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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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January 2003 Volume 22 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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January 2003 Volume 22 Issue 1

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Article

Constitutive expression of cytotoxic proteases and down-regulation of protease inhibitors in LGL leukemia

  • Authors:
    • Ravi Kothapalli
    • Ratna D. Bailey
    • Irina Kusmartseva
    • Shrikant Mane
    • P. K. Epling-Burnette
    • Thomas P. Loughran

  • View Affiliations / Copyright

    Affiliations: H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA. kothapar@moffitt.usf.edu
  • Pages: 33-39
    |
    Published online on: January 1, 2003
       https://doi.org/10.3892/ijo.22.1.33
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Abstract

Large granular lymphocyte (LGL) leukemia is a lymphoproliferative disorder often associated with rheumatoid arthritis. The etiology of LGL leukemia is not known. In order to better understand the pathogenesis of LGL leukemia, we analyzed differential gene expression using microarray technology. We found that approximately 80 genes were up-regulated and 12 genes were down-regulated when compared to normal peripheral blood mononuclear cells (PBMC). In the present study, we were interested in a group of genes involved in cytotoxic function. The up-regulated genes involved in cytotoxic function were serine proteinases (granzymes A, B, H and K) cysteine proteinases [cathepsin C, cathepsin W (lymphopain)], calpain small subunit and caspase-8. In addition, a pore-forming protein perforin, was also up-regulated. Northern blot analysis and RNase protection assays (RPA) confirmed that these genes were over-expressed in the majority of samples from LGL leukemia patients. Of interest, proteolytic inhibitors such as cystatin C, A, α-1 antitrypsin and metalloproteinase inhibitors were down-regulated in leukemic LGL when compared to normal peripheral blood mononuclear cells. Importantly, the pattern of gene expression in leukemic LGL resembles that seen in activated cytotoxic T cells (CTL).

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Copy and paste a formatted citation
Spandidos Publications style
Kothapalli R, Bailey RD, Kusmartseva I, Mane S, Epling-Burnette PK and Loughran TP: Constitutive expression of cytotoxic proteases and down-regulation of protease inhibitors in LGL leukemia. Int J Oncol 22: 33-39, 2003.
APA
Kothapalli, R., Bailey, R.D., Kusmartseva, I., Mane, S., Epling-Burnette, P.K., & Loughran, T.P. (2003). Constitutive expression of cytotoxic proteases and down-regulation of protease inhibitors in LGL leukemia. International Journal of Oncology, 22, 33-39. https://doi.org/10.3892/ijo.22.1.33
MLA
Kothapalli, R., Bailey, R. D., Kusmartseva, I., Mane, S., Epling-Burnette, P. K., Loughran, T. P."Constitutive expression of cytotoxic proteases and down-regulation of protease inhibitors in LGL leukemia". International Journal of Oncology 22.1 (2003): 33-39.
Chicago
Kothapalli, R., Bailey, R. D., Kusmartseva, I., Mane, S., Epling-Burnette, P. K., Loughran, T. P."Constitutive expression of cytotoxic proteases and down-regulation of protease inhibitors in LGL leukemia". International Journal of Oncology 22, no. 1 (2003): 33-39. https://doi.org/10.3892/ijo.22.1.33
Copy and paste a formatted citation
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Spandidos Publications style
Kothapalli R, Bailey RD, Kusmartseva I, Mane S, Epling-Burnette PK and Loughran TP: Constitutive expression of cytotoxic proteases and down-regulation of protease inhibitors in LGL leukemia. Int J Oncol 22: 33-39, 2003.
APA
Kothapalli, R., Bailey, R.D., Kusmartseva, I., Mane, S., Epling-Burnette, P.K., & Loughran, T.P. (2003). Constitutive expression of cytotoxic proteases and down-regulation of protease inhibitors in LGL leukemia. International Journal of Oncology, 22, 33-39. https://doi.org/10.3892/ijo.22.1.33
MLA
Kothapalli, R., Bailey, R. D., Kusmartseva, I., Mane, S., Epling-Burnette, P. K., Loughran, T. P."Constitutive expression of cytotoxic proteases and down-regulation of protease inhibitors in LGL leukemia". International Journal of Oncology 22.1 (2003): 33-39.
Chicago
Kothapalli, R., Bailey, R. D., Kusmartseva, I., Mane, S., Epling-Burnette, P. K., Loughran, T. P."Constitutive expression of cytotoxic proteases and down-regulation of protease inhibitors in LGL leukemia". International Journal of Oncology 22, no. 1 (2003): 33-39. https://doi.org/10.3892/ijo.22.1.33
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