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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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July 2003 Volume 23 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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July 2003 Volume 23 Issue 1

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Article

Ursolic acid induces apoptosis through caspase-3 activation and cell cycle arrest in HaCat cells

  • Authors:
    • Pierre-Olivier Harmand
    • Raphael Duval
    • Bertrand Liagre
    • Chantal Jayat-Vignoles
    • Jean-Louis Beneytout
    • Christiane Delage
    • Alain Simon

  • View Affiliations / Copyright

    Affiliations: Laboratoire de Chimie-Physique, UPRES EA 1085, Faculté de Pharmacie, 87025 Limoges Cedex, France
  • Pages: 105-112
    |
    Published online on: July 1, 2003
       https://doi.org/10.3892/ijo.23.1.105
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Abstract

Ursolic acid (UA) is a pentacyclic triterpene compound isolated from many kinds of medicinal plants and present in human diet. In this study, we investigated the pro-apoptotic effect of UA on HaCat derived keratinocyte cell line. Treatment with UA decreased the viability of HaCat cells in a concentration- and time-dependent manner. In addition, cell cycle analysis revealed that UA treated HaCat cells were blocked predominantly in G1 phase. Moreover, expression of p21WAF1, a cell cycle regulator, was increased by UA, indicating that UA-induced cell cycle arrest could be mediated through p21WAF1. During UA treatment, we also demonstrated that p53 was phosphorylated at serine 392 and translocated to the nucleus. It is well established that p53 achieves its tumor suppressor activity by inducing apoptosis on cells. To define the apoptotic process in our system, we examined effect of UA on caspase activities, and demonstrated caspase-3 activation. In conclusion, our results suggest that UA induces: i) cell cycle arrest concomitantly with the apparition of the apoptotic sub group G1 peak, and ii) cell death through apoptosis, which is mediated by caspase-3.

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Copy and paste a formatted citation
Spandidos Publications style
Harmand P, Duval R, Liagre B, Jayat-Vignoles C, Beneytout J, Delage C and Simon A: Ursolic acid induces apoptosis through caspase-3 activation and cell cycle arrest in HaCat cells. Int J Oncol 23: 105-112, 2003.
APA
Harmand, P., Duval, R., Liagre, B., Jayat-Vignoles, C., Beneytout, J., Delage, C., & Simon, A. (2003). Ursolic acid induces apoptosis through caspase-3 activation and cell cycle arrest in HaCat cells. International Journal of Oncology, 23, 105-112. https://doi.org/10.3892/ijo.23.1.105
MLA
Harmand, P., Duval, R., Liagre, B., Jayat-Vignoles, C., Beneytout, J., Delage, C., Simon, A."Ursolic acid induces apoptosis through caspase-3 activation and cell cycle arrest in HaCat cells". International Journal of Oncology 23.1 (2003): 105-112.
Chicago
Harmand, P., Duval, R., Liagre, B., Jayat-Vignoles, C., Beneytout, J., Delage, C., Simon, A."Ursolic acid induces apoptosis through caspase-3 activation and cell cycle arrest in HaCat cells". International Journal of Oncology 23, no. 1 (2003): 105-112. https://doi.org/10.3892/ijo.23.1.105
Copy and paste a formatted citation
x
Spandidos Publications style
Harmand P, Duval R, Liagre B, Jayat-Vignoles C, Beneytout J, Delage C and Simon A: Ursolic acid induces apoptosis through caspase-3 activation and cell cycle arrest in HaCat cells. Int J Oncol 23: 105-112, 2003.
APA
Harmand, P., Duval, R., Liagre, B., Jayat-Vignoles, C., Beneytout, J., Delage, C., & Simon, A. (2003). Ursolic acid induces apoptosis through caspase-3 activation and cell cycle arrest in HaCat cells. International Journal of Oncology, 23, 105-112. https://doi.org/10.3892/ijo.23.1.105
MLA
Harmand, P., Duval, R., Liagre, B., Jayat-Vignoles, C., Beneytout, J., Delage, C., Simon, A."Ursolic acid induces apoptosis through caspase-3 activation and cell cycle arrest in HaCat cells". International Journal of Oncology 23.1 (2003): 105-112.
Chicago
Harmand, P., Duval, R., Liagre, B., Jayat-Vignoles, C., Beneytout, J., Delage, C., Simon, A."Ursolic acid induces apoptosis through caspase-3 activation and cell cycle arrest in HaCat cells". International Journal of Oncology 23, no. 1 (2003): 105-112. https://doi.org/10.3892/ijo.23.1.105
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