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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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July 2003 Volume 23 Issue 1

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

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International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Article

Characterization of Hodgkin's lymphoma-like undifferentiated carcinoma of the nasopharyngeal type as a particular UCNT subtype mimicking Hodgkin's lymphoma

  • Authors:
    • Emmanuelle Charafe-Jauffret
    • François Bertucci
    • Olivier Ramuz
    • Elisabeth Devilard
    • Philippe Gaulard
    • Pierre Brousset
    • Remi Houlgatte
    • J. Hassoun
    • Daniel Birnbaum
    • Luc Xerri
  • View Affiliations / Copyright

    Affiliations: Department of Pathology, Institut Paoli-Calmettes, BP 156, Marseille cedex 9, F-13273, France. jauffrete@marseille.fnclcc.fr
  • Pages: 97-103
    |
    Published online on: July 1, 2003
       https://doi.org/10.3892/ijo.23.1.97
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Abstract

Undifferentiated carcinoma of the nasopharyngeal type (UCNT) that histologically mimics Hodgkin's lymphoma (HL) (‘Hodgkin's lymphoma-like UCNT’ - HL-like UCNT) is known as a diagnostic pitfall. Using immunohistochemistry, Western blot and cDNA array technology, we wanted to document its phenotypical and molecular characteristics. We report herein 5 cases of UCNT that morphologically mimic HL and 3 classical UCNT cases. We compared the expression profiles of a thousand selected genes in HL-like UCNT and in classical UCNT cases. No difference in the profile of EBV infection was noted between the HL-like UCNT and control cases. Significant differences were detected in the expression of genes involved in the matrix modelling, angiogenesis, apoptosis and regulation of the Th-2 interleukins. The eosinophil chemoattractant eotaxin was expressed in the stroma of HL-like UCNT, but not in the control cases. The eotaxin receptor CCR3 was expressed in both stromal and carcinoma cell populations of HL-like UCNT, this pattern being similar to the one observed in HL. These results show that UCNT morphologically resembling HL share also some specific phenotypical and molecular features with HL, and might deserve to be isolated as a particular UCNT subtype.

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Copy and paste a formatted citation
Spandidos Publications style
Charafe-Jauffret E, Bertucci F, Ramuz O, Devilard E, Gaulard P, Brousset P, Houlgatte R, Hassoun J, Birnbaum D, Xerri L, Xerri L, et al: Characterization of Hodgkin's lymphoma-like undifferentiated carcinoma of the nasopharyngeal type as a particular UCNT subtype mimicking Hodgkin's lymphoma. Int J Oncol 23: 97-103, 2003.
APA
Charafe-Jauffret, E., Bertucci, F., Ramuz, O., Devilard, E., Gaulard, P., Brousset, P. ... Xerri, L. (2003). Characterization of Hodgkin's lymphoma-like undifferentiated carcinoma of the nasopharyngeal type as a particular UCNT subtype mimicking Hodgkin's lymphoma. International Journal of Oncology, 23, 97-103. https://doi.org/10.3892/ijo.23.1.97
MLA
Charafe-Jauffret, E., Bertucci, F., Ramuz, O., Devilard, E., Gaulard, P., Brousset, P., Houlgatte, R., Hassoun, J., Birnbaum, D., Xerri, L."Characterization of Hodgkin's lymphoma-like undifferentiated carcinoma of the nasopharyngeal type as a particular UCNT subtype mimicking Hodgkin's lymphoma". International Journal of Oncology 23.1 (2003): 97-103.
Chicago
Charafe-Jauffret, E., Bertucci, F., Ramuz, O., Devilard, E., Gaulard, P., Brousset, P., Houlgatte, R., Hassoun, J., Birnbaum, D., Xerri, L."Characterization of Hodgkin's lymphoma-like undifferentiated carcinoma of the nasopharyngeal type as a particular UCNT subtype mimicking Hodgkin's lymphoma". International Journal of Oncology 23, no. 1 (2003): 97-103. https://doi.org/10.3892/ijo.23.1.97
Copy and paste a formatted citation
x
Spandidos Publications style
Charafe-Jauffret E, Bertucci F, Ramuz O, Devilard E, Gaulard P, Brousset P, Houlgatte R, Hassoun J, Birnbaum D, Xerri L, Xerri L, et al: Characterization of Hodgkin's lymphoma-like undifferentiated carcinoma of the nasopharyngeal type as a particular UCNT subtype mimicking Hodgkin's lymphoma. Int J Oncol 23: 97-103, 2003.
APA
Charafe-Jauffret, E., Bertucci, F., Ramuz, O., Devilard, E., Gaulard, P., Brousset, P. ... Xerri, L. (2003). Characterization of Hodgkin's lymphoma-like undifferentiated carcinoma of the nasopharyngeal type as a particular UCNT subtype mimicking Hodgkin's lymphoma. International Journal of Oncology, 23, 97-103. https://doi.org/10.3892/ijo.23.1.97
MLA
Charafe-Jauffret, E., Bertucci, F., Ramuz, O., Devilard, E., Gaulard, P., Brousset, P., Houlgatte, R., Hassoun, J., Birnbaum, D., Xerri, L."Characterization of Hodgkin's lymphoma-like undifferentiated carcinoma of the nasopharyngeal type as a particular UCNT subtype mimicking Hodgkin's lymphoma". International Journal of Oncology 23.1 (2003): 97-103.
Chicago
Charafe-Jauffret, E., Bertucci, F., Ramuz, O., Devilard, E., Gaulard, P., Brousset, P., Houlgatte, R., Hassoun, J., Birnbaum, D., Xerri, L."Characterization of Hodgkin's lymphoma-like undifferentiated carcinoma of the nasopharyngeal type as a particular UCNT subtype mimicking Hodgkin's lymphoma". International Journal of Oncology 23, no. 1 (2003): 97-103. https://doi.org/10.3892/ijo.23.1.97
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