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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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April 2003 Volume 22 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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April 2003 Volume 22 Issue 4

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Article

Protein kinase Cα regulates Ets1 transcriptional activity in invasive breast cancer cells

  • Authors:
    • Ralph K. Lindemann
    • Melanie Braig
    • Pia Ballschmieter
    • Theresa A. Guise
    • Alfred Nordheim
    • Jürgen Dittmer

  • View Affiliations / Copyright

    Affiliations: u Institut für Zellbiologie, Abteilung Molekularbiologie, Universität Tübingen, D-72076 Tübingen, Germany
  • Pages: 799-805
    |
    Published online on: April 1, 2003
       https://doi.org/10.3892/ijo.22.4.799
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Abstract

We have previously shown that PKC inhibitors interfere with the Ets1/Smad3-dependent regulation of parathyroid hormone-related protein (PTHrP) P3 promoter activity by TGFβ in invasive MDA-MB-231 breast cancer cells. By examining PKC expression in a variety of breast cancer cell lines, the protein level of PKCα was found to be much higher in Ets1-expressing MDA-MB-231 and MDA-MB-435 breast cancer cells than in Ets1-deficient MCF-7 and SK-BR3 cells. No correlation of Ets1 expression with the expression of other PKC subtypes (PKCβ1, PKCβ2, PKCδ or PKCε) could be observed. In contrast to MDA-MB-231 cells, PKCα-deficient MCF-7 cells do not support Ets1-induced activation of the PTHrP P3 promoter suggesting that PKCα may be important for Ets1 activity. A constitutively active form of PKCα was found to potentiate the P3 promoter activation by Ets1 alone and in synergy with Smad3. PKCα, but not PKCε, also induced phosphorylation of the Ets1 protein. Both PKCα effects on Ets1 depended on the exon VII domain of Ets1. Using verapamil and ionomycin, we could show that PKCα induces Ets1 phosphorylation independent of calcium mobilization. Collectively, our data suggest that PKCα may regulate Ets1 activity in invasive breast cancer cells.

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Copy and paste a formatted citation
Spandidos Publications style
Lindemann RK, Braig M, Ballschmieter P, Guise TA, Nordheim A and Dittmer J: Protein kinase Cα regulates Ets1 transcriptional activity in invasive breast cancer cells. Int J Oncol 22: 799-805, 2003.
APA
Lindemann, R.K., Braig, M., Ballschmieter, P., Guise, T.A., Nordheim, A., & Dittmer, J. (2003). Protein kinase Cα regulates Ets1 transcriptional activity in invasive breast cancer cells. International Journal of Oncology, 22, 799-805. https://doi.org/10.3892/ijo.22.4.799
MLA
Lindemann, R. K., Braig, M., Ballschmieter, P., Guise, T. A., Nordheim, A., Dittmer, J."Protein kinase Cα regulates Ets1 transcriptional activity in invasive breast cancer cells". International Journal of Oncology 22.4 (2003): 799-805.
Chicago
Lindemann, R. K., Braig, M., Ballschmieter, P., Guise, T. A., Nordheim, A., Dittmer, J."Protein kinase Cα regulates Ets1 transcriptional activity in invasive breast cancer cells". International Journal of Oncology 22, no. 4 (2003): 799-805. https://doi.org/10.3892/ijo.22.4.799
Copy and paste a formatted citation
x
Spandidos Publications style
Lindemann RK, Braig M, Ballschmieter P, Guise TA, Nordheim A and Dittmer J: Protein kinase Cα regulates Ets1 transcriptional activity in invasive breast cancer cells. Int J Oncol 22: 799-805, 2003.
APA
Lindemann, R.K., Braig, M., Ballschmieter, P., Guise, T.A., Nordheim, A., & Dittmer, J. (2003). Protein kinase Cα regulates Ets1 transcriptional activity in invasive breast cancer cells. International Journal of Oncology, 22, 799-805. https://doi.org/10.3892/ijo.22.4.799
MLA
Lindemann, R. K., Braig, M., Ballschmieter, P., Guise, T. A., Nordheim, A., Dittmer, J."Protein kinase Cα regulates Ets1 transcriptional activity in invasive breast cancer cells". International Journal of Oncology 22.4 (2003): 799-805.
Chicago
Lindemann, R. K., Braig, M., Ballschmieter, P., Guise, T. A., Nordheim, A., Dittmer, J."Protein kinase Cα regulates Ets1 transcriptional activity in invasive breast cancer cells". International Journal of Oncology 22, no. 4 (2003): 799-805. https://doi.org/10.3892/ijo.22.4.799
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