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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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May 2003 Volume 22 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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May 2003 Volume 22 Issue 5

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Article

Elimination of CD4+ T cells may overcome suppression of anti-HER2 immune responses in tumor-bearing hosts

  • Authors:
    • Mikiya Ishihara
    • Isao Tawara
    • Lijie Wang
    • Yoshiyuki Takahashi
    • Hiroshi Shiku

  • View Affiliations / Copyright

    Affiliations: Second Department of Internal Medicine, Mie University School of Medicine, Tsu 514-8507, Japan
  • Pages: 1135-1139
    |
    Published online on: May 1, 2003
       https://doi.org/10.3892/ijo.22.5.1135
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Abstract

In this study, we analyzed specific anti-tumor immune responses in tumor-bearing hosts by measuring HER2-specific CD8+ T cell responses. No measurable HER2-derived peptide (HER2p63)-specific CD8+ T cells were present in the spleens of mice in the early to late phase of tumor-bearing. Vaccination with HER2 protein and cholesteryl group-bearing pullulan (CHP-HER2 complex) induced HER2-specific CD8+ T cells, but their numbers continuously declined as tumors continued growing. Removal of CD4+ T cells by anti-CD4 monoclonal antibody in the early tumor-bearing stage resulted in tumor regression. The combination of CHP-HER2 complex vaccination and depletion of CD4+ T cells enhanced and restored HER2-specific CD8+ T cells in the late stage of tumor-bearing, and also suppressed tumor growth. These results indicate the importance of manipulation of CD4+ T cells in developing effective immunotherapies as cancer vaccines.

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Copy and paste a formatted citation
Spandidos Publications style
Ishihara M, Tawara I, Wang L, Takahashi Y and Shiku H: Elimination of CD4+ T cells may overcome suppression of anti-HER2 immune responses in tumor-bearing hosts. Int J Oncol 22: 1135-1139, 2003.
APA
Ishihara, M., Tawara, I., Wang, L., Takahashi, Y., & Shiku, H. (2003). Elimination of CD4+ T cells may overcome suppression of anti-HER2 immune responses in tumor-bearing hosts. International Journal of Oncology, 22, 1135-1139. https://doi.org/10.3892/ijo.22.5.1135
MLA
Ishihara, M., Tawara, I., Wang, L., Takahashi, Y., Shiku, H."Elimination of CD4+ T cells may overcome suppression of anti-HER2 immune responses in tumor-bearing hosts". International Journal of Oncology 22.5 (2003): 1135-1139.
Chicago
Ishihara, M., Tawara, I., Wang, L., Takahashi, Y., Shiku, H."Elimination of CD4+ T cells may overcome suppression of anti-HER2 immune responses in tumor-bearing hosts". International Journal of Oncology 22, no. 5 (2003): 1135-1139. https://doi.org/10.3892/ijo.22.5.1135
Copy and paste a formatted citation
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Spandidos Publications style
Ishihara M, Tawara I, Wang L, Takahashi Y and Shiku H: Elimination of CD4+ T cells may overcome suppression of anti-HER2 immune responses in tumor-bearing hosts. Int J Oncol 22: 1135-1139, 2003.
APA
Ishihara, M., Tawara, I., Wang, L., Takahashi, Y., & Shiku, H. (2003). Elimination of CD4+ T cells may overcome suppression of anti-HER2 immune responses in tumor-bearing hosts. International Journal of Oncology, 22, 1135-1139. https://doi.org/10.3892/ijo.22.5.1135
MLA
Ishihara, M., Tawara, I., Wang, L., Takahashi, Y., Shiku, H."Elimination of CD4+ T cells may overcome suppression of anti-HER2 immune responses in tumor-bearing hosts". International Journal of Oncology 22.5 (2003): 1135-1139.
Chicago
Ishihara, M., Tawara, I., Wang, L., Takahashi, Y., Shiku, H."Elimination of CD4+ T cells may overcome suppression of anti-HER2 immune responses in tumor-bearing hosts". International Journal of Oncology 22, no. 5 (2003): 1135-1139. https://doi.org/10.3892/ijo.22.5.1135
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