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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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January 2003 Volume 22 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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January 2003 Volume 22 Issue 1

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Article

Restoration of p53 gene function in 12-O-tetradecanoylphorbor 13-acetate-resistant human leukemia K562/TPA cells

  • Authors:
    • Jitsuo Usuda
    • Motoko Inomata
    • Hisao Fukumoto
    • Yasuo Iwamoto
    • Toshihiro Suzuki
    • Hyo-Jeong Kuh
    • Kazuya Fukuoka
    • Harubumi Kato
    • Nagahiro Saijo
    • Kazuto Nishio

  • View Affiliations / Copyright

    Affiliations: Pharmacology Division, National Cancer Center Research Institute, Tokyo 104-0045, Japan
  • Pages: 81-86
    |
    Published online on: January 1, 2003
       https://doi.org/10.3892/ijo.22.1.81
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Abstract

The human leukemia K562 cell line does not express wild-type p53 protein. Due to the loss of one p53 allele and an insertion mutation in exon 5 of the other allele resulting in a frameshift mutation, K562 cells express a truncated p53 protein of 148 amino acids. A human leukemia phorbol ester-resistant subline, K562/TPA, is cross-resistant to some anticancer agents. A remarkable difference in cell cycle progression at G1/S phase was observed in the synchronised K562/TPA cells as compared with K562 cells. Southern blot and DNA sequence analysis revealed no mutation in exon 5 of the p53 gene in K562/TPA cells. p21Cip1 expression was also restored in K562/TPA cells confirming that the reversal of this p53 gene mutation restored wild-type p53 function in these cells. This is a unique report describing reversal of p53 gene mutation by drugs. This was associated with the expression of wild-type p53 mRNA and protein in K562/TPA cells. The K562/TPA cell line may provide a very useful tool for the investigation of the relationship between p53 status and chemosensitization.

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Copy and paste a formatted citation
Spandidos Publications style
Usuda J, Inomata M, Fukumoto H, Iwamoto Y, Suzuki T, Kuh H, Fukuoka K, Kato H, Saijo N, Nishio K, Nishio K, et al: Restoration of p53 gene function in 12-O-tetradecanoylphorbor 13-acetate-resistant human leukemia K562/TPA cells. Int J Oncol 22: 81-86, 2003.
APA
Usuda, J., Inomata, M., Fukumoto, H., Iwamoto, Y., Suzuki, T., Kuh, H. ... Nishio, K. (2003). Restoration of p53 gene function in 12-O-tetradecanoylphorbor 13-acetate-resistant human leukemia K562/TPA cells. International Journal of Oncology, 22, 81-86. https://doi.org/10.3892/ijo.22.1.81
MLA
Usuda, J., Inomata, M., Fukumoto, H., Iwamoto, Y., Suzuki, T., Kuh, H., Fukuoka, K., Kato, H., Saijo, N., Nishio, K."Restoration of p53 gene function in 12-O-tetradecanoylphorbor 13-acetate-resistant human leukemia K562/TPA cells". International Journal of Oncology 22.1 (2003): 81-86.
Chicago
Usuda, J., Inomata, M., Fukumoto, H., Iwamoto, Y., Suzuki, T., Kuh, H., Fukuoka, K., Kato, H., Saijo, N., Nishio, K."Restoration of p53 gene function in 12-O-tetradecanoylphorbor 13-acetate-resistant human leukemia K562/TPA cells". International Journal of Oncology 22, no. 1 (2003): 81-86. https://doi.org/10.3892/ijo.22.1.81
Copy and paste a formatted citation
x
Spandidos Publications style
Usuda J, Inomata M, Fukumoto H, Iwamoto Y, Suzuki T, Kuh H, Fukuoka K, Kato H, Saijo N, Nishio K, Nishio K, et al: Restoration of p53 gene function in 12-O-tetradecanoylphorbor 13-acetate-resistant human leukemia K562/TPA cells. Int J Oncol 22: 81-86, 2003.
APA
Usuda, J., Inomata, M., Fukumoto, H., Iwamoto, Y., Suzuki, T., Kuh, H. ... Nishio, K. (2003). Restoration of p53 gene function in 12-O-tetradecanoylphorbor 13-acetate-resistant human leukemia K562/TPA cells. International Journal of Oncology, 22, 81-86. https://doi.org/10.3892/ijo.22.1.81
MLA
Usuda, J., Inomata, M., Fukumoto, H., Iwamoto, Y., Suzuki, T., Kuh, H., Fukuoka, K., Kato, H., Saijo, N., Nishio, K."Restoration of p53 gene function in 12-O-tetradecanoylphorbor 13-acetate-resistant human leukemia K562/TPA cells". International Journal of Oncology 22.1 (2003): 81-86.
Chicago
Usuda, J., Inomata, M., Fukumoto, H., Iwamoto, Y., Suzuki, T., Kuh, H., Fukuoka, K., Kato, H., Saijo, N., Nishio, K."Restoration of p53 gene function in 12-O-tetradecanoylphorbor 13-acetate-resistant human leukemia K562/TPA cells". International Journal of Oncology 22, no. 1 (2003): 81-86. https://doi.org/10.3892/ijo.22.1.81
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