Elimination of CD4+ T cells may overcome suppression of anti-HER2 immune responses in tumor-bearing hosts

  • Authors:
    • Mikiya Ishihara
    • Isao Tawara
    • Lijie Wang
    • Yoshiyuki Takahashi
    • Hiroshi Shiku
  • View Affiliations

  • Published online on: May 1, 2003     https://doi.org/10.3892/ijo.22.5.1135
  • Pages: 1135-1139
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Abstract

In this study, we analyzed specific anti-tumor immune responses in tumor-bearing hosts by measuring HER2-specific CD8+ T cell responses. No measurable HER2-derived peptide (HER2p63)-specific CD8+ T cells were present in the spleens of mice in the early to late phase of tumor-bearing. Vaccination with HER2 protein and cholesteryl group-bearing pullulan (CHP-HER2 complex) induced HER2-specific CD8+ T cells, but their numbers continuously declined as tumors continued growing. Removal of CD4+ T cells by anti-CD4 monoclonal antibody in the early tumor-bearing stage resulted in tumor regression. The combination of CHP-HER2 complex vaccination and depletion of CD4+ T cells enhanced and restored HER2-specific CD8+ T cells in the late stage of tumor-bearing, and also suppressed tumor growth. These results indicate the importance of manipulation of CD4+ T cells in developing effective immunotherapies as cancer vaccines.

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May 2003
Volume 22 Issue 5

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Ishihara M, Tawara I, Wang L, Takahashi Y and Shiku H: Elimination of CD4+ T cells may overcome suppression of anti-HER2 immune responses in tumor-bearing hosts. Int J Oncol 22: 1135-1139, 2003.
APA
Ishihara, M., Tawara, I., Wang, L., Takahashi, Y., & Shiku, H. (2003). Elimination of CD4+ T cells may overcome suppression of anti-HER2 immune responses in tumor-bearing hosts. International Journal of Oncology, 22, 1135-1139. https://doi.org/10.3892/ijo.22.5.1135
MLA
Ishihara, M., Tawara, I., Wang, L., Takahashi, Y., Shiku, H."Elimination of CD4+ T cells may overcome suppression of anti-HER2 immune responses in tumor-bearing hosts". International Journal of Oncology 22.5 (2003): 1135-1139.
Chicago
Ishihara, M., Tawara, I., Wang, L., Takahashi, Y., Shiku, H."Elimination of CD4+ T cells may overcome suppression of anti-HER2 immune responses in tumor-bearing hosts". International Journal of Oncology 22, no. 5 (2003): 1135-1139. https://doi.org/10.3892/ijo.22.5.1135