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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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December 2002 Volume 21 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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December 2002 Volume 21 Issue 6

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Article

Tetrandrine-induced cell cycle arrest and apoptosis in A549 human lung carcinoma cells

  • Authors:
    • Jun Hyuk Lee
    • Gyung Hwa Kang
    • Kyung Chul Kim
    • Kyoung Mi Kim
    • Dong Il Park
    • Byung Tae Choi
    • Ho Sung Kang
    • Yong Tae Lee
    • Yung Hyun Choi

  • View Affiliations / Copyright

    Affiliations: Department of Oriental Medicine, Dongeui University College of Oriental Medicine and Research Institute of Oriental Medicine, Busan 614-052, Korea
  • Pages: 1239-1244
    |
    Published online on: December 1, 2002
       https://doi.org/10.3892/ijo.21.6.1239
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Abstract

Tetrandrine, isolated from the root of Stephania tetrandra, has been used in Chinese medicine for the treatment of silicosis and arthritis, and it also has anti-tumor/growth activities. However, the signaling pathways of tetrandrine-induced growth arrest and apoptosis in cancer cells remain unclear. We investigated the molecular mechanisms of tetrandrine-induced apoptosis and growth arrest in human lung carcinoma cells. Upon treatment with tetrandrine, a time-dependent inhibition of cell growth was observed and cells developed many of the hallmark features of apoptosis. Flow cytometry analysis confirmed that tetrandrine increased populations of both apoptotic sub-G1 and G1 phase. Tetrandrine-induced growth inhibition was associated with induction of Cdk inhibitor p21, inhibition of cyclin D1 and activation of caspase-3. Tetrandrine also affected the expression patterns of cytoskeletons including distribution of F-actin and expression level of microtubule. These results suggest that tetrandrine merits further investigation as a cell cycle blocker as well as a cancer chemopreventive agent.

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Copy and paste a formatted citation
Spandidos Publications style
Lee JH, Kang GH, Kim KC, Kim KM, Park DI, Choi BT, Kang HS, Lee YT and Choi YH: Tetrandrine-induced cell cycle arrest and apoptosis in A549 human lung carcinoma cells. Int J Oncol 21: 1239-1244, 2002.
APA
Lee, J.H., Kang, G.H., Kim, K.C., Kim, K.M., Park, D.I., Choi, B.T. ... Choi, Y.H. (2002). Tetrandrine-induced cell cycle arrest and apoptosis in A549 human lung carcinoma cells. International Journal of Oncology, 21, 1239-1244. https://doi.org/10.3892/ijo.21.6.1239
MLA
Lee, J. H., Kang, G. H., Kim, K. C., Kim, K. M., Park, D. I., Choi, B. T., Kang, H. S., Lee, Y. T., Choi, Y. H."Tetrandrine-induced cell cycle arrest and apoptosis in A549 human lung carcinoma cells". International Journal of Oncology 21.6 (2002): 1239-1244.
Chicago
Lee, J. H., Kang, G. H., Kim, K. C., Kim, K. M., Park, D. I., Choi, B. T., Kang, H. S., Lee, Y. T., Choi, Y. H."Tetrandrine-induced cell cycle arrest and apoptosis in A549 human lung carcinoma cells". International Journal of Oncology 21, no. 6 (2002): 1239-1244. https://doi.org/10.3892/ijo.21.6.1239
Copy and paste a formatted citation
x
Spandidos Publications style
Lee JH, Kang GH, Kim KC, Kim KM, Park DI, Choi BT, Kang HS, Lee YT and Choi YH: Tetrandrine-induced cell cycle arrest and apoptosis in A549 human lung carcinoma cells. Int J Oncol 21: 1239-1244, 2002.
APA
Lee, J.H., Kang, G.H., Kim, K.C., Kim, K.M., Park, D.I., Choi, B.T. ... Choi, Y.H. (2002). Tetrandrine-induced cell cycle arrest and apoptosis in A549 human lung carcinoma cells. International Journal of Oncology, 21, 1239-1244. https://doi.org/10.3892/ijo.21.6.1239
MLA
Lee, J. H., Kang, G. H., Kim, K. C., Kim, K. M., Park, D. I., Choi, B. T., Kang, H. S., Lee, Y. T., Choi, Y. H."Tetrandrine-induced cell cycle arrest and apoptosis in A549 human lung carcinoma cells". International Journal of Oncology 21.6 (2002): 1239-1244.
Chicago
Lee, J. H., Kang, G. H., Kim, K. C., Kim, K. M., Park, D. I., Choi, B. T., Kang, H. S., Lee, Y. T., Choi, Y. H."Tetrandrine-induced cell cycle arrest and apoptosis in A549 human lung carcinoma cells". International Journal of Oncology 21, no. 6 (2002): 1239-1244. https://doi.org/10.3892/ijo.21.6.1239
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