Thrombospondin-1 expression as a prognostic predictor of pancreatic ductal carcinoma

  • Authors:
    • Kosuke Tobita
    • Hiroshi Kijima
    • Shoichi Dowaki
    • Yasuhisa Oida
    • Hiroyuki Kashiwagi
    • Masanori Ishii
    • Yoshinori Sugio
    • Takafumi Sekka
    • Yasuo Ohtani
    • Makiko Tanaka
    • Sadaki Inokuchi
    • Hiroyasu Makuuchi
  • View Affiliations

  • Published online on: December 1, 2002     https://doi.org/10.3892/ijo.21.6.1189
  • Pages: 1189-1195
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Abstract

Pancreatic cancer is a malignant tumor with an extremely poor prognosis. Thrombospondin-1 (TSP-1) was suggested to be a potential regulator of tumor growth and metastasis. We examined TSP-1 expression in 77 cases of invasive ductal adenocarcinoma of the pancreas, and analyzed the correlation between the TSP-1 expression pattern and clinicopathological features in pancreatic cancer. TSP-1 immunoreactivity was detected in the cancer stroma. The diffusely positive and focally positive patterns of TSP-1 were found in 33 (42.9%) and 40 (51.9%) of 77 cases, respectively. The TSP-1 diffuse expression was significantly correlated with lymph node metastasis (p<0.01), neural invasion (p<0.05) and TNM stage (p<0.01). The prognostic significance of clinicopathological parameters were analyzed by univariate and multivariate analysis using the log-rank test and the Cox proportional hazards model. Based on the univariate analysis, histological differentiation (p<0.01), lymphatic invasion (p<0.01), venous invasion (p<0.05), neural invasion (p<0.01), TNM stage (p<0.01) and TSP-1 expression (p<0.01) were significant parameters. These observations suggested that TSP-1 plays important roles in cancer cell growth and metastasis of human pancreatic cancer, and that stromal TSP-1 immunoreactivity is a good prognostic predictor of patients with pancreatic cancer.

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December 2002
Volume 21 Issue 6

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Tobita K, Kijima H, Dowaki S, Oida Y, Kashiwagi H, Ishii M, Sugio Y, Sekka T, Ohtani Y, Tanaka M, Tanaka M, et al: Thrombospondin-1 expression as a prognostic predictor of pancreatic ductal carcinoma. Int J Oncol 21: 1189-1195, 2002
APA
Tobita, K., Kijima, H., Dowaki, S., Oida, Y., Kashiwagi, H., Ishii, M. ... Makuuchi, H. (2002). Thrombospondin-1 expression as a prognostic predictor of pancreatic ductal carcinoma. International Journal of Oncology, 21, 1189-1195. https://doi.org/10.3892/ijo.21.6.1189
MLA
Tobita, K., Kijima, H., Dowaki, S., Oida, Y., Kashiwagi, H., Ishii, M., Sugio, Y., Sekka, T., Ohtani, Y., Tanaka, M., Inokuchi, S., Makuuchi, H."Thrombospondin-1 expression as a prognostic predictor of pancreatic ductal carcinoma". International Journal of Oncology 21.6 (2002): 1189-1195.
Chicago
Tobita, K., Kijima, H., Dowaki, S., Oida, Y., Kashiwagi, H., Ishii, M., Sugio, Y., Sekka, T., Ohtani, Y., Tanaka, M., Inokuchi, S., Makuuchi, H."Thrombospondin-1 expression as a prognostic predictor of pancreatic ductal carcinoma". International Journal of Oncology 21, no. 6 (2002): 1189-1195. https://doi.org/10.3892/ijo.21.6.1189