO1 gene expression was higher in the tumor than in the matched normal lung tissue in 27/50 (59%) patients (p=0.014). In the normal samples, 25 (50%) were wild-type, 16 were heterozygotes (32%) and 8 had the SNP (16%). In the matched tumor samples 14 were wild-type (28%), 16 were heterozygous (32%) and 19 (38%) had the SNP (p=0.0043). The genomic NQO1 mutation was associated with survival in a pilot study of stage II/III NSCLC patients. Patients with a homozygous SNP genotype had a significantly shorter survival (median 12 months), than heterozygous or homozygous wild-type patients (median 41 months) (p=0.007), suggesting NQO1 may be important in chemosensitivity as well as the pathogenesis of lung cancer and NQO1 genotyping may be a useful component of pharmacogenetic strategies for the treatment of NSCLC.

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Copy and paste a formatted citation
Spandidos Publications style
Kolesar JM, Pritchard SC, Kerr KM, Kim K, Nicolson MC and McLeod H: Evaluation of NQO1 gene expression and variant allele in human NSCLC tumors and matched normal lung tissue. Int J Oncol 21: 1119-1124, 2002.
APA
Kolesar, J.M., Pritchard, S.C., Kerr, K.M., Kim, K., Nicolson, M.C., & McLeod, H. (2002). Evaluation of NQO1 gene expression and variant allele in human NSCLC tumors and matched normal lung tissue. International Journal of Oncology, 21, 1119-1124. https://doi.org/10.3892/ijo.21.5.1119
MLA
Kolesar, J. M., Pritchard, S. C., Kerr, K. M., Kim, K., Nicolson, M. C., McLeod, H."Evaluation of NQO1 gene expression and variant allele in human NSCLC tumors and matched normal lung tissue". International Journal of Oncology 21.5 (2002): 1119-1124.
Chicago
Kolesar, J. M., Pritchard, S. C., Kerr, K. M., Kim, K., Nicolson, M. C., McLeod, H."Evaluation of NQO1 gene expression and variant allele in human NSCLC tumors and matched normal lung tissue". International Journal of Oncology 21, no. 5 (2002): 1119-1124. https://doi.org/10.3892/ijo.21.5.1119
Copy and paste a formatted citation
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Spandidos Publications style
Kolesar JM, Pritchard SC, Kerr KM, Kim K, Nicolson MC and McLeod H: Evaluation of NQO1 gene expression and variant allele in human NSCLC tumors and matched normal lung tissue. Int J Oncol 21: 1119-1124, 2002.
APA
Kolesar, J.M., Pritchard, S.C., Kerr, K.M., Kim, K., Nicolson, M.C., & McLeod, H. (2002). Evaluation of NQO1 gene expression and variant allele in human NSCLC tumors and matched normal lung tissue. International Journal of Oncology, 21, 1119-1124. https://doi.org/10.3892/ijo.21.5.1119
MLA
Kolesar, J. M., Pritchard, S. C., Kerr, K. M., Kim, K., Nicolson, M. C., McLeod, H."Evaluation of NQO1 gene expression and variant allele in human NSCLC tumors and matched normal lung tissue". International Journal of Oncology 21.5 (2002): 1119-1124.
Chicago
Kolesar, J. M., Pritchard, S. C., Kerr, K. M., Kim, K., Nicolson, M. C., McLeod, H."Evaluation of NQO1 gene expression and variant allele in human NSCLC tumors and matched normal lung tissue". International Journal of Oncology 21, no. 5 (2002): 1119-1124. https://doi.org/10.3892/ijo.21.5.1119
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