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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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June 2003 Volume 22 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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June 2003 Volume 22 Issue 6

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Article

NADE (p75NTR-associated cell death executor) suppresses cellular growth in vivo

  • Authors:
    • Xiangjun Tong
    • Dong Xie
    • Wilfried Roth
    • John Reed
    • H. Phillip Koeffler

  • View Affiliations / Copyright

    Affiliations: Division of Hematology/Oncology, Cedars-Sinai Medical Center, UCLA School of Medicine, Los Angeles, CA 90048, USA
  • Pages: 1357-1362
    |
    Published online on: June 1, 2003
       https://doi.org/10.3892/ijo.22.6.1357
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Abstract

NADE, a p75NTR (low-affinity neurotrophin receptor p75) -associated cell death executor, was initially cloned from a human ovarian granulosa cell cDNA library, as an unknown protein with the name, pHGR74. It was reported to mediate nerve growth factor-induced apoptosis. We independently isolated human NADE (pHGR74) from breast cancer cell lines. Expression of NADE in various human cancer cell lines, and human and murine tissues was examined. NADE was highly expressed in human endocrine-related organs and embryotic murine tissues. Forced expression of NADE in CHO (Chinese hamster ovary) cells and MDA-MB-231 human breast cancer cells had little effect on the growth of the cells in vitro, while it dramatically suppressed cellular growth in vivo. We used the yeast two-hybrid system to search for NADE binding protein. Dynactin was identified as a candidate. The p75NTR was not found in this assay and did not co-immunoprecipitate with human NADE. Furthermore, the cells stably transfected with NADE did not respond to NGF or TNF. Thus, human and murine NADE appear to have different functions.

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Copy and paste a formatted citation
Spandidos Publications style
Tong X, Xie D, Roth W, Reed J and Koeffler HP: NADE (p75NTR-associated cell death executor) suppresses cellular growth in vivo. Int J Oncol 22: 1357-1362, 2003.
APA
Tong, X., Xie, D., Roth, W., Reed, J., & Koeffler, H.P. (2003). NADE (p75NTR-associated cell death executor) suppresses cellular growth in vivo. International Journal of Oncology, 22, 1357-1362. https://doi.org/10.3892/ijo.22.6.1357
MLA
Tong, X., Xie, D., Roth, W., Reed, J., Koeffler, H. P."NADE (p75NTR-associated cell death executor) suppresses cellular growth in vivo". International Journal of Oncology 22.6 (2003): 1357-1362.
Chicago
Tong, X., Xie, D., Roth, W., Reed, J., Koeffler, H. P."NADE (p75NTR-associated cell death executor) suppresses cellular growth in vivo". International Journal of Oncology 22, no. 6 (2003): 1357-1362. https://doi.org/10.3892/ijo.22.6.1357
Copy and paste a formatted citation
x
Spandidos Publications style
Tong X, Xie D, Roth W, Reed J and Koeffler HP: NADE (p75NTR-associated cell death executor) suppresses cellular growth in vivo. Int J Oncol 22: 1357-1362, 2003.
APA
Tong, X., Xie, D., Roth, W., Reed, J., & Koeffler, H.P. (2003). NADE (p75NTR-associated cell death executor) suppresses cellular growth in vivo. International Journal of Oncology, 22, 1357-1362. https://doi.org/10.3892/ijo.22.6.1357
MLA
Tong, X., Xie, D., Roth, W., Reed, J., Koeffler, H. P."NADE (p75NTR-associated cell death executor) suppresses cellular growth in vivo". International Journal of Oncology 22.6 (2003): 1357-1362.
Chicago
Tong, X., Xie, D., Roth, W., Reed, J., Koeffler, H. P."NADE (p75NTR-associated cell death executor) suppresses cellular growth in vivo". International Journal of Oncology 22, no. 6 (2003): 1357-1362. https://doi.org/10.3892/ijo.22.6.1357
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