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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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November 2002 Volume 21 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Medicine International

An International Open Access Journal Devoted to General Medicine.

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November 2002 Volume 21 Issue 5

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Article

Transforming growth factor α, amphiregulin and cripto-1 are frequently expressed in advanced human ovarian carcinomas

  • Authors:
    • Antonio D'Antonio
    • Simona Losito
    • Sandro Pignata
    • Michele Grassi
    • Francesco Perrone
    • Antonella De Luca
    • Rosa Tambaro
    • Caterina Bianco
    • William J. Gullick
    • Gibbes R. Johnson
    • Vincenzo R. Iaffaioli
    • David S. Salomon
    • Nicola Normanno

  • View Affiliations / Copyright

    Affiliations: Anatomia Patologica AORN Cardarelli, Naples, Italy
  • Pages: 941-948
    |
    Published online on: November 1, 2002
       https://doi.org/10.3892/ijo.21.5.941
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Abstract

The expression of transforming growth factor α (TGFα), amphiregulin (AR) and cripto-1 (CR-1) was assessed by immunohistochemistry in 83 specimens (59 primary ovarian tumors and 24 extra-ovarian carcinomas) that were obtained from 68 ovarian carcinoma patients. Within the 59 primary tumors, 54 (92%) expressed immunoreactive TGFα, 45 (76%) expressed AR, and 28 (47%) expressed CR-1. The expression of AR and CR-1 mRNAs in the ovarian carcinomas was also demonstrated by RT-PCR analysis. Seventeen extra-ovarian specimens (71%) were found to express CR-1, whereas AR and TGFα were expressed respectively in 21 (87%) and 22 (92%) extra-ovarian tissues. In 15 cases for whom both ovarian and extra-ovarian tissues were available, a statistically significant higher expression of CR-1 was found in extra-ovarian specimens. A statistically significant correlation was found between AR expression in the ovarian carcinomas and both low grade and low proliferative activity. Finally, expression of TGFα was predictive of longer progression-free survival. These data strongly suggest that the EGF-related peptides might be involved in the pathogenesis and outcome of human ovarian cancer.

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Copy and paste a formatted citation
Spandidos Publications style
D'Antonio A, Losito S, Pignata S, Grassi M, Perrone F, De Luca A, Tambaro R, Bianco C, Gullick WJ, Johnson GR, Johnson GR, et al: Transforming growth factor α, amphiregulin and cripto-1 are frequently expressed in advanced human ovarian carcinomas. Int J Oncol 21: 941-948, 2002.
APA
D'Antonio, A., Losito, S., Pignata, S., Grassi, M., Perrone, F., De Luca, A. ... Normanno, N. (2002). Transforming growth factor α, amphiregulin and cripto-1 are frequently expressed in advanced human ovarian carcinomas. International Journal of Oncology, 21, 941-948. https://doi.org/10.3892/ijo.21.5.941
MLA
D'Antonio, A., Losito, S., Pignata, S., Grassi, M., Perrone, F., De Luca, A., Tambaro, R., Bianco, C., Gullick, W. J., Johnson, G. R., Iaffaioli, V. R., Salomon, D. S., Normanno, N."Transforming growth factor α, amphiregulin and cripto-1 are frequently expressed in advanced human ovarian carcinomas". International Journal of Oncology 21.5 (2002): 941-948.
Chicago
D'Antonio, A., Losito, S., Pignata, S., Grassi, M., Perrone, F., De Luca, A., Tambaro, R., Bianco, C., Gullick, W. J., Johnson, G. R., Iaffaioli, V. R., Salomon, D. S., Normanno, N."Transforming growth factor α, amphiregulin and cripto-1 are frequently expressed in advanced human ovarian carcinomas". International Journal of Oncology 21, no. 5 (2002): 941-948. https://doi.org/10.3892/ijo.21.5.941
Copy and paste a formatted citation
x
Spandidos Publications style
D'Antonio A, Losito S, Pignata S, Grassi M, Perrone F, De Luca A, Tambaro R, Bianco C, Gullick WJ, Johnson GR, Johnson GR, et al: Transforming growth factor α, amphiregulin and cripto-1 are frequently expressed in advanced human ovarian carcinomas. Int J Oncol 21: 941-948, 2002.
APA
D'Antonio, A., Losito, S., Pignata, S., Grassi, M., Perrone, F., De Luca, A. ... Normanno, N. (2002). Transforming growth factor α, amphiregulin and cripto-1 are frequently expressed in advanced human ovarian carcinomas. International Journal of Oncology, 21, 941-948. https://doi.org/10.3892/ijo.21.5.941
MLA
D'Antonio, A., Losito, S., Pignata, S., Grassi, M., Perrone, F., De Luca, A., Tambaro, R., Bianco, C., Gullick, W. J., Johnson, G. R., Iaffaioli, V. R., Salomon, D. S., Normanno, N."Transforming growth factor α, amphiregulin and cripto-1 are frequently expressed in advanced human ovarian carcinomas". International Journal of Oncology 21.5 (2002): 941-948.
Chicago
D'Antonio, A., Losito, S., Pignata, S., Grassi, M., Perrone, F., De Luca, A., Tambaro, R., Bianco, C., Gullick, W. J., Johnson, G. R., Iaffaioli, V. R., Salomon, D. S., Normanno, N."Transforming growth factor α, amphiregulin and cripto-1 are frequently expressed in advanced human ovarian carcinomas". International Journal of Oncology 21, no. 5 (2002): 941-948. https://doi.org/10.3892/ijo.21.5.941
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