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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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February 2003 Volume 22 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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February 2003 Volume 22 Issue 2

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Article

Monensin-mediated growth inhibition of SNU-C1 colon cancer cells via cell cycle arrest and apoptosis

  • Authors:
    • Woo Hyun Park
    • Eun Shil Kim
    • Chul Won Jung
    • Byoung Kook Kim
    • Young Yiul Lee

  • View Affiliations / Copyright

    Affiliations: Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea
  • Pages: 377-382
    |
    Published online on: February 1, 2003
       https://doi.org/10.3892/ijo.22.2.377
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Abstract

Previously, we showed that monensin, Na+ ionophore, potently inhibited the growth of acute myelogenous leukemia and lymphoma cells. Here, we demonstrate that monensin inhibited the proliferation of solid tumor cells with IC50 of about 2.5 µM. Monensin induced a G1 or a G2-M phase arrest in these cells. When we examined the effects of this drug on SNU-C1 cells, monensin decreased the levels of CDK2, CDK4, CDK6, cyclin D1 and cyclin A proteins. While p27 was increased by monensin, p21 was not. In addition, monensin markedly enhanced the binding of p27 with CDK2, CDK4 and CDK6. Furthermore, the activities of CDK2-, CDK4- and CDK6-associated kinase were reduced in association with hypophosphorylation of Rb protein. Monensin also induced apoptosis in solid tumor cells. Apoptotic process of SNU-C1 cells was associated with the changes of Bax, caspase-3 and mitochondria transmembrane potential (ΔΨm). Taken together, these results demonstrated for the first time that monensin inhibited the growth of solid tumor cells, especially SNU-C1 cells, via cell cycle arrest and apoptosis.

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Copy and paste a formatted citation
Spandidos Publications style
Park WH, Kim ES, Jung CW, Kim BK and Lee YY: Monensin-mediated growth inhibition of SNU-C1 colon cancer cells via cell cycle arrest and apoptosis. Int J Oncol 22: 377-382, 2003.
APA
Park, W.H., Kim, E.S., Jung, C.W., Kim, B.K., & Lee, Y.Y. (2003). Monensin-mediated growth inhibition of SNU-C1 colon cancer cells via cell cycle arrest and apoptosis. International Journal of Oncology, 22, 377-382. https://doi.org/10.3892/ijo.22.2.377
MLA
Park, W. H., Kim, E. S., Jung, C. W., Kim, B. K., Lee, Y. Y."Monensin-mediated growth inhibition of SNU-C1 colon cancer cells via cell cycle arrest and apoptosis". International Journal of Oncology 22.2 (2003): 377-382.
Chicago
Park, W. H., Kim, E. S., Jung, C. W., Kim, B. K., Lee, Y. Y."Monensin-mediated growth inhibition of SNU-C1 colon cancer cells via cell cycle arrest and apoptosis". International Journal of Oncology 22, no. 2 (2003): 377-382. https://doi.org/10.3892/ijo.22.2.377
Copy and paste a formatted citation
x
Spandidos Publications style
Park WH, Kim ES, Jung CW, Kim BK and Lee YY: Monensin-mediated growth inhibition of SNU-C1 colon cancer cells via cell cycle arrest and apoptosis. Int J Oncol 22: 377-382, 2003.
APA
Park, W.H., Kim, E.S., Jung, C.W., Kim, B.K., & Lee, Y.Y. (2003). Monensin-mediated growth inhibition of SNU-C1 colon cancer cells via cell cycle arrest and apoptosis. International Journal of Oncology, 22, 377-382. https://doi.org/10.3892/ijo.22.2.377
MLA
Park, W. H., Kim, E. S., Jung, C. W., Kim, B. K., Lee, Y. Y."Monensin-mediated growth inhibition of SNU-C1 colon cancer cells via cell cycle arrest and apoptosis". International Journal of Oncology 22.2 (2003): 377-382.
Chicago
Park, W. H., Kim, E. S., Jung, C. W., Kim, B. K., Lee, Y. Y."Monensin-mediated growth inhibition of SNU-C1 colon cancer cells via cell cycle arrest and apoptosis". International Journal of Oncology 22, no. 2 (2003): 377-382. https://doi.org/10.3892/ijo.22.2.377
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