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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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July 2003 Volume 23 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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July 2003 Volume 23 Issue 1

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Article

DNA variants of DLC-1, a candidate tumor suppressor gene in human hepatocellular carcinoma

  • Authors:
    • Sang-Won Park
    • Marian E. Durkin
    • Snorri S. Thorgeirsson
    • Nicholas C. Popescu

  • View Affiliations / Copyright

    Affiliations: Laboratory of Experimental Carcinogenesis, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA
  • Pages: 133-137
    |
    Published online on: July 1, 2003
       https://doi.org/10.3892/ijo.23.1.133
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Abstract

The DLC-1 gene encoding a regulator of the Rho family of small GTPases is altered in breast, prostate, colon, and liver cancer and has several characteristics of a tumor suppressor gene. DLC-1 overexpression causes inhibition of in vitro growth of liver tumor cells and complete suppression of in vivo tumorigenicity of breast tumor cells. Inactivation and aberrant expression of DLC-1 in human hepatocellular carcinoma (HCC) is frequently associated with hemizygous and homozygous genomic deletion and promoter methylation. Since inactivation of tumor suppressor genes in cancer cells is also commonly associated with point mutation, we evaluated the incidence of mutation of the DLC-1 gene by PCR-SSCP in 17 primary HCC and 18 HCC cell lines. One missense mutation was detected at codon 991 of exon 12 (C↷T transition, Val↷Ile) in an HCC cell line. In addition, two types of polymorphisms were identified: a G↷T at codon 745 of exon 9, a T↷C at 17 bp downstream of exon 2. While the pathogenic relevance of the intronic polymorphism is not known, the low rate of mutation of the DLC-1 gene in HCC implies that genomic deletion and promoter methylation primarily account for the altered expression and tumor suppressive inactivation of the DLC-1 gene.

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Copy and paste a formatted citation
Spandidos Publications style
Park S, Durkin ME, Thorgeirsson SS and Popescu NC: DNA variants of DLC-1, a candidate tumor suppressor gene in human hepatocellular carcinoma. Int J Oncol 23: 133-137, 2003.
APA
Park, S., Durkin, M.E., Thorgeirsson, S.S., & Popescu, N.C. (2003). DNA variants of DLC-1, a candidate tumor suppressor gene in human hepatocellular carcinoma. International Journal of Oncology, 23, 133-137. https://doi.org/10.3892/ijo.23.1.133
MLA
Park, S., Durkin, M. E., Thorgeirsson, S. S., Popescu, N. C."DNA variants of DLC-1, a candidate tumor suppressor gene in human hepatocellular carcinoma". International Journal of Oncology 23.1 (2003): 133-137.
Chicago
Park, S., Durkin, M. E., Thorgeirsson, S. S., Popescu, N. C."DNA variants of DLC-1, a candidate tumor suppressor gene in human hepatocellular carcinoma". International Journal of Oncology 23, no. 1 (2003): 133-137. https://doi.org/10.3892/ijo.23.1.133
Copy and paste a formatted citation
x
Spandidos Publications style
Park S, Durkin ME, Thorgeirsson SS and Popescu NC: DNA variants of DLC-1, a candidate tumor suppressor gene in human hepatocellular carcinoma. Int J Oncol 23: 133-137, 2003.
APA
Park, S., Durkin, M.E., Thorgeirsson, S.S., & Popescu, N.C. (2003). DNA variants of DLC-1, a candidate tumor suppressor gene in human hepatocellular carcinoma. International Journal of Oncology, 23, 133-137. https://doi.org/10.3892/ijo.23.1.133
MLA
Park, S., Durkin, M. E., Thorgeirsson, S. S., Popescu, N. C."DNA variants of DLC-1, a candidate tumor suppressor gene in human hepatocellular carcinoma". International Journal of Oncology 23.1 (2003): 133-137.
Chicago
Park, S., Durkin, M. E., Thorgeirsson, S. S., Popescu, N. C."DNA variants of DLC-1, a candidate tumor suppressor gene in human hepatocellular carcinoma". International Journal of Oncology 23, no. 1 (2003): 133-137. https://doi.org/10.3892/ijo.23.1.133
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