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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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July 2003 Volume 23 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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July 2003 Volume 23 Issue 1

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Article

Prophylactic, therapeutic and anti-metastatic effects of BMDC and DC lines in mice carrying HPV 16-associated tumours

  • Authors:
    • L. Mendoza
    • J. Bubeník
    • J. Símová
    • T. Jandlová
    • V. Vonka
    • R. Mikysková

  • View Affiliations / Copyright

    Affiliations: Institute of Molecular Genetics, Academy of Sciences of the Czech Republic, Prague, Czech Republic
  • Pages: 243-247
    |
    Published online on: July 1, 2003
       https://doi.org/10.3892/ijo.23.1.243
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Abstract

Oncogenic, moderately immunogenic MK16/1/IIIABC (MK16) cells were previously established by co-transfection of HPV 16 E6/E7 and activated H-ras oncogene DNA into C57BL/6 kidney cells. Subcutaneous transplantation of the MK16 cells produced progressively growing neoplasms which metastasized spontaneously to lungs. In this communication we report that prophylactic administration of bone marrow-derived dendritic cells (BMDC) as well as dendritic cell (DC) lines DC2.4 and JAWS II at the site of subsequent MK16 tumour transplants inhibited tumour growth and reduced the number of lung metastases. Similarly, in therapeutic experiments, administration of BMDC and DC lines at the site of the growing MK16 tumours or at the site of MK16 tumour residua after surgery inhibited tumour growth. Both BMDC-based vaccines and vaccines based on DC lines had also an antimetastatic effect. These results indicate that the DC line-based vaccines, which represent a standard, well-characterized and more homogeneous material, technically easier to prepare than the fresh BMDC-based vaccines, can be utilized for therapy of surgical minimal residual disease in HPV 16-associated neoplasms and are prospective for relevant clinical trials.

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Copy and paste a formatted citation
Spandidos Publications style
Mendoza L, Bubeník J, Símová J, Jandlová T, Vonka V and Mikysková R: Prophylactic, therapeutic and anti-metastatic effects of BMDC and DC lines in mice carrying HPV 16-associated tumours. Int J Oncol 23: 243-247, 2003.
APA
Mendoza, L., Bubeník, J., Símová, J., Jandlová, T., Vonka, V., & Mikysková, R. (2003). Prophylactic, therapeutic and anti-metastatic effects of BMDC and DC lines in mice carrying HPV 16-associated tumours. International Journal of Oncology, 23, 243-247. https://doi.org/10.3892/ijo.23.1.243
MLA
Mendoza, L., Bubeník, J., Símová, J., Jandlová, T., Vonka, V., Mikysková, R."Prophylactic, therapeutic and anti-metastatic effects of BMDC and DC lines in mice carrying HPV 16-associated tumours". International Journal of Oncology 23.1 (2003): 243-247.
Chicago
Mendoza, L., Bubeník, J., Símová, J., Jandlová, T., Vonka, V., Mikysková, R."Prophylactic, therapeutic and anti-metastatic effects of BMDC and DC lines in mice carrying HPV 16-associated tumours". International Journal of Oncology 23, no. 1 (2003): 243-247. https://doi.org/10.3892/ijo.23.1.243
Copy and paste a formatted citation
x
Spandidos Publications style
Mendoza L, Bubeník J, Símová J, Jandlová T, Vonka V and Mikysková R: Prophylactic, therapeutic and anti-metastatic effects of BMDC and DC lines in mice carrying HPV 16-associated tumours. Int J Oncol 23: 243-247, 2003.
APA
Mendoza, L., Bubeník, J., Símová, J., Jandlová, T., Vonka, V., & Mikysková, R. (2003). Prophylactic, therapeutic and anti-metastatic effects of BMDC and DC lines in mice carrying HPV 16-associated tumours. International Journal of Oncology, 23, 243-247. https://doi.org/10.3892/ijo.23.1.243
MLA
Mendoza, L., Bubeník, J., Símová, J., Jandlová, T., Vonka, V., Mikysková, R."Prophylactic, therapeutic and anti-metastatic effects of BMDC and DC lines in mice carrying HPV 16-associated tumours". International Journal of Oncology 23.1 (2003): 243-247.
Chicago
Mendoza, L., Bubeník, J., Símová, J., Jandlová, T., Vonka, V., Mikysková, R."Prophylactic, therapeutic and anti-metastatic effects of BMDC and DC lines in mice carrying HPV 16-associated tumours". International Journal of Oncology 23, no. 1 (2003): 243-247. https://doi.org/10.3892/ijo.23.1.243
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