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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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December 2002 Volume 21 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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December 2002 Volume 21 Issue 6

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Article

Thrombospondin-1 expression as a prognostic predictor of pancreatic ductal carcinoma

  • Authors:
    • Kosuke Tobita
    • Hiroshi Kijima
    • Shoichi Dowaki
    • Yasuhisa Oida
    • Hiroyuki Kashiwagi
    • Masanori Ishii
    • Yoshinori Sugio
    • Takafumi Sekka
    • Yasuo Ohtani
    • Makiko Tanaka
    • Sadaki Inokuchi
    • Hiroyasu Makuuchi

  • View Affiliations / Copyright

    Affiliations: Department of Surgery, Tokai University School of Medicine, Bohseidai, Isehara, Kanagawa 259-1193, Japan
  • Pages: 1189-1195
    |
    Published online on: December 1, 2002
       https://doi.org/10.3892/ijo.21.6.1189
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Abstract

Pancreatic cancer is a malignant tumor with an extremely poor prognosis. Thrombospondin-1 (TSP-1) was suggested to be a potential regulator of tumor growth and metastasis. We examined TSP-1 expression in 77 cases of invasive ductal adenocarcinoma of the pancreas, and analyzed the correlation between the TSP-1 expression pattern and clinicopathological features in pancreatic cancer. TSP-1 immunoreactivity was detected in the cancer stroma. The diffusely positive and focally positive patterns of TSP-1 were found in 33 (42.9%) and 40 (51.9%) of 77 cases, respectively. The TSP-1 diffuse expression was significantly correlated with lymph node metastasis (p<0.01), neural invasion (p<0.05) and TNM stage (p<0.01). The prognostic significance of clinicopathological parameters were analyzed by univariate and multivariate analysis using the log-rank test and the Cox proportional hazards model. Based on the univariate analysis, histological differentiation (p<0.01), lymphatic invasion (p<0.01), venous invasion (p<0.05), neural invasion (p<0.01), TNM stage (p<0.01) and TSP-1 expression (p<0.01) were significant parameters. These observations suggested that TSP-1 plays important roles in cancer cell growth and metastasis of human pancreatic cancer, and that stromal TSP-1 immunoreactivity is a good prognostic predictor of patients with pancreatic cancer.

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Copy and paste a formatted citation
Spandidos Publications style
Tobita K, Kijima H, Dowaki S, Oida Y, Kashiwagi H, Ishii M, Sugio Y, Sekka T, Ohtani Y, Tanaka M, Tanaka M, et al: Thrombospondin-1 expression as a prognostic predictor of pancreatic ductal carcinoma. Int J Oncol 21: 1189-1195, 2002.
APA
Tobita, K., Kijima, H., Dowaki, S., Oida, Y., Kashiwagi, H., Ishii, M. ... Makuuchi, H. (2002). Thrombospondin-1 expression as a prognostic predictor of pancreatic ductal carcinoma. International Journal of Oncology, 21, 1189-1195. https://doi.org/10.3892/ijo.21.6.1189
MLA
Tobita, K., Kijima, H., Dowaki, S., Oida, Y., Kashiwagi, H., Ishii, M., Sugio, Y., Sekka, T., Ohtani, Y., Tanaka, M., Inokuchi, S., Makuuchi, H."Thrombospondin-1 expression as a prognostic predictor of pancreatic ductal carcinoma". International Journal of Oncology 21.6 (2002): 1189-1195.
Chicago
Tobita, K., Kijima, H., Dowaki, S., Oida, Y., Kashiwagi, H., Ishii, M., Sugio, Y., Sekka, T., Ohtani, Y., Tanaka, M., Inokuchi, S., Makuuchi, H."Thrombospondin-1 expression as a prognostic predictor of pancreatic ductal carcinoma". International Journal of Oncology 21, no. 6 (2002): 1189-1195. https://doi.org/10.3892/ijo.21.6.1189
Copy and paste a formatted citation
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Spandidos Publications style
Tobita K, Kijima H, Dowaki S, Oida Y, Kashiwagi H, Ishii M, Sugio Y, Sekka T, Ohtani Y, Tanaka M, Tanaka M, et al: Thrombospondin-1 expression as a prognostic predictor of pancreatic ductal carcinoma. Int J Oncol 21: 1189-1195, 2002.
APA
Tobita, K., Kijima, H., Dowaki, S., Oida, Y., Kashiwagi, H., Ishii, M. ... Makuuchi, H. (2002). Thrombospondin-1 expression as a prognostic predictor of pancreatic ductal carcinoma. International Journal of Oncology, 21, 1189-1195. https://doi.org/10.3892/ijo.21.6.1189
MLA
Tobita, K., Kijima, H., Dowaki, S., Oida, Y., Kashiwagi, H., Ishii, M., Sugio, Y., Sekka, T., Ohtani, Y., Tanaka, M., Inokuchi, S., Makuuchi, H."Thrombospondin-1 expression as a prognostic predictor of pancreatic ductal carcinoma". International Journal of Oncology 21.6 (2002): 1189-1195.
Chicago
Tobita, K., Kijima, H., Dowaki, S., Oida, Y., Kashiwagi, H., Ishii, M., Sugio, Y., Sekka, T., Ohtani, Y., Tanaka, M., Inokuchi, S., Makuuchi, H."Thrombospondin-1 expression as a prognostic predictor of pancreatic ductal carcinoma". International Journal of Oncology 21, no. 6 (2002): 1189-1195. https://doi.org/10.3892/ijo.21.6.1189
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