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International Journal of Oncology
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Print ISSN: 1019-6439 Online ISSN: 1791-2423
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October 2003 Volume 23 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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October 2003 Volume 23 Issue 4

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Article

Acquisition of drug resistance by constitutive suppression of NF-κB in ras-transformed NIH3T3 mouse fibroblasts

  • Authors:
    • Tsukasa Sakaida
    • Yasuo Iwadate
    • Sachi Yamaji
    • Masae Uehara
    • Asao Noda
    • Masaki Takiguchi
    • Akira Yamaura
    • Takaki Hiwasa

  • View Affiliations / Copyright

    Affiliations: Department of Biochemistry and Genetics, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan
  • Pages: 1071-1077
    |
    Published online on: October 1, 2003
       https://doi.org/10.3892/ijo.23.4.1071
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Abstract

Apoptotic cell death is frequently suppressed by NF-κB transcription factor. We examined the effects of NF-κB on the sensitivity to anti-cancer drugs by using two NF-κB-inhibitory molecules, IκBα-super-repressor (IκBα-SR) and dominant negative IKKβ (IKKβ-DN). Ha-ras-transformed NIH3T3 (ras-NIH3T3) mouse fibroblasts were stably transfected with these cDNAs, and suppression of NF-κB activity was confirmed by electrophoretic mobility shift assays. Cell viability analysis revealed that IκBα-SR- or IKKβ-DN-transfected cells were more resistant to peplomycin, mitomycin C, and camptothecin. Flow cytometric analysis indicated partial G1 arrest of these transfected cells. Consistently, elevated expression of IκBα-SR and IKKβ-DN was accompanied by increased levels of p21 but not of Bax. Transfection of p21 into ras-NIH3T3 cells caused similar reduced chemosensitivity to the anti-cancer drugs. These results collectively indicate that constitutive suppression of NF-κB activity reduced the chemosensitivity to anti-cancer drugs via enhanced expression of p21.

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Copy and paste a formatted citation
Spandidos Publications style
Sakaida T, Iwadate Y, Yamaji S, Uehara M, Noda A, Takiguchi M, Yamaura A and Hiwasa T: Acquisition of drug resistance by constitutive suppression of NF-κB in ras-transformed NIH3T3 mouse fibroblasts. Int J Oncol 23: 1071-1077, 2003.
APA
Sakaida, T., Iwadate, Y., Yamaji, S., Uehara, M., Noda, A., Takiguchi, M. ... Hiwasa, T. (2003). Acquisition of drug resistance by constitutive suppression of NF-κB in ras-transformed NIH3T3 mouse fibroblasts. International Journal of Oncology, 23, 1071-1077. https://doi.org/10.3892/ijo.23.4.1071
MLA
Sakaida, T., Iwadate, Y., Yamaji, S., Uehara, M., Noda, A., Takiguchi, M., Yamaura, A., Hiwasa, T."Acquisition of drug resistance by constitutive suppression of NF-κB in ras-transformed NIH3T3 mouse fibroblasts". International Journal of Oncology 23.4 (2003): 1071-1077.
Chicago
Sakaida, T., Iwadate, Y., Yamaji, S., Uehara, M., Noda, A., Takiguchi, M., Yamaura, A., Hiwasa, T."Acquisition of drug resistance by constitutive suppression of NF-κB in ras-transformed NIH3T3 mouse fibroblasts". International Journal of Oncology 23, no. 4 (2003): 1071-1077. https://doi.org/10.3892/ijo.23.4.1071
Copy and paste a formatted citation
x
Spandidos Publications style
Sakaida T, Iwadate Y, Yamaji S, Uehara M, Noda A, Takiguchi M, Yamaura A and Hiwasa T: Acquisition of drug resistance by constitutive suppression of NF-κB in ras-transformed NIH3T3 mouse fibroblasts. Int J Oncol 23: 1071-1077, 2003.
APA
Sakaida, T., Iwadate, Y., Yamaji, S., Uehara, M., Noda, A., Takiguchi, M. ... Hiwasa, T. (2003). Acquisition of drug resistance by constitutive suppression of NF-κB in ras-transformed NIH3T3 mouse fibroblasts. International Journal of Oncology, 23, 1071-1077. https://doi.org/10.3892/ijo.23.4.1071
MLA
Sakaida, T., Iwadate, Y., Yamaji, S., Uehara, M., Noda, A., Takiguchi, M., Yamaura, A., Hiwasa, T."Acquisition of drug resistance by constitutive suppression of NF-κB in ras-transformed NIH3T3 mouse fibroblasts". International Journal of Oncology 23.4 (2003): 1071-1077.
Chicago
Sakaida, T., Iwadate, Y., Yamaji, S., Uehara, M., Noda, A., Takiguchi, M., Yamaura, A., Hiwasa, T."Acquisition of drug resistance by constitutive suppression of NF-κB in ras-transformed NIH3T3 mouse fibroblasts". International Journal of Oncology 23, no. 4 (2003): 1071-1077. https://doi.org/10.3892/ijo.23.4.1071
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