Chemoembolization with cisplatin, lipiodol and gelfoam® and subsequent systemic chemotherapy with cisplatin and interferon in patients with hepatocellular carcinoma: a non-randomized prospective study

  • Authors:
    • Martina Baur
    • Reinhard Walter
    • Axel Gebauer
    • Dimiter Tscholakoff
    • Herbert Lochs
    • Ferdinand Mühlbacher
    • Karl Turetschek
    • Reinhard Binder
    • Marcus Hudec
    • Alfred Gangl
    • Peter Ferenci
    • Christian Dittrich
  • View Affiliations

  • Published online on: September 1, 2003     https://doi.org/10.3892/ijo.23.3.811
  • Pages: 811-819
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Abstract

Arterial chemoembolization with subsequent systemic chemotherapy was assessed prospectively. Of 94 consecutive patients with HCC, 31 patients were considered to have inoperable disease and were selected for chemoembolization. Twenty-two of the 31 patients underwent chemoembolization. In eight patients, technical problems with catheterization prevented the application of therapy, and one patient rejected further treatment. Regimen: Three monthly cycles of chemoembolization with cisplatin 20 mg/m2 mixed with lipiodol delivered intraarterially with gelfoam or collagen on day 1, followed by intravenous chemotherapy with cisplatin 60 mg/m2 on day 2; interferon α-2c 30 µg (10 M IU) subcutaneously on days 2, 5, 9, and 12. Three percent of the patients (1/31) (CI 95% 0.08; 16.7) experienced a partial clinical response, in 53% α-fetoprotein levels decreased by more than 50%. On univariate analysis, performance status, Child score, Okuda stage, albumin levels, and lactate dehydrogenase were found to have an effect on survival. Postchemoembolization syndrome occurred in 68% of the patients, nausea/vomiting grades 3/4 (according to the World Health Organization WHO) in six patients, anemia grade 3 in three patients, leukopenia grade 3 in one patient and thrombocytopenia grade 3 in one patient. This treatment regimen is a very selective procedure. Because of the low response rate it is not recommended for routine clinical use.

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September 2003
Volume 23 Issue 3

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Baur M, Walter R, Gebauer A, Tscholakoff D, Lochs H, Mühlbacher F, Turetschek K, Binder R, Hudec M, Gangl A, Gangl A, et al: Chemoembolization with cisplatin, lipiodol and gelfoam® and subsequent systemic chemotherapy with cisplatin and interferon in patients with hepatocellular carcinoma: a non-randomized prospective study. Int J Oncol 23: 811-819, 2003
APA
Baur, M., Walter, R., Gebauer, A., Tscholakoff, D., Lochs, H., Mühlbacher, F. ... Dittrich, C. (2003). Chemoembolization with cisplatin, lipiodol and gelfoam® and subsequent systemic chemotherapy with cisplatin and interferon in patients with hepatocellular carcinoma: a non-randomized prospective study. International Journal of Oncology, 23, 811-819. https://doi.org/10.3892/ijo.23.3.811
MLA
Baur, M., Walter, R., Gebauer, A., Tscholakoff, D., Lochs, H., Mühlbacher, F., Turetschek, K., Binder, R., Hudec, M., Gangl, A., Ferenci, P., Dittrich, C."Chemoembolization with cisplatin, lipiodol and gelfoam® and subsequent systemic chemotherapy with cisplatin and interferon in patients with hepatocellular carcinoma: a non-randomized prospective study". International Journal of Oncology 23.3 (2003): 811-819.
Chicago
Baur, M., Walter, R., Gebauer, A., Tscholakoff, D., Lochs, H., Mühlbacher, F., Turetschek, K., Binder, R., Hudec, M., Gangl, A., Ferenci, P., Dittrich, C."Chemoembolization with cisplatin, lipiodol and gelfoam® and subsequent systemic chemotherapy with cisplatin and interferon in patients with hepatocellular carcinoma: a non-randomized prospective study". International Journal of Oncology 23, no. 3 (2003): 811-819. https://doi.org/10.3892/ijo.23.3.811