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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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February 2003 Volume 22 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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February 2003 Volume 22 Issue 2

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Article

Expression of proteinase-activated receptor-2 in human pancreatic cancer: A possible relation to cancer invasion and induction of fibrosis

  • Authors:
    • Osamu Ikeda
    • Hiroshi Egami
    • Takatoshi Ishiko
    • Shinji Ishikawa
    • Hidenobu Kamohara
    • Hideki Hidaka
    • Seiji Mita
    • Michio Ogawa

  • View Affiliations / Copyright

    Affiliations: Department of Surgery II, Kumamoto University Medical School, Kumamoto, Japan
  • Pages: 295-300
    |
    Published online on: February 1, 2003
       https://doi.org/10.3892/ijo.22.2.295
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Abstract

The proteinase-activated receptor-2 (PAR-2) is a G protein-coupled receptor that is cleaved and activated by trypsin. To clarify the presence of PAR-2 in human pancreatic cancer, the expression of PAR-2 was analyzed by RT-PCR, immunoblotting and immunocytochemistry using 5 human pancreatic cancer cell lines. And to evaluate the biological significance, immunohistochemical expression of PAR-2 in malignant and non-malignant human pancreatic tissues was examined using paraffin-embedded sections. The presence of PAR-2 was confirmed in all 5 pancreatic cancer cell lines and all 21 paraffin-embedded specimens from human pancreatic cancer examined. The expression of PAR-2 was found to be higher in the tissues with infiltrative growth pattern than those with expansive growth pattern. Moreover, significantly higher expression of PAR-2 was observed in the tissues which were accompanied by severe fibrosis. Even in the same specimen, the intensity of immunoreactivity tended to be stronger in the part with severe fibrosis than that with mild fibrosis. Similarly, the higher expression of PAR-2 was observed in chronic pancreatitis with severe fibrosis than with mild fibrosis. Taken together, these results suggest that the activation of PAR-2 is involved in cancer invasion and the induction of fibrosis in human pancreatic cancer.

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Copy and paste a formatted citation
Spandidos Publications style
Ikeda O, Egami H, Ishiko T, Ishikawa S, Kamohara H, Hidaka H, Mita S and Ogawa M: Expression of proteinase-activated receptor-2 in human pancreatic cancer: A possible relation to cancer invasion and induction of fibrosis. Int J Oncol 22: 295-300, 2003.
APA
Ikeda, O., Egami, H., Ishiko, T., Ishikawa, S., Kamohara, H., Hidaka, H. ... Ogawa, M. (2003). Expression of proteinase-activated receptor-2 in human pancreatic cancer: A possible relation to cancer invasion and induction of fibrosis. International Journal of Oncology, 22, 295-300. https://doi.org/10.3892/ijo.22.2.295
MLA
Ikeda, O., Egami, H., Ishiko, T., Ishikawa, S., Kamohara, H., Hidaka, H., Mita, S., Ogawa, M."Expression of proteinase-activated receptor-2 in human pancreatic cancer: A possible relation to cancer invasion and induction of fibrosis". International Journal of Oncology 22.2 (2003): 295-300.
Chicago
Ikeda, O., Egami, H., Ishiko, T., Ishikawa, S., Kamohara, H., Hidaka, H., Mita, S., Ogawa, M."Expression of proteinase-activated receptor-2 in human pancreatic cancer: A possible relation to cancer invasion and induction of fibrosis". International Journal of Oncology 22, no. 2 (2003): 295-300. https://doi.org/10.3892/ijo.22.2.295
Copy and paste a formatted citation
x
Spandidos Publications style
Ikeda O, Egami H, Ishiko T, Ishikawa S, Kamohara H, Hidaka H, Mita S and Ogawa M: Expression of proteinase-activated receptor-2 in human pancreatic cancer: A possible relation to cancer invasion and induction of fibrosis. Int J Oncol 22: 295-300, 2003.
APA
Ikeda, O., Egami, H., Ishiko, T., Ishikawa, S., Kamohara, H., Hidaka, H. ... Ogawa, M. (2003). Expression of proteinase-activated receptor-2 in human pancreatic cancer: A possible relation to cancer invasion and induction of fibrosis. International Journal of Oncology, 22, 295-300. https://doi.org/10.3892/ijo.22.2.295
MLA
Ikeda, O., Egami, H., Ishiko, T., Ishikawa, S., Kamohara, H., Hidaka, H., Mita, S., Ogawa, M."Expression of proteinase-activated receptor-2 in human pancreatic cancer: A possible relation to cancer invasion and induction of fibrosis". International Journal of Oncology 22.2 (2003): 295-300.
Chicago
Ikeda, O., Egami, H., Ishiko, T., Ishikawa, S., Kamohara, H., Hidaka, H., Mita, S., Ogawa, M."Expression of proteinase-activated receptor-2 in human pancreatic cancer: A possible relation to cancer invasion and induction of fibrosis". International Journal of Oncology 22, no. 2 (2003): 295-300. https://doi.org/10.3892/ijo.22.2.295
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