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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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July 2003 Volume 23 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Medicine International

An International Open Access Journal Devoted to General Medicine.

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July 2003 Volume 23 Issue 1

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Case Report

Highly complex karyotypic changes in acute myelogenous leukemia: a case report

  • Authors:
    • Anita Heller
    • Nikolai Rubtsov
    • Soili Kytölä
    • Tatyana V. Karamysheva
    • Olga V. Sablina
    • Marina M. Degtyareva
    • Heike Starke
    • Hermann Metzke
    • Uwe Claussen
    • Thomas Liehr

  • View Affiliations / Copyright

    Affiliations: Institute of Human Genetics and Anthropology, Jena, Germany
  • Pages: 139-143
    |
    Published online on: July 1, 2003
       https://doi.org/10.3892/ijo.23.1.139
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Abstract

We report on a patient with a clinically diagnosed acute myelogenous leukemia (AML) with so far unrecorded complex translocations. As GTG-banding was not able to resolve all karyotypic changes, spectral karyotyping (SKY) and multiplex-fluorescence in situ hybridization (M-FISH) were performed for comparison. Both methods gave nearly identical results, however, they were unable to characterize all involved chromosomal breakpoints in detail. Thus, multicolor banding (MCB) technique was applied and its results were confirmed for two large derivative chromosomes by microdissection and reverse painting. Using this battery of molecular cytogenetic approaches the karyotype of this AML case could be described as 40≈44,XY,der(1)t(1;5;8;20) (1qter↷1p12::5q14.3↷5q15 or 5q15↷5q14.3::8p11.2↷8p23.? 3::20p11.1↷20p13),del(2)(q12),der(3)t(3;6),der(5)t(5;18) (5p15.33↷5q11::18q21.3↷18q23),del(6),-8,der(9)t(9;17;15),der(10)t(3;10),del(11)(q24),-15,-16,del(17),der(18) t(8;18;5;2;20)(8q24.3↷8q24.2 or 8q24.2↷8q24.3::18p11.22↷18q21.3::5q14.3↷5q11::2q32↷2q12::20q13.2↷20q13.33), der(20)t(1;20;18)(1p36.33↷1p31.3-22.3::20p11.1↷20q11.2 or 20q11.2↷20p11.1::18p11.22↷18p11.32).

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Copy and paste a formatted citation
Spandidos Publications style
Heller A, Rubtsov N, Kytölä S, Karamysheva TV, Sablina OV, Degtyareva MM, Starke H, Metzke H, Claussen U, Liehr T, Liehr T, et al: Highly complex karyotypic changes in acute myelogenous leukemia: a case report. Int J Oncol 23: 139-143, 2003.
APA
Heller, A., Rubtsov, N., Kytölä, S., Karamysheva, T.V., Sablina, O.V., Degtyareva, M.M. ... Liehr, T. (2003). Highly complex karyotypic changes in acute myelogenous leukemia: a case report. International Journal of Oncology, 23, 139-143. https://doi.org/10.3892/ijo.23.1.139
MLA
Heller, A., Rubtsov, N., Kytölä, S., Karamysheva, T. V., Sablina, O. V., Degtyareva, M. M., Starke, H., Metzke, H., Claussen, U., Liehr, T."Highly complex karyotypic changes in acute myelogenous leukemia: a case report". International Journal of Oncology 23.1 (2003): 139-143.
Chicago
Heller, A., Rubtsov, N., Kytölä, S., Karamysheva, T. V., Sablina, O. V., Degtyareva, M. M., Starke, H., Metzke, H., Claussen, U., Liehr, T."Highly complex karyotypic changes in acute myelogenous leukemia: a case report". International Journal of Oncology 23, no. 1 (2003): 139-143. https://doi.org/10.3892/ijo.23.1.139
Copy and paste a formatted citation
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Spandidos Publications style
Heller A, Rubtsov N, Kytölä S, Karamysheva TV, Sablina OV, Degtyareva MM, Starke H, Metzke H, Claussen U, Liehr T, Liehr T, et al: Highly complex karyotypic changes in acute myelogenous leukemia: a case report. Int J Oncol 23: 139-143, 2003.
APA
Heller, A., Rubtsov, N., Kytölä, S., Karamysheva, T.V., Sablina, O.V., Degtyareva, M.M. ... Liehr, T. (2003). Highly complex karyotypic changes in acute myelogenous leukemia: a case report. International Journal of Oncology, 23, 139-143. https://doi.org/10.3892/ijo.23.1.139
MLA
Heller, A., Rubtsov, N., Kytölä, S., Karamysheva, T. V., Sablina, O. V., Degtyareva, M. M., Starke, H., Metzke, H., Claussen, U., Liehr, T."Highly complex karyotypic changes in acute myelogenous leukemia: a case report". International Journal of Oncology 23.1 (2003): 139-143.
Chicago
Heller, A., Rubtsov, N., Kytölä, S., Karamysheva, T. V., Sablina, O. V., Degtyareva, M. M., Starke, H., Metzke, H., Claussen, U., Liehr, T."Highly complex karyotypic changes in acute myelogenous leukemia: a case report". International Journal of Oncology 23, no. 1 (2003): 139-143. https://doi.org/10.3892/ijo.23.1.139
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