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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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January 2003 Volume 22 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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January 2003 Volume 22 Issue 1

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Review

Simian virus 40 and malignant mesothelioma (Review)

  • Authors:
    • Paolo Giuseppe Cerrano
    • Bharat Jasani
    • Rosangela Filiberti
    • Monica Neri
    • Franco Merlo
    • Silvio De Flora
    • Luciano Mutti
    • Riccardo Puntoni

  • View Affiliations / Copyright

    Affiliations: Department of Health Sciences, University of Genoa, I-16132 Genoa, Italy
  • Pages: 187-194
    |
    Published online on: January 1, 2003
       https://doi.org/10.3892/ijo.22.1.187
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Abstract

Simian virus 40 (SV40) was recognized as a contaminant of early poliovirus vaccines that were provided to millions of individuals in Europe and in the USA between 1955 and 1963. SV40, a DNA virus of the family of papovaviridae, was proven to be oncogenic in rodents and able to transform human and animal cells in vitro. In 1993 SV40 was accidentally discovered to produce mesotheliomas in hamsters when it was injected in visceral cavities. Afterwards, SV40 DNA sequences were detected with significative frequency in human pleural mesotheliomas by using polymerase chain reaction (PCR) and then SV40 DNA oncogenicity was associated with its large T antigen (Tag). This finding was confirmed by many laboratories, while a few research groups failed to replicate these data and argued that the SV40 DNA detection might be a PCR contamination artefact. In this review the dispute is examined in the light of recent experiments performed to identify molecular and cellular aspects of carcinogenicity and/or co-carcinogenicity of SV40 in human mesothelioma.

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Copy and paste a formatted citation
Spandidos Publications style
Cerrano PG, Jasani B, Filiberti R, Neri M, Merlo F, De Flora S, Mutti L and Puntoni R: Simian virus 40 and malignant mesothelioma (Review). Int J Oncol 22: 187-194, 2003.
APA
Cerrano, P.G., Jasani, B., Filiberti, R., Neri, M., Merlo, F., De Flora, S. ... Puntoni, R. (2003). Simian virus 40 and malignant mesothelioma (Review). International Journal of Oncology, 22, 187-194. https://doi.org/10.3892/ijo.22.1.187
MLA
Cerrano, P. G., Jasani, B., Filiberti, R., Neri, M., Merlo, F., De Flora, S., Mutti, L., Puntoni, R."Simian virus 40 and malignant mesothelioma (Review)". International Journal of Oncology 22.1 (2003): 187-194.
Chicago
Cerrano, P. G., Jasani, B., Filiberti, R., Neri, M., Merlo, F., De Flora, S., Mutti, L., Puntoni, R."Simian virus 40 and malignant mesothelioma (Review)". International Journal of Oncology 22, no. 1 (2003): 187-194. https://doi.org/10.3892/ijo.22.1.187
Copy and paste a formatted citation
x
Spandidos Publications style
Cerrano PG, Jasani B, Filiberti R, Neri M, Merlo F, De Flora S, Mutti L and Puntoni R: Simian virus 40 and malignant mesothelioma (Review). Int J Oncol 22: 187-194, 2003.
APA
Cerrano, P.G., Jasani, B., Filiberti, R., Neri, M., Merlo, F., De Flora, S. ... Puntoni, R. (2003). Simian virus 40 and malignant mesothelioma (Review). International Journal of Oncology, 22, 187-194. https://doi.org/10.3892/ijo.22.1.187
MLA
Cerrano, P. G., Jasani, B., Filiberti, R., Neri, M., Merlo, F., De Flora, S., Mutti, L., Puntoni, R."Simian virus 40 and malignant mesothelioma (Review)". International Journal of Oncology 22.1 (2003): 187-194.
Chicago
Cerrano, P. G., Jasani, B., Filiberti, R., Neri, M., Merlo, F., De Flora, S., Mutti, L., Puntoni, R."Simian virus 40 and malignant mesothelioma (Review)". International Journal of Oncology 22, no. 1 (2003): 187-194. https://doi.org/10.3892/ijo.22.1.187
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